The effects of type 1 diabetes mellitus on cardiac functions in children: evaluation by conventional and tissue Doppler echocardiography
-
Osman Ozdemir
,
Adem Yasin Koksoy
Abstract
Background:
Several studies have pointed out the existence of cardiac dysfunction in patients with type 1 diabetes mellitus (DM) even in the absence of ischemic, valvular, or hypertensive heart disease. The present study evaluated cardiac dysfunction and the relationship between severity of disease and degree of cardiac dysfunction in children with type 1 DM.
Methods:
In this prospective study, 31 patients with type 1 DM and 33 sex- and age-matched healthy children were evaluated with conventional echocardiography and tissue Doppler echocardiography (TDE). A correlation between cardiac functions and glycated hemoglobin (HbA1C) was examined.
Results:
TDE results indicated that mitral valve early diastolic annular peak flow rate (E′), mitral valve systolic flow rate (S′), ratio of mitral valve early diastolic peak flow rate to mitral valve early diastolic annular peak flow rate (E/E′), and left ventricular (LV) myocardial performance index (MPI) were higher, and LV ejection time (ET) was shorter in patients with type 1 DM (p<0.05). In addition, tricuspid valve E′ and right ventricular (RV) MPI were higher, while RV ET and tricuspid E/E′ were lower in patients with type 1 DM compared to healthy children (p<0.05).
Conclusions:
Although conventional echocardiography revealed no difference between patients with type 1 DM and healthy children, TDE showed dysfunctions of both ventricles. This state is closely related to degree of blood glucose level control. These findings signify diagnostic value of TDE in the early detection of cardiac effects among patients with type 1 DM.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Article note:
The content of the manuscript was presented at 48th Annual Meeting of the Association for European Paediatric and Congenital Cardiology, AEPC, Helsinki, Finland, May 21–24, 2014.
©2016 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial
- Non-alcoholic fatty liver disease in children and adolescents
- Original Articles
- Serum vascular endothelial cadherin and thrombomodulin are markers of non-alcoholic fatty liver disease in children
- Ferritin level is associated with metabolic syndrome and elevated alanine aminotransferase in children and adolescents
- Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease
- Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima – Peru 2001–2013
- Salivary flow rate, buffer capacity, and urea concentration in adolescents with type 1 diabetes mellitus
- Cortisol response to adrenocorticotropin testing in non-classical congenital adrenal hyperplasia (NCCAH)
- Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India
- Growth curves for congenital adrenal hyperplasia from a national retrospective cohort
- The effects of type 1 diabetes mellitus on cardiac functions in children: evaluation by conventional and tissue Doppler echocardiography
- The association between single nucleotide polymorphisms of the Apelin gene and diabetes mellitus in a Chinese population
- Case Reports
- Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation
- A case of 46,XX dysgenesis and marked tall stature; the need for caution in interpreting array comparative genomic hybridization (CGH)
- Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide
- Acknowledgment
- Acknowledgment
Artikel in diesem Heft
- Frontmatter
- Editorial
- Non-alcoholic fatty liver disease in children and adolescents
- Original Articles
- Serum vascular endothelial cadherin and thrombomodulin are markers of non-alcoholic fatty liver disease in children
- Ferritin level is associated with metabolic syndrome and elevated alanine aminotransferase in children and adolescents
- Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease
- Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima – Peru 2001–2013
- Salivary flow rate, buffer capacity, and urea concentration in adolescents with type 1 diabetes mellitus
- Cortisol response to adrenocorticotropin testing in non-classical congenital adrenal hyperplasia (NCCAH)
- Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India
- Growth curves for congenital adrenal hyperplasia from a national retrospective cohort
- The effects of type 1 diabetes mellitus on cardiac functions in children: evaluation by conventional and tissue Doppler echocardiography
- The association between single nucleotide polymorphisms of the Apelin gene and diabetes mellitus in a Chinese population
- Case Reports
- Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation
- A case of 46,XX dysgenesis and marked tall stature; the need for caution in interpreting array comparative genomic hybridization (CGH)
- Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide
- Acknowledgment
- Acknowledgment
