Plasma kisspeptin and ghrelin levels in puberty variant cases
-
Erdal Kurnaz
,
Yaşar Şen
Abstract
Background:
The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.
Methods:
A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.
Results:
When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.
Conclusions:
Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.
Acknowledgments
We would particularly like to thank the patients who agreed to participate in this study.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: Funding for this study was provided by the Fırat University Scientific Research Projects Coordination Unit (Project no: 1849).
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Imaging methods for bone mass evaluation during childhood and adolescence: an update
- Original Articles
- Risk factors for overweight and obesity in children aged 2–6 years
- Copy number variations in “classical” obesity candidate genes are not frequently associated with severe early-onset obesity in children
- Trends in the prevalence of extreme obesity among Korean children and adolescents from 2001 to 2014
- Plasma but not serum brain-derived neurotrophic factor concentration is decreased by oral glucose tolerance test-induced hyperglycemia in children
- Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children
- Evaluation of vitamin D prophylaxis in 3–36-month-old infants and children
- Possible effects of neonatal vitamin B12 status on TSH-screening program: a cross-sectional study from Turkey
- Effects of L-thyroxine treatment on heart functions in infants with congenital hypothyroidism
- Hyperandrogenism in adolescent girls: relationship with the somatotrophic axis
- Plasma kisspeptin and ghrelin levels in puberty variant cases
- Genotype-phenotype correlation in paediatric pheochromocytoma and paraganglioma: a single centre experience from India
- Short Communication
- Provider variability in the initial diagnosis and treatment of congenital hypothyroidism
- Case Reports
- Giant parathyroid adenoma associated with severe hypercalcemia in an adolescent patient
- Personalized precision medicine in extreme preterm infants with transient neonatal diabetes mellitus
- Pseudohypoaldosteronism types I and II: little more than a name in common
- Primary pigmented nodular adrenocortical disease: literature review and case report of a 6-year-old boy
Articles in the same Issue
- Frontmatter
- Review
- Imaging methods for bone mass evaluation during childhood and adolescence: an update
- Original Articles
- Risk factors for overweight and obesity in children aged 2–6 years
- Copy number variations in “classical” obesity candidate genes are not frequently associated with severe early-onset obesity in children
- Trends in the prevalence of extreme obesity among Korean children and adolescents from 2001 to 2014
- Plasma but not serum brain-derived neurotrophic factor concentration is decreased by oral glucose tolerance test-induced hyperglycemia in children
- Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children
- Evaluation of vitamin D prophylaxis in 3–36-month-old infants and children
- Possible effects of neonatal vitamin B12 status on TSH-screening program: a cross-sectional study from Turkey
- Effects of L-thyroxine treatment on heart functions in infants with congenital hypothyroidism
- Hyperandrogenism in adolescent girls: relationship with the somatotrophic axis
- Plasma kisspeptin and ghrelin levels in puberty variant cases
- Genotype-phenotype correlation in paediatric pheochromocytoma and paraganglioma: a single centre experience from India
- Short Communication
- Provider variability in the initial diagnosis and treatment of congenital hypothyroidism
- Case Reports
- Giant parathyroid adenoma associated with severe hypercalcemia in an adolescent patient
- Personalized precision medicine in extreme preterm infants with transient neonatal diabetes mellitus
- Pseudohypoaldosteronism types I and II: little more than a name in common
- Primary pigmented nodular adrenocortical disease: literature review and case report of a 6-year-old boy
