Startseite Impact of Obesity on Bone Metabolism in Children
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Impact of Obesity on Bone Metabolism in Children

  • Hüseyin Anıl Korkmaz ORCID logo EMAIL logo und Behzat Özkan
Veröffentlicht/Copyright: 11. April 2022
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 35 Heft 5

Abstract

Obesity is an epidemic disease that can increase the incidence of type 2 diabetes, cardiovascular disease, malignancy, hypertension, and other health problems that affect the musculoskeletal system. There is a complex interaction between obesity and bone metabolism. In children with obesity, the peroxisome proliferator-activated receptor gamma pathway causes the differentiation of mesenchymal stem cells into adipocytes via osteoblasts, in which results in low bone mass and osteoporosis. Systemic inflammation in obesity has negative effects on bone metabolism. An increase in the number and size of adipose tissue and adipocytokines secreted from adipocytes affect the bone mass of the whole body with hormonal and biochemical effects. The skeletal effects of obesity are mediated by higher oxidative stress and increased production of proinflammatory cytokines. Osteoporosis due to obesity has increased morbidity and mortality in recent years, resulting in important health problems in developed and developing countries.

Keywords: adipose tissue; bone metabolism; obesity; osteoporosis
Corresponding author: Hüseyin Anıl Korkmaz, Department of Pediatrics, Division of Pediatric Endocrinology, Dr Behcet Uz Child Disease and Surgery Training and Research Hospital, Behcet Uz Children Hospital, Izmir, Turkey, Phone: +90 (0232) 411 60 00, E-mail:

  1. Research funding: None declared.

  2. Author contribution: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.

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Received: 2021-11-26
Revised: 2022-02-04
Accepted: 2022-02-28
Published Online: 2022-04-11
Published in Print: 2022-05-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. Impact of Obesity on Bone Metabolism in Children
  4. Mini Review
  5. Late sequelae of drug reaction with eosinophilia and systemic symptoms (DRESS) cause thyroid dysfunction and thyroiditis: review of literature
  6. Original Articles
  7. Moderating effect of bone maturation on the relationship between body fat and insulin resistance
  8. Prevalence of nephropathy in Indian children and youth with type 1 diabetes mellitus
  9. Initial neutrophil/lymphocyte and lymphocyte/monocyte ratios can predict future insulin need in newly diagnosed type 1 diabetes mellitus
  10. Subcutaneous adipose tissue is a positive predictor for bone mineral density in prepubertal children with Prader–Willi syndrome independent of lean mass
  11. The attitudes, experiences, and self-competencies of pediatric endocrinology fellows and attending physicians regarding diabetes technology: the Turkey experience
  12. Adiposity measures in screening for metabolic syndrome among Chinese children and adolescents
  13. Increased anxiety symptoms in pediatric type 1 diabetes during the acute phase of COVID-19 lockdown
  14. Pediatric adrenal insufficiency: thirty years experience at a Portuguese hospital
  15. Spectrum of PAH gene mutations and genotype–phenotype correlation in patients with phenylalanine hydroxylase deficiency from Turkey
  16. Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term
  17. Familial early-onset obesity in Turkish children: variants and polymorphisms in the melanocortin-4 receptor (MC4R) gene
  18. An update of the mutation spectrum of phenylalanine hydroxylase (PAH) gene in the population of Turkey
  19. Primary hypertriglyceridemia induced pancreatitis in a cohort of Pakistani children
  20. Investigation of the relationship between serum sclerostin and dickkopf-1 protein levels with bone turnover in children and adolescents with type-1 diabetes mellitus
  21. Case Reports
  22. Diagnostic value of plasma lysosphingolipids levels in a Niemann–Pick disease type C patient with transient neonatal cholestasis
  23. A 7-year-old boy with central diabetes insipidus presenting with thickened pituitary stalk and anti-rabphilin-3A antibody positivity
  24. Homozygous missense variant of PTH (c.166C>T, p.(Arg56Cys)) as the cause of familial isolated hypoparathyroidism in a three-year-old child
  25. Long-term follow-up of transient neonatal diabetes mellitus due to a novel homozygous c.7734C>T (p.R228C) mutation in ZFP57 gene: relapse at prepubertal age
https://doi.org/10.1515/jpem-2021-0714
Schlagwörter für diesen Artikel
adipose tissue; bone metabolism; obesity; osteoporosis

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. Impact of Obesity on Bone Metabolism in Children
  4. Mini Review
  5. Late sequelae of drug reaction with eosinophilia and systemic symptoms (DRESS) cause thyroid dysfunction and thyroiditis: review of literature
  6. Original Articles
  7. Moderating effect of bone maturation on the relationship between body fat and insulin resistance
  8. Prevalence of nephropathy in Indian children and youth with type 1 diabetes mellitus
  9. Initial neutrophil/lymphocyte and lymphocyte/monocyte ratios can predict future insulin need in newly diagnosed type 1 diabetes mellitus
  10. Subcutaneous adipose tissue is a positive predictor for bone mineral density in prepubertal children with Prader–Willi syndrome independent of lean mass
  11. The attitudes, experiences, and self-competencies of pediatric endocrinology fellows and attending physicians regarding diabetes technology: the Turkey experience
  12. Adiposity measures in screening for metabolic syndrome among Chinese children and adolescents
  13. Increased anxiety symptoms in pediatric type 1 diabetes during the acute phase of COVID-19 lockdown
  14. Pediatric adrenal insufficiency: thirty years experience at a Portuguese hospital
  15. Spectrum of PAH gene mutations and genotype–phenotype correlation in patients with phenylalanine hydroxylase deficiency from Turkey
  16. Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term
  17. Familial early-onset obesity in Turkish children: variants and polymorphisms in the melanocortin-4 receptor (MC4R) gene
  18. An update of the mutation spectrum of phenylalanine hydroxylase (PAH) gene in the population of Turkey
  19. Primary hypertriglyceridemia induced pancreatitis in a cohort of Pakistani children
  20. Investigation of the relationship between serum sclerostin and dickkopf-1 protein levels with bone turnover in children and adolescents with type-1 diabetes mellitus
  21. Case Reports
  22. Diagnostic value of plasma lysosphingolipids levels in a Niemann–Pick disease type C patient with transient neonatal cholestasis
  23. A 7-year-old boy with central diabetes insipidus presenting with thickened pituitary stalk and anti-rabphilin-3A antibody positivity
  24. Homozygous missense variant of PTH (c.166C>T, p.(Arg56Cys)) as the cause of familial isolated hypoparathyroidism in a three-year-old child
  25. Long-term follow-up of transient neonatal diabetes mellitus due to a novel homozygous c.7734C>T (p.R228C) mutation in ZFP57 gene: relapse at prepubertal age
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