Startseite Medizin Mechanisms and early patterns of dyslipidemia in pediatric type 1 and type 2 diabetes
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Mechanisms and early patterns of dyslipidemia in pediatric type 1 and type 2 diabetes

  • Benjamin Udoka Nwosu EMAIL logo , Tony R. Villalobos-Ortiz , Gabrielle A. Jasmin , Sadichchha Parajuli , Emily Zitek-Morrison und Bruce A. Barton
Veröffentlicht/Copyright: 7. Oktober 2020
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 33 Heft 11

Abstract

Objectives

The is no consensus on the early patterns of lipid-based cardiovascular disease (CVD) risk in youth with either type 1 diabetes (T1D) or type 2 diabetes (T2D). The aim was todetermine the differences in CVD risk, using lipid profiles, in children and adolescents with either T1D or T2D at the time of their first lipid assessment, after stratifying the T1D cohort into remitters and non-remitters based on their honeymoon history.

Methods

A cross-sectional study of 249 subjects consisting of 73 controls, 53 T2D subjects, and 123 T1D subjects stratified into remitters (n=44), and non-remitters (n=79). Partial clinical remission (PCR) was defined as insulin-dose adjusted HbA1c of ≤9. Pubertal status was determined by Tanner staging.

Results

After adjusting for age, sex, BMI, race, and pubertal status, T2D patients had significantly higher LDL-C compared to the controls (p=0.022), the remitters (p=0.029), but not the non-remitters (103.1 ± 5.9 mg/dL vs. 91.4 ± 4.2 mg/dL, p=0.49). Similarly, T2D patients had significantly higher non-HDL-C compared to the controls (p=0.006), the remitters (p=0.0002), but not the non-remitters (137.6 ± 7.1 mg/dL vs. 111.71 ± 5.0 mg/dL, p=0.053). Total cholesterol was also significantly higher in T2D patients compared to the controls (p=0.0005), the remitters (p=0.006) but not the non-remitters (183.5 ± 6.6 mg/dL vs. 166.2 ± 4.8 mg/dL, p=0.27).

Conclusions

Lack of the honeymoon phase in children and adolescents with T1D confers early and significantly increased lipid-based cardiovascular risk to these patients that is similar to the elevated cardiovascular risk seen in T2D.

Keywords: cardiovascular disease risk; children; dyslipidemia; honeymoon phase; type 1 diabetes; type 2 diabetes
Corresponding author: Benjamin Udoka Nwosu, MD, Department of Pediatrics, Division of Endocrinology, University of Massachusetts Medical School, Worcester, MA, USA, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: No funding organizations played a role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Ethical approval: The study protocol and the waiver of authorization to review subjects’ retrospective records were approved by the Institutional Review Board of the University of Massachusetts, Docket #H00015476. All subjects’ data were anonymized and de-identified prior to analysis.

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Received: 2020-04-26
Accepted: 2020-08-17
Published Online: 2020-10-07
Published in Print: 2020-11-26

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jpem-2020-0220
Schlagwörter für diesen Artikel
cardiovascular disease risk; children; dyslipidemia; honeymoon phase; type 1 diabetes; type 2 diabetes

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. The influence of growth hormone therapy on the cardiovascular system in Turner syndrome
  4. Original Articles
  5. Clinical utility of urinary gonadotrophins in hypergonadotrophic states as Turner syndrome
  6. Sclerostin and osteoprotegerin: new markers of chronic kidney disease mediated mineral and bone disease in children
  7. Monthly intravenous alendronate treatment can maintain bone strength in osteogenesis imperfecta patients following cyclical pamidronate treatment
  8. Mechanisms and early patterns of dyslipidemia in pediatric type 1 and type 2 diabetes
  9. Frequency of thyroid dysfunction in pediatric patients with congenital heart disease exposed to iodinated contrast media – a long-term observational study
  10. Effect of growth hormone therapy on thyroid function in isolated growth hormone deficient and short small for gestational age children: a two-year study, including on assessment of the usefulness of the thyrotropin-releasing hormone (TRH) stimulation test
  11. Clinical relevance of T lymphocyte subsets in pediatric Graves’ disease
  12. Long-term follow-up of differentiated thyroid carcinoma in children and adolescents
  13. A quality improvement project for managing hypocalcemia after pediatric total thyroidectomy
  14. Pubertal development and adult height in patients with congenital hypothyroidism detected by neonatal screening in southern Brazil
  15. Clinical characteristics, surgical approach, BRAFV600E mutation and sodium iodine symporter expression in pediatric patients with thyroid carcinoma
  16. BRAFV600E and TERT promoter mutations in paediatric and young adult papillary thyroid cancer and clinicopathological correlation
  17. Case Reports
  18. Pseudohypoparathyroidism type 1B (PHP1B), a rare disorder encountered in adolescence
  19. Impaired glucose homeostasis and a novel HLCS pathogenic variant in holocarboxylase synthetase deficiency: a report of two cases and brief review
  20. Transcobalamin II deficiency in twins with a novel variant in the TCN2 gene: case report and review of literature
  21. Aldosterone deficiency with a hormone profile mimicking pseudohypoaldosteronism
  22. Non-classical lipoid adrenal hyperplasia presenting as hypoglycemic seizures
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Heruntergeladen am 31.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jpem-2020-0220/html
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