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Skeletal maturation and predicted adult height in children with premature adrenarche

  • Shilpa Gurnurkar EMAIL logo , Kristopher L. Arheart , Sarah E. Messiah , Aimee Mankodi and Adriana Carrillo
Published/Copyright: August 20, 2013
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 27 Issue 1-2

Abstract

Objective: Premature adrenarche (PA) may be associated with obesity and advanced bone age. Our objective was to determine if children with PA had a predicted adult height less than target height.

Methods: A retrospective chart review identified 100 children originating predominantly from South and Central America and the Caribbean region previously diagnosed with PA from one pediatric endocrinology clinic.

Results: The majority (89.2%) of the sample had advanced bone age, while 43.4% were obese and 41.8% had a predicted height below target. There was a significant correlation between body mass index Z-score and bone age advancement among boys (r=0.67, p<0.001). The majority (72.7%) of those with a predicted height below target had a bone age advancement of two standard deviations or more.

Conclusions: These findings suggest that PA and obesity are associated with rapid skeletal maturation and that significant bone age advancement in PA is associated with a sub-optimal adult height.

Keywords: bone age; obesity; predicted adult height; premature adrenarche
Corresponding author: Shilpa Gurnurkar, University of Miami Leonard M. Miller School of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Mailman Center for Child Development, 1601 NW 12th Ave, Suite 3044A, Miami, FL 33136, USA, Phone: +1-305-243-5707, Fax: +1-305-243-6309, E-mail:

This work was supported by National Institutes of Health grant K01 DA 026993 (SEM). We would like to thank Maria Y. Marin and M. Sunil Mathew for database management. We would also like to thank Dr. Gary Berkovitz for reviewing the manuscript.

Conflicts of interests: The authors have no conflicts of interests to disclose.

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Received: 2013-5-20
Accepted: 2013-7-22
Published Online: 2013-08-20
Published in Print: 2014-01-01

©2014 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2013-0199
Keywords for this article
bone age; obesity; predicted adult height; premature adrenarche

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorials
  4. Editorial
  5. Consensus, guidelines and reviews
  6. Review article
  7. Adaptation of glucose metabolism to fasting in young children with infectious diseases: a perspective
  8. Images in pediatric endocrinology
  9. Coexistence of testicular microlithiasis with parathyroid adenoma in an obese child
  10. Original articles
  11. Remission of hypertension and electrolyte abnormalities following renal transplantation in a patient with apparent mineralocorticoid excess well documented throughout childhood
  12. Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: a pilot study
  13. Glycemic control in familial vs. sporadic type 1 diabetes patients over 5 years
  14. Clinical and laboratory features of temporary brittle bone disease
  15. Age of thelarche and menarche in contemporary US females: a cross-sectional analysis
  16. Teriparatide (rhPTH) treatment in children with syndromic hypoparathyroidism
  17. Retinol and retinyl palmitate in fetal mice liver: sexual dimorphism
  18. Skeletal maturation and predicted adult height in children with premature adrenarche
  19. Homozygosity for a DTDST mutation in a child with multiple epiphyseal dysplasia
  20. Body composition in young patients with galactose metabolic disorders: a preliminary report
  21. Detection of vascular risk markers in children and adolescents with type 1 diabetes
  22. X-linked recessive nephrogenic diabetes insipidus: a clinico-genetic study
  23. Factors influencing neonatal thyroid-stimulating hormone concentrations as a measure of population iodine status
  24. Pediatric idiopathic intracranial hypertension and the underlying endocrine-metabolic dysfunction: a pilot study
  25. Patient reports
  26. Hypothalamic hamartoma associated with central precocious puberty and growth hormone deficiency
  27. A pediatric patient with Cushing syndrome caused by ectopic ACTH syndrome and concomitant pituitary incidentalomas
  28. A novel genetic mutation in a Portuguese family with GCK-MODY
  29. Permanent neonatal diabetes mellitus in monozygotic twins achieving low-dose sulfonylurea therapy
  30. Hypocalcemia in a paediatric case: from the clinical features to diagnosis
  31. A rare case of osteogenesis imperfecta combined with complete tooth loss
  32. Iatrogenic acute pancreatitis due to hypercalcemia in a child with pseudohypoparathyroidism
  33. Clinical expression of familial Williams-Beuren syndrome in a Turkish family
  34. The first report of cabergoline-induced immune hemolytic anemia in an adolescent with prolactinoma
  35. Low-level hyperinsulinism with hypoglycemic spells in an infant with mosaic Turner syndrome and mild Kabuki-like phenotype: a case report and review of the literature
  36. Multiple cutaneous hemangiomas in a patient with combined pituitary hormone deficiency
  37. Premature thelarche related to fennel tea consumption?
  38. A novel insertion in the FOXL2 gene in a Chilean patient with blepharophimosis ptosis epicanthus inversus syndrome type I
  39. Zellweger syndrome: prenatal and postnatal growth failure with epiphyseal stippling
  40. Marine-Lenhart syndrome in a young girl
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  44. Carotid intima media thickness and echocardiography in risk stratification of obese adolescents with non-alcoholic fatty liver disease: what is the “right” approach?
  45. Vitamin D and the heart: what is the truth?
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