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Absence of diabetes mellitus type 2 in obese children and adolescents in the north of Spain
-
Aníbal Aguayo
Veröffentlicht/Copyright:
6. Dezember 2012
Abstract
Background: The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of carbohydrate metabolism disorders.
Objective: To determine the prevalence of type 2 diabetes mellitus (T2DM) and other carbohydrate metabolism disorders in obese young people in the Basque Country (Spain).
Design: Prospective observational study.
Patients: We studied 136 obese Caucasian children and adolescents (body mass index ≥2 SDS above the mean).
Measurements: Their severity of obesity was classified as mild <3 SDS or moderate-to-severe ≥3 SDS. Data were collected on clinical and metabolic parameters; insulin resistance (IR) was calculated using the homeostasis model assessment, and an oral glucose tolerance test (OGTT) was carried out.
Results: T2DM was not found. Impaired glucose tolerance (IGT) was found in 9.6% of patients being higher in moderate-to-severe obesity (12.8% vs. 2.4%; p=0.048) and in patients with acanthosis nigricans (27.8% vs. 6.8%; p=0.016). No differences were detected by sex or pubertal development in metabolic results as a function of OGTT’s response. IR (13.5%) was higher among those with moderate-to-severe obesity, in patients with acanthosis nigricans and was associated with other cardiovascular disease risk factors.
Conclusions: We found no children with T2DM. The prevalence of IGT and IR was related to severity of obesity, to the association of acanthosis nigricans and was associated with cardiovascular risk.
Received: 2012-6-21
Accepted: 2012-10-5
Published Online: 2012-12-06
Published in Print: 2013-02-01
©2013 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
childhood;
glucose intolerance;
insulin resistance;
obesity;
type 2 diabetes mellitus
Artikel in diesem Heft
- Masthead
- Masthead
- Review Article
- Clinical and diagnostic characteristics of hyperprolactinemia in childhood and adolescence
- Images in Pediatric Endocrinology
- Early occurrence of cerebral white matter abnormality detected in a neonate with salt-wasting congenital adrenal hyperplasia
- Original Articles
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- Ceramide mediates inhibition of the Akt/eNOS pathway by high levels of glucose in human vascular endothelial cells
- Short- and middle-term continuous use of cinacalcet in children on peritoneal dialysis
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- Celiac disease and dermatitis herpetiformis in Brazilian twins: a long-term follow-up and screening of their relatives
- Glucocorticoid receptor expression in whole blood with preterm infants
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- Attempted suicide with levothyroxine in an adolescent girl
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- Brothers with germline PTEN mutations and persistent hypoglycemia, macrocephaly, developmental delay, short stature, and coagulopathy
- DEND syndrome due to V59A mutation in KCNJ11 gene: unresponsive to sulfonylureas
- Severe short stature due to 3-M syndrome with a novel OBSL1 gene mutation
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