Startseite Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity

  • Ahmet Anık , Gönül Çatlı , Ayhan Abacı EMAIL logo , Tuncay Küme und Ece Bober
Veröffentlicht/Copyright: 13. Mai 2014
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 27 Heft 7-8

Abstract

Background: Nesfatin-1, a recently discovered anorexigenic peptide, is expressed in several tissues, including pancreatic islet cells and central nervous system. However, its pathophysiological role in the development of obesity and insulin resistance remains unknown.

Aim: To investigate the possible involvement of nesfatin-1 in the pathogenesis of childhood obesity, we examined the relationship between fasting and postprandial nesfatin-1 concentrations and metabolic/antropometric parameters in obese children.

Material and methods: The study included obese children with a body mass index >95th percentile. Fasting serum glucose, insulin, lipid profile, fasting and postprandial (120th min) nesfatin-1 levels were measured to evaluate the metabolic parameters. Different cutoff values for prepubertal and pubertal stages were used to determine the status of insulin resistance (HOMA-IR) (prepubertal >2.5, pubertal >4). The percentage of body fat was measured using bioelectric impedance analysis.

Results: Seventy-one obese children were included in this study. There was no statistically significant difference between fasting and postprandial nesfatin-1 levels in obese subjects (0.70±0.15 and 0.69±0.14 ng/mL, p>0.05, respectively). Insulin resistance was observed in 58% (41/71) of the cases. There was no significant difference in either fasting or postprandial serum nesfatin-1 levels between the insulin-resistant and non-resistant groups (p>0.05). There was no correlation between fasting and postprandial serum nesfatin-1 levels and anthropometric and metabolic parameters in insulin-resistant and non-resistant groups.

Conclusions: In this study, there was no significant increase in the postprandial level of nesfatin-1. This observation suggested that oral glucose load in obese children may not be sufficient for nesfatin-1 response and that nesfatin-1 may not have an effect as a short-term regulator of food intake.

Keywords: childhood; insulin resistance; nesfatin; obesity
Corresponding author: Ayhan Abaci, Assistant Professor, MD, Faculty of Medicine, Department of Pediatric Endocrinology, Dokuz Eylul University, Balcova, Izmir, 35340, Turkey, Phone: +90 232 4126076, Fax: +90 232 4126001, E-mail:

References

1. Oh I, Shimizu H, Satoh T, Okada S, Adachi S, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006;443:709–12.10.1038/nature05162Suche in Google Scholar PubMed

2. Ramanjaneya M, Chen J, Brown JE, Tripathi G, Hallschmid M, et al. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology 2010;151:3169–80.10.1210/en.2009-1358Suche in Google Scholar PubMed

3. Stengel A, Goebel M, Yakubov I, Wang L, Witcher D, et al. Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 2009;150:232–8.10.1210/en.2008-0747Suche in Google Scholar PubMed PubMed Central

4. Stengel A, Tache Y. Minireview: nesfatin-1 – an emerging new player in the brain-gut, endocrine, and metabolic axis. Endocrinology 2011;152:4033–8.10.1210/en.2011-1500Suche in Google Scholar PubMed PubMed Central

5. Konczol K, Pinter O, Ferenczi S, Varga J, Kovacs K, et al. Nesfatin-1 exerts long-term effect on food intake and body temperature. Int J Obes(Lond) 2012;36:1514–21.10.1038/ijo.2012.2Suche in Google Scholar PubMed

6. Osaki A, Shimizu H, Ishizuka N, Suzuki Y, Mori M, et al. Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats. Neurosci Lett 2012;521:46–51.10.1016/j.neulet.2012.05.056Suche in Google Scholar PubMed

7. Zhang Z, Li L, Yang M, Liu H, Boden G, et al. Increased plasma levels of nesfatin-1 in patients with newly diagnosed type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 2012;120:91–5.10.1055/s-0031-1286339Suche in Google Scholar PubMed

8. Gonzalez R, Reingold BK, Gao X, Gaidhu MP, Tsushima RG, et al. Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet beta- and MIN6 cells. J Endocrinol 2011;208:R9–16.10.1530/JOE-10-0492Suche in Google Scholar PubMed

9. Nakata M, Manaka K, Yamamoto S, Mori M, Yada T. Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet beta-cells. Endocr J 2011;58:305–13.10.1507/endocrj.K11E-056Suche in Google Scholar

10. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, et al. 2000 CDC growth charts for the United States: methods and development. Vital Health Stat11 2002;(246):1–190.Suche in Google Scholar

11. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976;51:170–9.10.1136/adc.51.3.170Suche in Google Scholar PubMed PubMed Central

12. Saldanha JF, Carrero JJ, Lobo JC, Stockler-Pinto MB, Leal VO, et al. The newly identified anorexigenic adipokine nesfatin-1 in hemodialysis patients: are there associations with food intake, body composition and inflammation? Regul Pept 2012;173:82–5.10.1016/j.regpep.2011.09.010Suche in Google Scholar PubMed

13. Valerio G, Licenziati MR, Iannuzzi A, Franzese A, Siani P, et al. Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr Metab Cardiovasc: NMCD 2006;16:279–84.10.1016/j.numecd.2005.12.007Suche in Google Scholar PubMed

14. Expert Panel on Detection E, Treatment of High Blood Cholesterol in A. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol ın adults (Adult Treatment Panel III). J Am Med Assoc 2001;285:2486–97.10.1001/jama.285.19.2486Suche in Google Scholar PubMed

15. Hatipoglu N, Ozturk A, Mazicioglu MM, Kurtoglu S, Seyhan S, et al. Waist circumference percentiles for 7- to 17-year-old Turkish children and adolescents. Eur J Pediatr 2008;167:383–9.10.1007/s00431-007-0502-3Suche in Google Scholar PubMed

16. Hickman TB, Briefel RR, Carroll MD, Rifkind BM, Cleeman JI, et al. Distributions and trends of serum lipid levels among United States children and adolescents ages 4-19 years: data from the Third National Health and Nutrition Examination Survey. Prev Med 1998;27:879–90.10.1006/pmed.1998.0376Suche in Google Scholar PubMed

17. National High Blood Pressure Education Program Working Group on High Blood Pressure in C, Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114(2 Suppl 4th Report):555–76.10.1542/peds.114.2.S2.555Suche in Google Scholar

18. American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes Care 2005;28(Suppl 1):S37–42.10.2337/diacare.28.suppl_1.S37Suche in Google Scholar PubMed

19. Abaci A, Catli G, Anik A, Kume T, Bober E. The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children. Pediatr Diabetes 2013;14:189–95.10.1111/pedi.12009Suche in Google Scholar PubMed

20. Stengel A, Hofmann T, Goebel-Stengel M, Lembke V, Ahnis A, et al. Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects. Histochem Cell Biol 2013;139:909–18.10.1007/s00418-013-1087-8Suche in Google Scholar PubMed

21. Li QC, Wang HY, Chen X, Guan HZ, Jiang ZY. Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regul Pept 2010;159:72–7.10.1016/j.regpep.2009.11.003Suche in Google Scholar PubMed

22. Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab 2009;10:355–65.10.1016/j.cmet.2009.09.002Suche in Google Scholar PubMed

23. Shimizu H, Oh I, Hashimoto K, Nakata M, Yamamoto S, et al. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology 2009;150:662–71.10.1210/en.2008-0598Suche in Google Scholar PubMed

24. Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh I, et al. Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. Clin Endocrinol (Oxf) 2010;73:484–90.10.1111/j.1365-2265.2010.03835.xSuche in Google Scholar PubMed

25. Foo KS, Brauner H, Ostenson CG, Broberger C. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. J Endocrinol 2010;204:255–63.10.1677/JOE-09-0254Suche in Google Scholar PubMed

26. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26:3160–7.10.2337/diacare.26.11.3160Suche in Google Scholar PubMed

27. Yang M, Zhang Z, Wang C, Li K, Li S, et al. Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance. Diabetes 2012;61:1959–68.10.2337/db11-1755Suche in Google Scholar PubMed PubMed Central

28. Deniz R, Gurates B, Aydin S, Celik H, Sahin I, et al. Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine 2012;42:694–9.10.1007/s12020-012-9638-7Suche in Google Scholar PubMed

Received: 2013-12-9
Accepted: 2014-3-31
Published Online: 2014-5-13
Published in Print: 2014-7-1

©2014 by Walter de Gruyter Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Welcome to Assistant Editors at JPEM
  4. Review article
  5. Common approach to childhood obesity in Japan
  6. Images in pediatric endocrinology
  7. Aromatase deficiency in an adolescent girl misdiagnosed as congenital adrenal hyperplasia in infancy and childhood
  8. Original articles
  9. Prevalence of vitamin D deficiency among Iranian adolescents
  10. Analysis of body composition among children and adolescents – a cross-sectional study of the Polish population and comparison of body fat measurement methods
  11. Association of rs8066560 variant in the sterol regulatory element-binding protein 1 (SREBP-1) and miR-33b genes with hyperglycemia and insulin resistance
  12. Differences in anxiety and depression between male and female caregivers of children with a disorder of sex development
  13. Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity
  14. The effect of growth hormone treatment on height in children with idiopathic short stature
  15. Clinical characteristics of type 1 diabetes over a 40 year period in Turkey: secular trend towards earlier age of onset
  16. Relationships of gamma-glutamyltransferase and beta 2-microglobulin on high sensitivity C-reactive protein among Japanese elementary school children
  17. Evaluation of insulin resistance and metabolic syndrome in a group of obese Czech children
  18. Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations >25 nmol/L in children
  19. Association between vitamin D level and cardiovascular risk in obese children and adolescents
  20. Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents
  21. Clinical features at diagnosis and responses to antithyroid drugs in younger children with Graves’ disease compared with adolescent patients
  22. Influence of hormonal parameters, bone mineral density and bone turnover on fracture risk in healthy male adolescents: a case control study
  23. Evaluation of lipid and glucose metabolism and cortisol and thyroid hormone levels in obese appropriate for gestational age (AGA) born and non-obese small for gestational age (SGA) born prepubertal Slovak children
  24. Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children
  25. Exhaled carbon monoxide in adolescents with diabetic cardiovascular autonomic neuropathy
  26. Gut hormone profiles in preterm and term infants during the first 2 months of life
  27. Outcome analysis of aromatase inhibitor therapy to increase adult height in males with predicted short adult stature and/or rapid pubertal progress: a retrospective chart review
  28. A deletion including exon 2 of the TSHR gene is associated with thyroid dysgenesis and severe congenital hypothyroidism
  29. Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) in childhood
  30. Patient Reports
  31. Neonatal diabetes in an infant of diabetic mother: same novel INS missense mutation in the mother and her offspring
  32. Atypical neurologic presentations of new onset type 1 diabetes mellitus in pediatric age group: a report of five unusual cases and review of the literature
  33. Importance of dietary calcium and vitamin D in the treatment of hypercalcaemia in Williams-Beuren syndrome
  34. Vitamin D intoxication in two brothers: be careful with dietary supplements
  35. Transient diabetes insipidus in a preterm neonate and the challenge of desmopressin dosing
  36. A rare case of hypoglycaemia due to insulinoma in an adolescent with acutely altered mental status
  37. Holoprosencephaly: ZIC2 mutation in a case with panhypopituitarism
  38. An association of hypochondroplasia and immune deficiency
  39. Hypophosphatemic rickets caused by a novel PHEX gene mutation in an Indian girl
  40. Psoriasis vulgaris and autoimmune polyendocrine syndrome type I: a case report
  41. Identification of a combined missense/splice-site mutation in FAH causing tyrosinemia type 1
  42. Letter to the Editor
  43. Vitamin D intake and premature infants with intraventricular hemorrhage: how advisable is it?
https://doi.org/10.1515/jpem-2013-0475
Schlagwörter für diesen Artikel
childhood; insulin resistance; nesfatin; obesity

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Welcome to Assistant Editors at JPEM
  4. Review article
  5. Common approach to childhood obesity in Japan
  6. Images in pediatric endocrinology
  7. Aromatase deficiency in an adolescent girl misdiagnosed as congenital adrenal hyperplasia in infancy and childhood
  8. Original articles
  9. Prevalence of vitamin D deficiency among Iranian adolescents
  10. Analysis of body composition among children and adolescents – a cross-sectional study of the Polish population and comparison of body fat measurement methods
  11. Association of rs8066560 variant in the sterol regulatory element-binding protein 1 (SREBP-1) and miR-33b genes with hyperglycemia and insulin resistance
  12. Differences in anxiety and depression between male and female caregivers of children with a disorder of sex development
  13. Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity
  14. The effect of growth hormone treatment on height in children with idiopathic short stature
  15. Clinical characteristics of type 1 diabetes over a 40 year period in Turkey: secular trend towards earlier age of onset
  16. Relationships of gamma-glutamyltransferase and beta 2-microglobulin on high sensitivity C-reactive protein among Japanese elementary school children
  17. Evaluation of insulin resistance and metabolic syndrome in a group of obese Czech children
  18. Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations >25 nmol/L in children
  19. Association between vitamin D level and cardiovascular risk in obese children and adolescents
  20. Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents
  21. Clinical features at diagnosis and responses to antithyroid drugs in younger children with Graves’ disease compared with adolescent patients
  22. Influence of hormonal parameters, bone mineral density and bone turnover on fracture risk in healthy male adolescents: a case control study
  23. Evaluation of lipid and glucose metabolism and cortisol and thyroid hormone levels in obese appropriate for gestational age (AGA) born and non-obese small for gestational age (SGA) born prepubertal Slovak children
  24. Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children
  25. Exhaled carbon monoxide in adolescents with diabetic cardiovascular autonomic neuropathy
  26. Gut hormone profiles in preterm and term infants during the first 2 months of life
  27. Outcome analysis of aromatase inhibitor therapy to increase adult height in males with predicted short adult stature and/or rapid pubertal progress: a retrospective chart review
  28. A deletion including exon 2 of the TSHR gene is associated with thyroid dysgenesis and severe congenital hypothyroidism
  29. Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) in childhood
  30. Patient Reports
  31. Neonatal diabetes in an infant of diabetic mother: same novel INS missense mutation in the mother and her offspring
  32. Atypical neurologic presentations of new onset type 1 diabetes mellitus in pediatric age group: a report of five unusual cases and review of the literature
  33. Importance of dietary calcium and vitamin D in the treatment of hypercalcaemia in Williams-Beuren syndrome
  34. Vitamin D intoxication in two brothers: be careful with dietary supplements
  35. Transient diabetes insipidus in a preterm neonate and the challenge of desmopressin dosing
  36. A rare case of hypoglycaemia due to insulinoma in an adolescent with acutely altered mental status
  37. Holoprosencephaly: ZIC2 mutation in a case with panhypopituitarism
  38. An association of hypochondroplasia and immune deficiency
  39. Hypophosphatemic rickets caused by a novel PHEX gene mutation in an Indian girl
  40. Psoriasis vulgaris and autoimmune polyendocrine syndrome type I: a case report
  41. Identification of a combined missense/splice-site mutation in FAH causing tyrosinemia type 1
  42. Letter to the Editor
  43. Vitamin D intake and premature infants with intraventricular hemorrhage: how advisable is it?
Jetzt anmelden und 20% sparen
Institutioneller Zugang
Wie funktioniert Authentifizierung?
Haben Sie eine Idee, wie wir unsere Website verbessern können?
Bitte schreiben Sie uns.
© 2025 De Gruyter Brill
Heruntergeladen am 17.10.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jpem-2013-0475/html?lang=de
Button zum nach oben scrollen