Giant parathyroid adenoma associated with severe hypercalcemia in an adolescent patient
-
Kinyas Kartal
,
Nurcihan Aygun
Abstract
Background:
The objective of this study is to bring attention to the importance of differential diagnosis in adolescent patients with skeletal involvement and hypercalcemia.
Case:
A 17-year-old male patient with a complaint of severe leg pain was admitted to our hospital. Seven months before he had a fracture of his distal humerus after falling on to his left shoulder and was treated conservatively. Five months previously, he had a rupture of his quadriceps tendon. Magnetic resonance imaging (MRI) was performed for the quadriceps tendon rupture and was evaluated as polyostotic fibrous dysplasia (PFD). Doctors decided to operate for the ruptured tendon but they detected severe hypercalcemia in the pre-operative blood tests and noticed that the main disease was primary hyper-parathyroidisim (PHPT) which was caused by a giant parathyroid adenoma.
Conclusions
Giant parathyroid adenoma can present in adolescent patients with multiple bone lesions and severe hypercalcemia. PHPT should be considered in the differential diagnosis of pathological bone fractures and benign bone tumors in every age. This may prevent patients from miss or delayed diagnosis of PHPT.
Author contributions: Concept – KK, MU; Design – NA, KK; Analysis and/or interpretation: AO, KK; literature search: NA, KK; drafting article: NA, MB; critical reviews: MU. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Imaging methods for bone mass evaluation during childhood and adolescence: an update
- Original Articles
- Risk factors for overweight and obesity in children aged 2–6 years
- Copy number variations in “classical” obesity candidate genes are not frequently associated with severe early-onset obesity in children
- Trends in the prevalence of extreme obesity among Korean children and adolescents from 2001 to 2014
- Plasma but not serum brain-derived neurotrophic factor concentration is decreased by oral glucose tolerance test-induced hyperglycemia in children
- Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children
- Evaluation of vitamin D prophylaxis in 3–36-month-old infants and children
- Possible effects of neonatal vitamin B12 status on TSH-screening program: a cross-sectional study from Turkey
- Effects of L-thyroxine treatment on heart functions in infants with congenital hypothyroidism
- Hyperandrogenism in adolescent girls: relationship with the somatotrophic axis
- Plasma kisspeptin and ghrelin levels in puberty variant cases
- Genotype-phenotype correlation in paediatric pheochromocytoma and paraganglioma: a single centre experience from India
- Short Communication
- Provider variability in the initial diagnosis and treatment of congenital hypothyroidism
- Case Reports
- Giant parathyroid adenoma associated with severe hypercalcemia in an adolescent patient
- Personalized precision medicine in extreme preterm infants with transient neonatal diabetes mellitus
- Pseudohypoaldosteronism types I and II: little more than a name in common
- Primary pigmented nodular adrenocortical disease: literature review and case report of a 6-year-old boy
Articles in the same Issue
- Frontmatter
- Review
- Imaging methods for bone mass evaluation during childhood and adolescence: an update
- Original Articles
- Risk factors for overweight and obesity in children aged 2–6 years
- Copy number variations in “classical” obesity candidate genes are not frequently associated with severe early-onset obesity in children
- Trends in the prevalence of extreme obesity among Korean children and adolescents from 2001 to 2014
- Plasma but not serum brain-derived neurotrophic factor concentration is decreased by oral glucose tolerance test-induced hyperglycemia in children
- Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children
- Evaluation of vitamin D prophylaxis in 3–36-month-old infants and children
- Possible effects of neonatal vitamin B12 status on TSH-screening program: a cross-sectional study from Turkey
- Effects of L-thyroxine treatment on heart functions in infants with congenital hypothyroidism
- Hyperandrogenism in adolescent girls: relationship with the somatotrophic axis
- Plasma kisspeptin and ghrelin levels in puberty variant cases
- Genotype-phenotype correlation in paediatric pheochromocytoma and paraganglioma: a single centre experience from India
- Short Communication
- Provider variability in the initial diagnosis and treatment of congenital hypothyroidism
- Case Reports
- Giant parathyroid adenoma associated with severe hypercalcemia in an adolescent patient
- Personalized precision medicine in extreme preterm infants with transient neonatal diabetes mellitus
- Pseudohypoaldosteronism types I and II: little more than a name in common
- Primary pigmented nodular adrenocortical disease: literature review and case report of a 6-year-old boy
