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Exhaled carbon monoxide in adolescents with diabetic cardiovascular autonomic neuropathy

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Published/Copyright: April 16, 2014
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 27 Issue 7-8

Abstract

The aim of the study was to determine if cardiovascular autonomic neuropathy (CAN) is associated with changed concentration of exhaled carbon monoxide (eCO) in adolescents with type 1 diabetes (T1D). A total of 46 T1D patients and 25 healthy controls (15–19 years) were enrolled. The parameters eCO and carboxyhemoglobin (HbCO) were established using a MICRO-4 Smokerlyser. CAN was examined by standard cardiovascular tests. Adolescents with T1D did not significantly differ in eCO compared to healthy subjects. eCO and HbCO were significantly lower in CAN-positive subjects (n=19) (1.36±1.65 ppm vs. 3.09±2.31, p=0.01 and 0.58±0.49% vs. 1.04±0.44, p<0.01, respectively) compared to CAN-negative subjects (n=27), whereas no significant difference was found in other measured parameters. By multivariate logistic regression, eCO and HbCO were associated with higher risk of CAN (OR=1.824, p<0.05 and OR=10.989, p<0.01). Our results indicate that eCO is decreased in CAN-positive diabetic subjects. Further studies are necessary to investigate the possible role of eCO as a marker for CAN.

Keywords: cardiovascular autonomic neuropathy; exhaled carbon monoxide; type 1 diabetes
Corresponding author: Jarmila Vojtková, MD, PhD, Department of Pediatrics, Jessenius Faculty of Medicine Comenius University and University Hospital Martin, Kollárova 2, 03601 Martin, Slovakia, Phone: +421 43 4203 254, Fax: +421 43 4222 678, E-mail:

Acknowledgments

The study was supported by project “Centre of Experimental and Clinical Respirology, CEKR II”, co-financed by EU sources.

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Received: 2013-10-11
Accepted: 2014-2-28
Published Online: 2014-4-16
Published in Print: 2014-7-1

©2014 by Walter de Gruyter Berlin/Boston

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  3. Welcome to Assistant Editors at JPEM
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  14. The effect of growth hormone treatment on height in children with idiopathic short stature
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https://doi.org/10.1515/jpem-2013-0401
Keywords for this article
cardiovascular autonomic neuropathy; exhaled carbon monoxide; type 1 diabetes

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Welcome to Assistant Editors at JPEM
  4. Review article
  5. Common approach to childhood obesity in Japan
  6. Images in pediatric endocrinology
  7. Aromatase deficiency in an adolescent girl misdiagnosed as congenital adrenal hyperplasia in infancy and childhood
  8. Original articles
  9. Prevalence of vitamin D deficiency among Iranian adolescents
  10. Analysis of body composition among children and adolescents – a cross-sectional study of the Polish population and comparison of body fat measurement methods
  11. Association of rs8066560 variant in the sterol regulatory element-binding protein 1 (SREBP-1) and miR-33b genes with hyperglycemia and insulin resistance
  12. Differences in anxiety and depression between male and female caregivers of children with a disorder of sex development
  13. Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity
  14. The effect of growth hormone treatment on height in children with idiopathic short stature
  15. Clinical characteristics of type 1 diabetes over a 40 year period in Turkey: secular trend towards earlier age of onset
  16. Relationships of gamma-glutamyltransferase and beta 2-microglobulin on high sensitivity C-reactive protein among Japanese elementary school children
  17. Evaluation of insulin resistance and metabolic syndrome in a group of obese Czech children
  18. Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations >25 nmol/L in children
  19. Association between vitamin D level and cardiovascular risk in obese children and adolescents
  20. Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents
  21. Clinical features at diagnosis and responses to antithyroid drugs in younger children with Graves’ disease compared with adolescent patients
  22. Influence of hormonal parameters, bone mineral density and bone turnover on fracture risk in healthy male adolescents: a case control study
  23. Evaluation of lipid and glucose metabolism and cortisol and thyroid hormone levels in obese appropriate for gestational age (AGA) born and non-obese small for gestational age (SGA) born prepubertal Slovak children
  24. Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children
  25. Exhaled carbon monoxide in adolescents with diabetic cardiovascular autonomic neuropathy
  26. Gut hormone profiles in preterm and term infants during the first 2 months of life
  27. Outcome analysis of aromatase inhibitor therapy to increase adult height in males with predicted short adult stature and/or rapid pubertal progress: a retrospective chart review
  28. A deletion including exon 2 of the TSHR gene is associated with thyroid dysgenesis and severe congenital hypothyroidism
  29. Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) in childhood
  30. Patient Reports
  31. Neonatal diabetes in an infant of diabetic mother: same novel INS missense mutation in the mother and her offspring
  32. Atypical neurologic presentations of new onset type 1 diabetes mellitus in pediatric age group: a report of five unusual cases and review of the literature
  33. Importance of dietary calcium and vitamin D in the treatment of hypercalcaemia in Williams-Beuren syndrome
  34. Vitamin D intoxication in two brothers: be careful with dietary supplements
  35. Transient diabetes insipidus in a preterm neonate and the challenge of desmopressin dosing
  36. A rare case of hypoglycaemia due to insulinoma in an adolescent with acutely altered mental status
  37. Holoprosencephaly: ZIC2 mutation in a case with panhypopituitarism
  38. An association of hypochondroplasia and immune deficiency
  39. Hypophosphatemic rickets caused by a novel PHEX gene mutation in an Indian girl
  40. Psoriasis vulgaris and autoimmune polyendocrine syndrome type I: a case report
  41. Identification of a combined missense/splice-site mutation in FAH causing tyrosinemia type 1
  42. Letter to the Editor
  43. Vitamin D intake and premature infants with intraventricular hemorrhage: how advisable is it?
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