Air occlusion in insulin pumps of children and adolescents with type 1 diabetes
-
Michelle M. Knoll
,
Turaj Vazifedan
Abstract
Background
Insulin pumps are a frequently used technology among youth with type 1 diabetes. Air bubbles within insulin pump tubing are common, preventing insulin delivery and increasing the risk of large glycemic excursions and diabetic ketoacidosis (DKA). We sought to determine the prevalence of air bubbles in insulin pump tubing and identify factors associated with clinically significant air bubbles.
Methods
Fifty-three subjects were recruited over 65 office visits. The insulin pump tubing was visualized, and any air bubbles were measured by length. The length of air bubbles was then converted to time without insulin at the lowest basal rate. Generalized linear model (GLM) was used to determine the associations between air bubble size and other variables.
Results
Of the 65 encounters, 45 had air bubbles in the tubing. Five (5/65 = 7.7%) encounters had a time without insulin of more than 60 min. Air bubble size was inversely correlated with time since infusion set change (p < 0.001), and directly correlated with age of the subject (p = 0.049).
Conclusions
Significantly more air bubbles were found in the tubing of insulin pumps soon after infusion set change and with older subjects, suggesting a relationship with the technique of filling the insulin cartridge and priming the tubing.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
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©2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Original Articles
- Air occlusion in insulin pumps of children and adolescents with type 1 diabetes
- Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus
- Adherence to multiple medications in the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) cohort: effect of additional medications on adherence to primary diabetes medication
- Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study
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- Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children
- Evidence in obese children: contribution of tri-ponderal mass index or body mass index to dyslipidemia, obesity-inflammation, and insulin sensitivity
- Prevalence of metabolic syndrome and its associated factors in overweight and obese adolescents
- Cortisol secretion pattern in overweight/obese and normal-weight infants: a cross-sectional study
- Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity
- Relative leptin deficiency in children with severe early-onset obesity (SEOO) – results of the Early-onset Obesity and Leptin – German-Polish Study (EOL-GPS)
- Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity
- The trade-off between the olfactory bulb and eyeball volume in precocious puberty
- Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents
- Presentation of 14 alkaptonuria patients from Turkey
- Assessment of health-related quality of life in Egyptian children and adolescents with congenital adrenal hyperplasia
- Case Reports
- Familial hypophosphatemic rickets caused by a PHEX gene mutation accompanied by a NPR2 missense mutation
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Articles in the same Issue
- Frontmatter
- Original Articles
- Air occlusion in insulin pumps of children and adolescents with type 1 diabetes
- Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus
- Adherence to multiple medications in the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) cohort: effect of additional medications on adherence to primary diabetes medication
- Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study
- Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity
- Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children
- Evidence in obese children: contribution of tri-ponderal mass index or body mass index to dyslipidemia, obesity-inflammation, and insulin sensitivity
- Prevalence of metabolic syndrome and its associated factors in overweight and obese adolescents
- Cortisol secretion pattern in overweight/obese and normal-weight infants: a cross-sectional study
- Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity
- Relative leptin deficiency in children with severe early-onset obesity (SEOO) – results of the Early-onset Obesity and Leptin – German-Polish Study (EOL-GPS)
- Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity
- The trade-off between the olfactory bulb and eyeball volume in precocious puberty
- Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents
- Presentation of 14 alkaptonuria patients from Turkey
- Assessment of health-related quality of life in Egyptian children and adolescents with congenital adrenal hyperplasia
- Case Reports
- Familial hypophosphatemic rickets caused by a PHEX gene mutation accompanied by a NPR2 missense mutation
- Cinacalcet treatment experience in hereditary vitamin D resistant rickets
- Can we effectively predict the occurrence of cerebral edema in children with ketoacidosis in the course of type 1 diabetes? – case report and literature review
