Effect of ozone gas on viral kinetics and liver histopathology in hepatitis C patients
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Ahmed Sadek
and
Eman R. Youness
Abstract
Objectives
We examine how well ozone/oxygen gas therapy treats chronic hepatitis C patients with varying degrees of liver fibrosis. Also to study the effect of giving multiple anti-oxidants with the ozone/oxygen gas mixture, to see if this addition would have any additive or synergistic effect.
Methods
Two hundred and twenty three patients with chronic hepatitis C. Liver biopsies were carried out at after 12 weeks of administering an ozone/oxygen gas mixture.
Results
The mean stage of fibrosis decreased from 1.98 to 1.41 and the mean grade of inflammation decreased from 10.08 to 7.94, both with a p value less than 0.001. After 12 weeks of treatment, mean PCR values increased. No single significant complication was recorded in a total of >9,000 settings of ozone therapy.
Conclusions
Ozone oxygen gas mixture is safe and effective in treatment of hepatic fibrosis due to chronic viral hepatitis C.
Funding source: no funding
Acknowledgments
We thank all the participants.
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Research ethics: Approval of the ethics committee at the Theodor Bilharz Research Institute was taken prior to the study (registration number FWA 00010609).
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Informed consent: Written Consents was obtained from each participant in the current study.
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Author contributions: SA conceived the study, AAM Collected and Perform Experiment, HO did histopathological studies and supervised the study, AAA did PCR, EH reviewed the manuscript. MZ wrote, reviewed and proof read the final manuscript. ERY did the biochemical analysis, ERY, WW and SMA prepared and revised the manuscript.
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Competing interests: The authors state not conflict of interest.
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Research funding: None declared.
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Data availability: The data and materials used in this study are available upon request from the authors.
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Articles in the same Issue
- Frontmatter
- Reviews
- Markhamia lutea leaves aqueous and ethanolic extract with curative anti-inflammatory activity attenuates paclitaxel toxicity in rat’s intestine
- Does hydrotherapy influence plasma glucose levels in type 2 diabetes? – A scoping review
- Comparative effectiveness is the common denominator in health services research: experimental effects are promising, real-world effects are compelling
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- Hydroethanolic extract of Piliostigma thonningii leaves extenuates the severity of diarrhoea in female Wistar rats
- Pharmacokinetic assessment of rifampicin and des-acetyl rifampicin in carbon tetrachloride induced liver injury model in Wistar rats
- Antipyretic activity of the hydro-alcoholic extract of Artemisia absinthium L. as a standalone and as an adjuvant with barley water against yeast-induced pyrexia in albino Wistar rats
- Selenium prevented renal tissue damage in lipopolysaccharide-treated rats
- Preliminary data on cytotoxicity and functional group assessment of a herb–mineral combination against colorectal carcinoma cell line
- Oral intake of collagen hydrolysate from mackerel scad (Decapterus macarellus) attenuates skin photoaging by suppressing the UVB-induced expression of MMP-1 and IL-6
- Pentaclethra macrophylla leaves reduce blood glucose level, improve sexual behavior and modulate critical enzymes associated with diabetes-erectile dysfunction morbidity in rats
- Anti-melanoma and antioxidant properties of the methanol extract from the leaves of Phragmenthera capitata (Spreng.) Balle and Globimetula braunii (Engl.) Van Tiegh
- The assessment of the mechanism of action of lauric acid in the context of oral cancer through integrative approach combining network pharmacology and molecular docking technology
- Therapeutic potential of flavonoids in ovalbumin induced asthma in mice model
- The effects of pioglitazone and rosiglitazone on liver function in hypothyroid rats
- Effect of ozone gas on viral kinetics and liver histopathology in hepatitis C patients
