Evidence in obese children: contribution of tri-ponderal mass index or body mass index to dyslipidemia, obesity-inflammation, and insulin sensitivity
-
Nese Akcan
,
Moaaz Obaid
Abstract
Background
Chronic inflammation plays a critical role in the development of obesity-related metabolic dysfunction. The tri-ponderal mass index (TMI) may be more effective than body mass index (BMI) for estimating body fat levels. This study compared the efficacy of BMI and TMI in screening for dyslipidemia, insulin sensitivity, and inflammation in childhood obesity.
Methods
This study included 80 children who were classified as normal weight, overweight or obese using standardized BMI (BMI standard deviation score [SDS]) and TMI measurements. Fasting blood glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), triglycerides, total cholesterol, liver function enzymes, leptin, serum free fatty acid (FFA), fetuin-A, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), and interleukin (IL)-6 levels were evaluated using both classification systems.
Results
LDL-C levels significantly differed within the groups by BMI, and serum FFA levels differed only according to the TMI. Serum MCP-1, TNF-α, IL-6, and fetuin-A levels showed no difference according to the TMI or BMI SDS. Fetuin-A levels did not differ between the insulin-resistant and non-resistant cases. Fetuin-A was the only inflammatory marker positively correlated with BMI. No inflammatory markers correlated with TMI. Fetuin-A, MCP-1, TNF-α, and IL-6 correlated with each other, but not with metabolic parameters.
Conclusions
BMI SDS and TMI were associated with metabolic disturbances in childhood obesity. Weight versus heightn values may be related more to metabolic parameters than to inflammatory changes.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This research was supported by a grant at Near East University, Centre of Excellence, project support.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Articles in the same Issue
- Frontmatter
- Original Articles
- Air occlusion in insulin pumps of children and adolescents with type 1 diabetes
- Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus
- Adherence to multiple medications in the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) cohort: effect of additional medications on adherence to primary diabetes medication
- Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study
- Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity
- Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children
- Evidence in obese children: contribution of tri-ponderal mass index or body mass index to dyslipidemia, obesity-inflammation, and insulin sensitivity
- Prevalence of metabolic syndrome and its associated factors in overweight and obese adolescents
- Cortisol secretion pattern in overweight/obese and normal-weight infants: a cross-sectional study
- Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity
- Relative leptin deficiency in children with severe early-onset obesity (SEOO) – results of the Early-onset Obesity and Leptin – German-Polish Study (EOL-GPS)
- Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity
- The trade-off between the olfactory bulb and eyeball volume in precocious puberty
- Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents
- Presentation of 14 alkaptonuria patients from Turkey
- Assessment of health-related quality of life in Egyptian children and adolescents with congenital adrenal hyperplasia
- Case Reports
- Familial hypophosphatemic rickets caused by a PHEX gene mutation accompanied by a NPR2 missense mutation
- Cinacalcet treatment experience in hereditary vitamin D resistant rickets
- Can we effectively predict the occurrence of cerebral edema in children with ketoacidosis in the course of type 1 diabetes? – case report and literature review
Articles in the same Issue
- Frontmatter
- Original Articles
- Air occlusion in insulin pumps of children and adolescents with type 1 diabetes
- Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus
- Adherence to multiple medications in the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) cohort: effect of additional medications on adherence to primary diabetes medication
- Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study
- Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity
- Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children
- Evidence in obese children: contribution of tri-ponderal mass index or body mass index to dyslipidemia, obesity-inflammation, and insulin sensitivity
- Prevalence of metabolic syndrome and its associated factors in overweight and obese adolescents
- Cortisol secretion pattern in overweight/obese and normal-weight infants: a cross-sectional study
- Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity
- Relative leptin deficiency in children with severe early-onset obesity (SEOO) – results of the Early-onset Obesity and Leptin – German-Polish Study (EOL-GPS)
- Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity
- The trade-off between the olfactory bulb and eyeball volume in precocious puberty
- Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents
- Presentation of 14 alkaptonuria patients from Turkey
- Assessment of health-related quality of life in Egyptian children and adolescents with congenital adrenal hyperplasia
- Case Reports
- Familial hypophosphatemic rickets caused by a PHEX gene mutation accompanied by a NPR2 missense mutation
- Cinacalcet treatment experience in hereditary vitamin D resistant rickets
- Can we effectively predict the occurrence of cerebral edema in children with ketoacidosis in the course of type 1 diabetes? – case report and literature review
