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Short- and middle-term continuous use of cinacalcet in children on peritoneal dialysis
-
John Dotis
,
Nikoleta Printza
Published/Copyright:
October 25, 2012
Abstract
Background: Secondary hyperparathyroidism (HPT) constitute a high-turnover bone disease, manifested by elevated parathyroid hormone. Cinacalcet, belonging to calcimimetics, has been shown to be promising in the control of secondary HPT with limited data in children.
Objective: To evaluate the safety and efficacy of cinacalcet in children on peritoneal dialysis (PD) with secondary HPT.
Methods: Four patients on PD with severe secondary HPT, uncontrolled with phosphorus dietary restrictions combined with phosphate binders and analog of 1,25 vitamin D3 received cinacalcet.
Results: After cinacalcet treatment, in two of four patients, we found a serum intact parathyroid hormone (iPTH) level reduction by more than 70% at 4 weeks and more than 60% at 3 or more than 6 months. Nevertheless, in the other two patients, a transient reduction of iPTH was found in 4 weeks and an increase in 3 or more months, who were finally treated with surgical parathyroidectomy. During cinacalcet treatment, no adverse events were noted.
Conclusion: Cinacalcet may be a safe and effective treatment for PD patients with secondary HPT, although surgical parathyroidectomy cannot be avoided in certain cases.
Keywords: cinacalcet; peritoneal dialysis; secondary hyperparathyroidism; surgical parathyroidectomy
Received: 2012-7-3
Accepted: 2012-9-17
Published Online: 2012-10-25
Published in Print: 2013-02-01
©2013 by Walter de Gruyter Berlin Boston
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Keywords for this article
cinacalcet;
peritoneal dialysis;
secondary hyperparathyroidism;
surgical parathyroidectomy
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