Standard body mass index reference data of prepubescent diabetic Egyptian children
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Nayera E. Hassan
und
Aya Khalil
Abstract
Background:
Data on the growth of diabetic children is conflicting. The aim of this study was to create and validate acceptable body mass index (BMI)-standardized percentiles and curves applied to Egyptian prepubescent diabetic children.
Methods:
The cross-sectional study comprised 822 prepubescent children with type 1 diabetes mellitus (T1DM), whose ages ranged from 3 years to 10 years±6 months. An anthropometric assessment for each child was performed: body weight, height and BMI were calculated (weight [kg]/height [m2]), and glycated hemoglobin levels were determined. Means±standard deviations (SDs) and the smoothed percentiles of the BMI from age 3–10 years, by sex, for total, controlled and uncontrolled diabetic children were calculated. Comparisons of the 50th percentiles for the controlled and uncontrolled diabetic children, by sex, with those of the Egyptian and World Health Organization (WHO) growth curves were made.
Results:
For controlled diabetic males and females, the 50th percentile BMI was higher than those of the Egyptian and WHO growth curves, while differences in BMI were recorded for uncontrolled diabetic males and females. For uncontrolled diabetic males, the BMI was lower than the standard Egyptian and WHO growth curves up to 5 years of age, after which it became higher than the standard WHO and lower than the standard Egyptian growth curves from 5 years up to 10 years of age. Contrary to that, the BMI of uncontrolled diabetic females was higher than the standard Egyptian and WHO growth curves up to 6.5 years, between the curves from 6.5 years up to 7.5 years and then became lower than both curves up to 10 years of age.
Conclusions:
Children with T1DM should use their own BMI percentiles and never be compared with normal healthy children.
Acknowledgments
We would like to acknowledge our institute the National Research Centre, Egypt; without its support, this study could not have been done. We would also like to acknowledge the children, who were the participants of this study, and their parents and all the medical centers from where data were collected for their cooperation. Without their help, this study could not have been completed.
Author contributions: Nayera E. Hassan conceived and designed the study, Sahar A. El-Masry analyzed and interpreted the data and Aya Khalil collected the data. All authors contributed to the collection of references, drafting of the article and final approval of the version to be submitted. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Vaid S, Hanks L, Griffin R, Ashraf AP. Body mass index and glycemic control influence lipoproteins in children with type 1 diabetes. J Clin Lipidol. 2016;10:1240–7.10.1016/j.jacl.2016.07.010Suche in Google Scholar PubMed PubMed Central
2. Thrower SL, Bingley PJ. What is type 1 diabetes? Medicine 2010;38:592–6.10.1016/j.mpmed.2010.08.003Suche in Google Scholar
3. International Diabetes Federation. The IDF diabetes Atlas, 5th ed. Brussels: International Diabetes Federation, 2011.Suche in Google Scholar
4. Soltèsz G, Patterson C, Dahlquist G. Global trends in childhood type 1 diabetes. In: Diabetes Atlas, 3rd ed. Brussels: International Diabetes Federation, 2006:153–90.Suche in Google Scholar
5. El-Ziny MA, Salem NA, El-Hawary AK, Chalaby NM, Elsharkawy AA. Epidemiology of childhood type 1 diabetes mellitus in Nile Delta, northern Egypt – a retrospective study. J Clin Res Pediatr Endocrinol 2014;6:9–15.10.4274/Jcrpe.1171Suche in Google Scholar PubMed PubMed Central
6. Hassan NE, El-Awady MY. Evaluation of growth, obesity and body composition of insulin dependent diabetes mellitus children. J Arab Child 2002;13:749–54.Suche in Google Scholar
7. El-Ganzoury MM, El-Masry SA, El-Farrash RA, Mohamed MA, Abd Ellatife RZ. Infants of diabetic mothers: echocardiographic measurements and cord blood IGF-I and IGFBP-1. Pediatr Diabetes 2012;13:189–96.10.1111/j.1399-5448.2011.00811.xSuche in Google Scholar PubMed
8. Mansur Leal P, Lopes Souto D, dos Santos Lima E, Paes de Miranda M, Lopes Rosado E. Influence of fat intake on body composition, lipemia and glycemia of type 1 diabetics. Nutr Hosp 2011;26:1110–4.Suche in Google Scholar
9. Mao L, Lu W, Ji F, Lv S. Development and linear growth in diabetic children receiving insulin pigment. J Pediatr Endocrinol Metab 2011;24:433–6.10.1515/jpem.2011.204Suche in Google Scholar PubMed
10. Hyppönen E, Virtanen SM, Kenward MG, Knip M, Akerblom HK; Childhood Diabetes in Finland Study Group. Obesity, increased linear growth, and risk of type 1 diabetes in children. Diabetes Care 2000;23:1755–60.10.2337/diacare.23.12.1755Suche in Google Scholar PubMed
11. EURODIAB Substudy 2 Study Group. Rapid early growth is associated with increased risk of childhood type 1 diabetes in various European populations. Diabetes Care 2002;25: 1755–60.10.2337/diacare.25.10.1755Suche in Google Scholar PubMed
12. Knerr I, Wolf J, Reinehr T, Stachow R, Grabert M, et al. The ‘accelerator hypothesis’: relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus. Diabetologia 2005;48:2501–4.10.1007/s00125-005-0033-2Suche in Google Scholar PubMed
13. Porter JR, Barrett TG. Braking the accelerator hypothesis? Diabetologia 2004;47:352–3.10.1007/s00125-003-1291-5Suche in Google Scholar PubMed
14. O’Connell MA, Donath S, Cameron FJ. Major increase in type 1 diabetes: no support for the accelerator hypothesis. Diabet Med 2007;24:920–3.10.1111/j.1464-5491.2007.02203.xSuche in Google Scholar PubMed
15. Geiss HC, Parhofer KG, Schwandt P. Parameters of childhood obesity and their relationship to cardiovascular risk factors in healthy prepubescent children. Int J Obes Relat Metab Disord 2001;25:830–7.10.1038/sj.ijo.0801594Suche in Google Scholar PubMed
16. Lindsay RS, Hanson RL, Roumain J, Ravussin E, Knowler WC, Tataranni PA. Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy X-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab 2001;86:4061–7.10.1210/jcem.86.9.7760Suche in Google Scholar PubMed
17. Ghali I, Salah N, Hussien F, Erfan M, El-Ruby M, et al. (2002). Egyptian growth curves for infants, children and adolescents. In: Crecere nel mondo. Satorio A, Buckler JMH and Marazzi N, editors, Ferring Publisher, Italy, 2008.Suche in Google Scholar
18. World Health Organization. Obesity and overweight. Geneva, Switzerland: World Health Organization, 2006.Suche in Google Scholar
19. El-Masry SA, Hassan NE. Validity of convenient indicators of obesity. Int J Food Nutr Public Health 2010;3:83–96.10.47556/J.IJFNPH.3.1.2010.8Suche in Google Scholar
20. Hiernaux J, Tanner JM. Growth and physical studies. In: Weiner JS, Lourie SA, editors. Human biology: a guide to field methods, 2nd ed. IBP. London, Oxford: Blackwell Scientific Publications, 1969.Suche in Google Scholar
21. American Diabetes Association (ADA). Diagnosis and classification of diabetes mellitus. Diabetes Care 2007;30: s42–7.10.2337/dc07-S042Suche in Google Scholar PubMed
22. Lipsky LM, Gee B, Liu A, Nansel TR. Glycemic control and variability in association with body mass index and body composition over 18 months in youth with type 1 diabetes. Diabetes Res Clin Pract 2016;120:97–103.10.1016/j.diabres.2016.07.028Suche in Google Scholar PubMed PubMed Central
23. Hannon TS, Rogol AD. Diabetes mellitus and growth in children and adolescents. J Pediatr 2012;160:893–4.10.1016/j.jpeds.2012.01.037Suche in Google Scholar PubMed
24. El-Masry SA, El-Ganzoury MM, El-Farrash RA, Anwar M, Abd Ellatife RZ. Size at birth and insulin-like growth factor-I and its binding protein-1 among infants of diabetic mothers. J Matern Fetal Neonatal Med 2013;26:5–9.10.3109/14767058.2012.718000Suche in Google Scholar PubMed
25. Liu LL, Lawrence JM, Davis C, Liese AD, Pettitt DJ, et al. Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for Diabetes in Youth study. Pediatr Diabetes 2010;11:4–11.10.1111/j.1399-5448.2009.00519.xSuche in Google Scholar PubMed
26. Libman IM, Pietropaolo M, Arslanian SA, LaPorte RE, Becker DJ. Changing prevalence of overweight children and adolescents at onset of insulin-treated diabetes. Diabetes Care 2003;26:2871–5.10.2337/diacare.26.10.2871Suche in Google Scholar PubMed
27. Kaminski BM, Klingensmith GJ, Beck RW, Tamborlane WV, Lee J, et al. Body mass index at the time of diagnosis of autoimmune type 1 diabetes in children. J Pediatr 2013;162:736–740.e1.10.1016/j.jpeds.2012.09.017Suche in Google Scholar PubMed
28. Jackson RL, Holland E, Chatman ID, Guthrie D, Hewett JE. Growth and maturation of children with insulin-dependent diabetes mellitus. Diabetes Care 1978;1:96–107.10.2337/diacare.1.2.96Suche in Google Scholar PubMed
29. Malone JI. Growth and sexual maturation in children with insulin-dependent diabetes mellitus. Curr Opin Pediatr 1993;5:494–8.10.1097/00008480-199308000-00021Suche in Google Scholar PubMed
30. Bognetti E, Riva MC, Bonfanti R, Meschi F, Viscardi M, Chiumello G. Growth changes in children and adolescents with short-term diabetes. Diabetes Care 1998;21:1226–9.10.2337/diacare.21.8.1226Suche in Google Scholar PubMed
31. Pitukcheewanont P, Alemzadeh R, Jacobs WR, Jones BH, Eberle AJ. Does glycemic control affect growth velocity in children with insulin-dependent diabetes mellitus. Acta Diabetol 1995;32:148–52. Erratum in: Acta Diabetol 1996;33:57.10.1007/BF00838483Suche in Google Scholar PubMed
32. Lebl J, Schober E, Zidek T, Baldis S, Rami B, et al. Growth data in large series of 587 children and adolescents with type 1 diabetes mellitus. Endocr Regul 2003;37:153–61.Suche in Google Scholar
33. Herber SM, Dunsmore IR. Does control affect growth in diabetes mellitus? Acta Paediatr Scand 1988;77:303–5.10.1111/j.1651-2227.1988.tb10647.xSuche in Google Scholar PubMed
34. Wilkin TJ. The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes. Diabetologia 2001;44:914–22. Review.10.1007/s001250100548Suche in Google Scholar PubMed
35. Scheffer-Marinus PD, Links TP, Reitsma WD, Drayer NM. Increased height in diabetes mellitus corresponds to the predicted and the adult height. Acta Paediatr 1999;88:384–8.10.1111/j.1651-2227.1999.tb01126.xSuche in Google Scholar
36. Donaghue KC, Kordonouri O, Chan A, Silink M. Secular trends in growth in diabetes: are we winning? Arch Dis Child 2003;88:151–4.10.1136/adc.88.2.151Suche in Google Scholar PubMed PubMed Central
37. Heaton DA, Millward BA, Gray IP, Tun Y, Hales CN, et al. Increased proinsulin levels as early indicator of B-cell dysfunction in non-diabetic twins of type I (insulindependent) diabetic patients. Diabetologia 1988;31:182–4.10.1007/BF00276853Suche in Google Scholar PubMed
38. Blom L, Persson LA, Dahlquist G. A high linear growth is associated with an increased risk of childhood diabetes mellitus. Diabetologia 1992;35:528–33.10.1007/BF00400480Suche in Google Scholar PubMed
39. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, et al. 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 11 2002:1–190.Suche in Google Scholar
40. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. J Am Med Assoc 2012;307:483–90.10.1001/jama.2012.40Suche in Google Scholar PubMed PubMed Central
©2017 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Standard body mass index reference data of prepubescent diabetic Egyptian children
- Frequency and risk factors of depression in type 1 diabetes in a developing country
- Association of obesity and health related quality of life in Iranian children and adolescents: the Weight Disorders Survey of the CASPIAN-IV study
- Association between urinary phthalates and metabolic abnormalities in obese Thai children and adolescents
- A pilot study of the effect of human breast milk on urinary metabolome analysis in infants
- Assessment of the correlation between the atherogenic index of plasma and cardiometabolic risk factors in children and adolescents: might it be superior to the TG/HDL-C ratio?
- Cardiovascular and metabolic risk in pediatric patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency
- Application of povidone-iodine at delivery significantly increases maternal urinary iodine but not neonatal thyrotropin in an area with iodine sufficiency
- Influence of topical iodine-containing antiseptics used during delivery on recall rate of congenital hypothyroidism screening program
- Applying targeted next generation sequencing to dried blood spot specimens from suspicious cases identified by tandem mass spectrometry-based newborn screening
- Short Communication
- Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy
- Case Reports
- An occult ectopic parathyroid adenoma in a pediatric patient: a case report and management algorithm
- Fetal goitrous hypothyroidism treated by intra-amniotic levothyroxine administration: case report and review of the literature
- Carotid intima media thickness in a girl with sitosterolemia carrying a homozygous mutation in the ABCG5 gene
- Sirolimus in the treatment of three infants with diffuse congenital hyperinsulinism
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Standard body mass index reference data of prepubescent diabetic Egyptian children
- Frequency and risk factors of depression in type 1 diabetes in a developing country
- Association of obesity and health related quality of life in Iranian children and adolescents: the Weight Disorders Survey of the CASPIAN-IV study
- Association between urinary phthalates and metabolic abnormalities in obese Thai children and adolescents
- A pilot study of the effect of human breast milk on urinary metabolome analysis in infants
- Assessment of the correlation between the atherogenic index of plasma and cardiometabolic risk factors in children and adolescents: might it be superior to the TG/HDL-C ratio?
- Cardiovascular and metabolic risk in pediatric patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency
- Application of povidone-iodine at delivery significantly increases maternal urinary iodine but not neonatal thyrotropin in an area with iodine sufficiency
- Influence of topical iodine-containing antiseptics used during delivery on recall rate of congenital hypothyroidism screening program
- Applying targeted next generation sequencing to dried blood spot specimens from suspicious cases identified by tandem mass spectrometry-based newborn screening
- Short Communication
- Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy
- Case Reports
- An occult ectopic parathyroid adenoma in a pediatric patient: a case report and management algorithm
- Fetal goitrous hypothyroidism treated by intra-amniotic levothyroxine administration: case report and review of the literature
- Carotid intima media thickness in a girl with sitosterolemia carrying a homozygous mutation in the ABCG5 gene
- Sirolimus in the treatment of three infants with diffuse congenital hyperinsulinism
