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Gut hormone profiles in preterm and term infants during the first 2 months of life

  • Ryou Kawamata EMAIL logo , Yume Suzuki , Yukari Yada , Yasunori Koike , Yumi Kono , Toshihiko Yada and Naoto Takahashi
Published/Copyright: February 27, 2014
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 27 Issue 7-8

Abstract

Aim: To investigate changes of gut hormones in term and preterm infants in the first 2 months after birth, as the role and relationships of gut hormones in premature infants has not been well elucidated.

Methods: In 29 preterm and five term infants, fasting serum concentrations of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin, and ghrelin were measured using a bead array system.

Results: Serum leptin concentration soon after birth showed a positive correlation with gestational week in all infants (r=0.623, p<0.01). Serum leptin level rapidly decreased in all infants. In preterm infants, serum GLP-1 levels at birth showed negative correlations with gestational week (r=–0.447, p=0.02). Serum GIP, GLP-1, and PYY levels increased after birth and were persistently high until 10 weeks of life.

Conclusion: Serum concentrations of different gut hormones changed postnatally in their specific ways in preterm infants.

Keywords: glucagon-like peptide-1; glucose-dependent insulinotropic polypeptide; leptin; neonates; pancreatic polypeptide; peptide YY; premature infants
Corresponding author: Ryou Kawamata, MD, Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan, Phone: +81-285-58-7366, Fax: +81-285-44-6123, E-mail:

Acknowledgments

This study was supported by a Grant-in-Aid for Young Scientists (B) No. 21791039 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.

Conflict of interest statement: The authors have no conflicts of interest to disclose.

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Received: 2013-12-12
Accepted: 2014-1-14
Published Online: 2014-2-27
Published in Print: 2014-7-1

©2014 by Walter de Gruyter Berlin/Boston

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  2. Editorial
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  4. Review article
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https://doi.org/10.1515/jpem-2013-0385
Keywords for this article
glucagon-like peptide-1; glucose-dependent insulinotropic polypeptide; leptin; neonates; pancreatic polypeptide; peptide YY; premature infants

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Welcome to Assistant Editors at JPEM
  4. Review article
  5. Common approach to childhood obesity in Japan
  6. Images in pediatric endocrinology
  7. Aromatase deficiency in an adolescent girl misdiagnosed as congenital adrenal hyperplasia in infancy and childhood
  8. Original articles
  9. Prevalence of vitamin D deficiency among Iranian adolescents
  10. Analysis of body composition among children and adolescents – a cross-sectional study of the Polish population and comparison of body fat measurement methods
  11. Association of rs8066560 variant in the sterol regulatory element-binding protein 1 (SREBP-1) and miR-33b genes with hyperglycemia and insulin resistance
  12. Differences in anxiety and depression between male and female caregivers of children with a disorder of sex development
  13. Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity
  14. The effect of growth hormone treatment on height in children with idiopathic short stature
  15. Clinical characteristics of type 1 diabetes over a 40 year period in Turkey: secular trend towards earlier age of onset
  16. Relationships of gamma-glutamyltransferase and beta 2-microglobulin on high sensitivity C-reactive protein among Japanese elementary school children
  17. Evaluation of insulin resistance and metabolic syndrome in a group of obese Czech children
  18. Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations >25 nmol/L in children
  19. Association between vitamin D level and cardiovascular risk in obese children and adolescents
  20. Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents
  21. Clinical features at diagnosis and responses to antithyroid drugs in younger children with Graves’ disease compared with adolescent patients
  22. Influence of hormonal parameters, bone mineral density and bone turnover on fracture risk in healthy male adolescents: a case control study
  23. Evaluation of lipid and glucose metabolism and cortisol and thyroid hormone levels in obese appropriate for gestational age (AGA) born and non-obese small for gestational age (SGA) born prepubertal Slovak children
  24. Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children
  25. Exhaled carbon monoxide in adolescents with diabetic cardiovascular autonomic neuropathy
  26. Gut hormone profiles in preterm and term infants during the first 2 months of life
  27. Outcome analysis of aromatase inhibitor therapy to increase adult height in males with predicted short adult stature and/or rapid pubertal progress: a retrospective chart review
  28. A deletion including exon 2 of the TSHR gene is associated with thyroid dysgenesis and severe congenital hypothyroidism
  29. Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) in childhood
  30. Patient Reports
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  33. Importance of dietary calcium and vitamin D in the treatment of hypercalcaemia in Williams-Beuren syndrome
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  38. An association of hypochondroplasia and immune deficiency
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  41. Identification of a combined missense/splice-site mutation in FAH causing tyrosinemia type 1
  42. Letter to the Editor
  43. Vitamin D intake and premature infants with intraventricular hemorrhage: how advisable is it?
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