Startseite Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity
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Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity

  • Xin Yuan , Ruimin Chen ORCID logo EMAIL logo , Qian Ouyang , Xiangquan Lin , Zhuanzhuan Ai , Ying Zhang und Xiaohong Yang
Veröffentlicht/Copyright: 18. Januar 2020

Abstract

Background

The relationship between cytokines and lipid metabolism has garnered attention given their potential metabolic interaction. However, the relationship between adropin and lipopolysaccharide-binding protein (LBP) and obesity-related inflammation has not been reported, as well as their relationship with serum lipid profiles.

Objective

This study analyzed the association of serum adropin, leptin, LBP levels and lipid profiles in obese children ranging from 5 to 14 years old.

Methods

Plasma lipid measurements included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) by standard methods, and serum adropin, leptin and LBP levels was measured by enzyme-linked immunosorbent assay (ELISA).

Results

One hundred and twenty-four children (9.25 ± 1.59 years) with obesity and 42 controls (8.81 ± 1.94 years) were assessed. Compared with the control group, the serum adropin concentrations in the obesity group were significantly lower, whereas the serum leptin and LBP levels were significantly higher. Pearson’s correlation analysis showed that serum adropin levels negatively correlated with TG, waist to hip ratio (WHR) and body mass index (BMI), and positively correlated with HDL-c. Serum LBP levels positively correlated with LDL-c and WHR. After adjusting for LBP, the correlation coefficients of adropin with TG, HDL-c and leptin were more robust. Also, after adjusting for serum LBP, the correlation coefficient of leptin with TG was attenuated, yet remained statistically significant, and the correlation coefficient of leptin with HDL-c was enhanced.

Conclusions

Children with obesity have decreased serum adropin levels and elevated leptin and LBP levels. Each of the three serum cytokines were associated with lipid metabolism, and this association warrants further study.

  1. Conflict of interest: The authors declare that they have no conflict of interest.

  2. Funding: This study was supported by the National Key Research and Development Program of China (2016YFC1305301), Technology Innovation Team Train Project of Fuzhou Health Committee in China (2016-S-wp1), and sponsored by key Clinical Specialty Discipline Construction Program of Fuzhou, Fujian, P.R.C. (201610191).

  3. Ethical approval: This study was reviewed and approved by the Ethics Committee of Fuzhou Children’s Hospital of Fujian, and was conducted in agreement with the Declaration of Helsinki Principles.

  4. Informed consent: Informed consent was obtained from all individual participants included in the study.

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Received: 2019-07-16
Accepted: 2019-11-15
Published Online: 2020-01-18
Published in Print: 2020-02-25

©2020 Walter de Gruyter GmbH, Berlin/Boston

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