Startseite Medizin Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease
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Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease

  • Rasha Tarif Hamza EMAIL logo , Alaa Youssef Ahmed , Doaa Gamal Rezk und Amira Ibrahim Hamed
Veröffentlicht/Copyright: 21. Juli 2016
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 29 Heft 12

Abstract

Background:

Excessive use of fructose has been incriminated as a risk factor for hepatic steatosis. Procollagen type III N-terminal peptide (P3NP) is a marker for steatohepatitis. Thus, we aimed to assess fructose intake in obese children and its relation to nonalcoholic fatty liver disease (NAFLD) and P3NP.

Methods:

Fifty-five obese children were compared to 30 controls. All were subjected to dietary fructose and anthropometric assessment, fasting blood sugar (FBS), fasting insulin (FI) and homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, uric acid, alanine aminotransferase (ALT), P3NP and abdominal ultrasound.

Results:

Patients had higher fructose intake which was associated with increased NAFLD grade. There was an increase in P3NP with increased NAFLD grade. P3NP correlated positively with fructose intake (processed sources and total) and caloric intake.

Conclusions:

High fructose intake is associated with NAFLD and P3NP may serve as a marker of NAFLD in obese children with a proposed cutoff value of 8.5 ng/mL.

Keywords: dietary; fructose; nonalcoholic fatty liver disease; obesity; procollagen type III N-terminal peptide
Corresponding author: Rasha Tarif Hamza, MD, Professor of Pediatrics and Pediatric Endocrinology, Faculty of Medicine, Ain Shams University, 36 Hisham Labib Street, Off Makram Ebeid Street, Nasr City, Cairo 11371, Egypt, Phone: +202 22734727, Fax: +202 26904430

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-1-9
Accepted: 2016-5-26
Published Online: 2016-7-21
Published in Print: 2016-12-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Non-alcoholic fatty liver disease in children and adolescents
  4. Original Articles
  5. Serum vascular endothelial cadherin and thrombomodulin are markers of non-alcoholic fatty liver disease in children
  6. Ferritin level is associated with metabolic syndrome and elevated alanine aminotransferase in children and adolescents
  7. Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease
  8. Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima – Peru 2001–2013
  9. Salivary flow rate, buffer capacity, and urea concentration in adolescents with type 1 diabetes mellitus
  10. Cortisol response to adrenocorticotropin testing in non-classical congenital adrenal hyperplasia (NCCAH)
  11. Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India
  12. Growth curves for congenital adrenal hyperplasia from a national retrospective cohort
  13. The effects of type 1 diabetes mellitus on cardiac functions in children: evaluation by conventional and tissue Doppler echocardiography
  14. The association between single nucleotide polymorphisms of the Apelin gene and diabetes mellitus in a Chinese population
  15. Case Reports
  16. Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation
  17. A case of 46,XX dysgenesis and marked tall stature; the need for caution in interpreting array comparative genomic hybridization (CGH)
  18. Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide
  19. Acknowledgment
  20. Acknowledgment
https://doi.org/10.1515/jpem-2016-0015
Schlagwörter für diesen Artikel
dietary; fructose; nonalcoholic fatty liver disease; obesity; procollagen type III N-terminal peptide

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Non-alcoholic fatty liver disease in children and adolescents
  4. Original Articles
  5. Serum vascular endothelial cadherin and thrombomodulin are markers of non-alcoholic fatty liver disease in children
  6. Ferritin level is associated with metabolic syndrome and elevated alanine aminotransferase in children and adolescents
  7. Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease
  8. Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima – Peru 2001–2013
  9. Salivary flow rate, buffer capacity, and urea concentration in adolescents with type 1 diabetes mellitus
  10. Cortisol response to adrenocorticotropin testing in non-classical congenital adrenal hyperplasia (NCCAH)
  11. Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India
  12. Growth curves for congenital adrenal hyperplasia from a national retrospective cohort
  13. The effects of type 1 diabetes mellitus on cardiac functions in children: evaluation by conventional and tissue Doppler echocardiography
  14. The association between single nucleotide polymorphisms of the Apelin gene and diabetes mellitus in a Chinese population
  15. Case Reports
  16. Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation
  17. A case of 46,XX dysgenesis and marked tall stature; the need for caution in interpreting array comparative genomic hybridization (CGH)
  18. Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide
  19. Acknowledgment
  20. Acknowledgment
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