Startseite Long-term follow-up of differentiated thyroid carcinoma in children and adolescents
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Long-term follow-up of differentiated thyroid carcinoma in children and adolescents

  • Montserrat Negre Busó EMAIL logo , Amparo García Burillo , Marc Simó Perdigó , Pere Galofré Mora , Maria Boronat de Ferrater , Gemma Cuberas Borrós , Constantino Sábado Álvarez und Joan Castell Conesa
Veröffentlicht/Copyright: 2. September 2020
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 33 Heft 11

Abstract

Objectives

The aims were to analyze the clinical features, response to treatment, prognostic factors and long-term follow-up of children and adolescents with differentiated thyroid carcinoma (DTC).

Methods

Eighty patients with DTC were studied retrospectively. All underwent total or near-total thyroidectomy, and in 75 cases, ablative iodine therapy was recommended. Patients were assessed periodically by tests for serum thyroglobulin levels and whole-body iodine scans. Age, gender, initial clinical presentation, histology, tumor stage, postoperative complications, radioiodine treatment protocol, treatment response, thyroglobulin (Tg), recurrence and long-term disease progression were evaluated.

Results

Seventy patients completed >2 years of follow-up (23 males, 47 females; median age: 14 years; range: 3–18 years). Sixty-two patients showed papillary DTC and eight, follicular DTC. Sixty-five percent presented nodal metastasis and 16%, pulmonary metastasis at diagnosis. Six months after first radioiodine treatment, 36.2% of patients were free of disease. Seven recurrences were documented. At the end of follow-up, overall survival was 100%, and 87.2% of patients were in complete remission. Nine patients had persistent disease. We found a significant association between stage 4 and persistent disease. Hundred percent of patients with negative Tg values at 6 months posttreatment were documented free of disease at the end of the follow-up. The analysis of disease-free survival based on radioiodine treatment protocols used showed no statistically significant differences.

Conclusions

DTC in children and adolescents is frequently associated with presence of advanced disease at diagnosis. Despite this, complete remission was documented after treatment in most cases, with a good prognosis in the long-term follow-up. Negative posttreatment thyroglobulin and stage 4 at diagnosis were significant prognostic variables.

Keywords: children; prognostic factors; stages; thyroid carcinoma; thyroglobulin
Corresponding author: Montserrat Negre Busó, Nuclear Medicine Service-IDI, Hospital Universitari de Girona Dr. Josep Trueta, Avda França s/n. 17007, Girona, Catalonia, Spain. Phone: 972225786, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report or in the decision to submit the report for publication.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: All procedures in the present study were performed in accordance with the ethical guidelines for research involving human participants, as stated in the 1975 Declaration of Helsinki and its later amendments.

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Received: 2020-04-15
Accepted: 2020-07-31
Published Online: 2020-09-02
Published in Print: 2020-11-26

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. The influence of growth hormone therapy on the cardiovascular system in Turner syndrome
  4. Original Articles
  5. Clinical utility of urinary gonadotrophins in hypergonadotrophic states as Turner syndrome
  6. Sclerostin and osteoprotegerin: new markers of chronic kidney disease mediated mineral and bone disease in children
  7. Monthly intravenous alendronate treatment can maintain bone strength in osteogenesis imperfecta patients following cyclical pamidronate treatment
  8. Mechanisms and early patterns of dyslipidemia in pediatric type 1 and type 2 diabetes
  9. Frequency of thyroid dysfunction in pediatric patients with congenital heart disease exposed to iodinated contrast media – a long-term observational study
  10. Effect of growth hormone therapy on thyroid function in isolated growth hormone deficient and short small for gestational age children: a two-year study, including on assessment of the usefulness of the thyrotropin-releasing hormone (TRH) stimulation test
  11. Clinical relevance of T lymphocyte subsets in pediatric Graves’ disease
  12. Long-term follow-up of differentiated thyroid carcinoma in children and adolescents
  13. A quality improvement project for managing hypocalcemia after pediatric total thyroidectomy
  14. Pubertal development and adult height in patients with congenital hypothyroidism detected by neonatal screening in southern Brazil
  15. Clinical characteristics, surgical approach, BRAFV600E mutation and sodium iodine symporter expression in pediatric patients with thyroid carcinoma
  16. BRAFV600E and TERT promoter mutations in paediatric and young adult papillary thyroid cancer and clinicopathological correlation
  17. Case Reports
  18. Pseudohypoparathyroidism type 1B (PHP1B), a rare disorder encountered in adolescence
  19. Impaired glucose homeostasis and a novel HLCS pathogenic variant in holocarboxylase synthetase deficiency: a report of two cases and brief review
  20. Transcobalamin II deficiency in twins with a novel variant in the TCN2 gene: case report and review of literature
  21. Aldosterone deficiency with a hormone profile mimicking pseudohypoaldosteronism
  22. Non-classical lipoid adrenal hyperplasia presenting as hypoglycemic seizures
https://doi.org/10.1515/jpem-2020-0194
Schlagwörter für diesen Artikel
children; prognostic factors; stages; thyroid carcinoma; thyroglobulin

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. The influence of growth hormone therapy on the cardiovascular system in Turner syndrome
  4. Original Articles
  5. Clinical utility of urinary gonadotrophins in hypergonadotrophic states as Turner syndrome
  6. Sclerostin and osteoprotegerin: new markers of chronic kidney disease mediated mineral and bone disease in children
  7. Monthly intravenous alendronate treatment can maintain bone strength in osteogenesis imperfecta patients following cyclical pamidronate treatment
  8. Mechanisms and early patterns of dyslipidemia in pediatric type 1 and type 2 diabetes
  9. Frequency of thyroid dysfunction in pediatric patients with congenital heart disease exposed to iodinated contrast media – a long-term observational study
  10. Effect of growth hormone therapy on thyroid function in isolated growth hormone deficient and short small for gestational age children: a two-year study, including on assessment of the usefulness of the thyrotropin-releasing hormone (TRH) stimulation test
  11. Clinical relevance of T lymphocyte subsets in pediatric Graves’ disease
  12. Long-term follow-up of differentiated thyroid carcinoma in children and adolescents
  13. A quality improvement project for managing hypocalcemia after pediatric total thyroidectomy
  14. Pubertal development and adult height in patients with congenital hypothyroidism detected by neonatal screening in southern Brazil
  15. Clinical characteristics, surgical approach, BRAFV600E mutation and sodium iodine symporter expression in pediatric patients with thyroid carcinoma
  16. BRAFV600E and TERT promoter mutations in paediatric and young adult papillary thyroid cancer and clinicopathological correlation
  17. Case Reports
  18. Pseudohypoparathyroidism type 1B (PHP1B), a rare disorder encountered in adolescence
  19. Impaired glucose homeostasis and a novel HLCS pathogenic variant in holocarboxylase synthetase deficiency: a report of two cases and brief review
  20. Transcobalamin II deficiency in twins with a novel variant in the TCN2 gene: case report and review of literature
  21. Aldosterone deficiency with a hormone profile mimicking pseudohypoaldosteronism
  22. Non-classical lipoid adrenal hyperplasia presenting as hypoglycemic seizures
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