Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima – Peru 2001–2013
-
Miguel Angel De los Santos
,
Carlos Manuel Del Águila
Abstract
Background:
Central diabetes insipidus (CDI) is a heterogeneous disease caused by arginine vasopressin deficiency; its management implies a profound understanding of the pathophysiology and the clinical spectrum. The aim of the study was to describe the clinical characteristics that indicate organicity in children and adolescents with central diabetes insipidus treated at the Department of Endocrinology from The Child Health’s Institute during 2001 to 2013.
Methods:
Cross-sectional, retrospective study. 79 cases of patients diagnosed with CDI (51 males and 28 females) from 1 month to 16 years of age were reviewed. For the descriptive analysis, measures of central tendency and dispersion were used; groups of organic and idiopathic CDI were compared using χ2-test and t-test. A p-value<0.05 was considered significant.
Results:
The average age of patients was 8.1±4.2 years. Organic causes were intracranial tumors, 44 (55.7%), Langerhans cell histiocytosis (LCH), 11 (13.9%) and cerebral malformations in 7 (8.9%) patients, while the idiopathic group was 14 (17.7%) patients. Regarding clinical characteristics suggestive of organicity, headache (p=0.02) and visual disturbances (p=0.01) were found statistically significant. The anterior pituitary hormonal abnormalities were documented in 34 (52.3%) organic CDI patients. Furthermore, we did not find a significant difference in the average daily dose of desmopressin between patients with permanent vs. transitory CDI (0.81±0.65 vs. 0.59±0.62; p=0.363).
Conclusions:
The main clinical features suggestive of organicity in pediatric patients with central diabetes insipidus were headache and visual disturbances; furthermore, anterior pituitary hormonal abnormalities suggest an underlying organic etiology.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Non-alcoholic fatty liver disease in children and adolescents
- Original Articles
- Serum vascular endothelial cadherin and thrombomodulin are markers of non-alcoholic fatty liver disease in children
- Ferritin level is associated with metabolic syndrome and elevated alanine aminotransferase in children and adolescents
- Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease
- Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima – Peru 2001–2013
- Salivary flow rate, buffer capacity, and urea concentration in adolescents with type 1 diabetes mellitus
- Cortisol response to adrenocorticotropin testing in non-classical congenital adrenal hyperplasia (NCCAH)
- Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India
- Growth curves for congenital adrenal hyperplasia from a national retrospective cohort
- The effects of type 1 diabetes mellitus on cardiac functions in children: evaluation by conventional and tissue Doppler echocardiography
- The association between single nucleotide polymorphisms of the Apelin gene and diabetes mellitus in a Chinese population
- Case Reports
- Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation
- A case of 46,XX dysgenesis and marked tall stature; the need for caution in interpreting array comparative genomic hybridization (CGH)
- Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide
- Acknowledgment
- Acknowledgment
Articles in the same Issue
- Frontmatter
- Editorial
- Non-alcoholic fatty liver disease in children and adolescents
- Original Articles
- Serum vascular endothelial cadherin and thrombomodulin are markers of non-alcoholic fatty liver disease in children
- Ferritin level is associated with metabolic syndrome and elevated alanine aminotransferase in children and adolescents
- Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease
- Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima – Peru 2001–2013
- Salivary flow rate, buffer capacity, and urea concentration in adolescents with type 1 diabetes mellitus
- Cortisol response to adrenocorticotropin testing in non-classical congenital adrenal hyperplasia (NCCAH)
- Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India
- Growth curves for congenital adrenal hyperplasia from a national retrospective cohort
- The effects of type 1 diabetes mellitus on cardiac functions in children: evaluation by conventional and tissue Doppler echocardiography
- The association between single nucleotide polymorphisms of the Apelin gene and diabetes mellitus in a Chinese population
- Case Reports
- Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation
- A case of 46,XX dysgenesis and marked tall stature; the need for caution in interpreting array comparative genomic hybridization (CGH)
- Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide
- Acknowledgment
- Acknowledgment
