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Octreotide-induced hepatitis in a child with persistent hyperinsulinemia hypoglycemia of infancy
-
Josef Ben-Ari
Published/Copyright:
January 17, 2013
Abstract
Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), the most common cause of persistent hypoglycemia in the neonatal period and infancy, is a genetic disorder characterized by abnormal regulation of insulin secretion. Octreotide, a somatostatin analog, is often used as a second-line treatment when diazoxide therapy fails to control hypoglycemia. We report herein a rare development of octreotide-induced hepatitis following prolonged treatment for PHHI in an infant. Octreotide-induced hepatitis may occur mostly when high doses are given, or when dosing is increased. This warrants routine examination of liver function. When hepatitis develops, prompt cessation of octreotide therapy will probably result in subsequent resolution.
Keywords: drug related liver injury; hyperinsulinism
Received: 2012-10-25
Accepted: 2012-11-12
Published Online: 2013-01-17
Published in Print: 2013-02-01
©2013 by Walter de Gruyter Berlin Boston
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