Startseite Evaluation of different almond (Terminalia catappa) extracts against oxidative stress induced by cyclosporine in brain and liver of rats
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Evaluation of different almond (Terminalia catappa) extracts against oxidative stress induced by cyclosporine in brain and liver of rats

  • Felix Abayomi Dada ORCID logo EMAIL logo , Sunday Idowu Oyeleye , Stephen Adeniyi Adefegha , Leye Jonathan Babatola und Adeniyi Adebayo
Veröffentlicht/Copyright: 13. April 2021
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 18 Heft 4

Abstract

Objectives

This study was designed to evaluate the ameliorative effect of almond (Terminalia catappa) leaf (ALE) and stem bark (ABE) extracts on the enzyme activities and oxidative stress markers in the brain and liver tissues of cyclosporine-A (CsA) stressed male albino rats.

Methods

Eighty-eight adult male rats weighing between 200 and 220 g were randomly distributed to into 11 groups (n=8) and different doses (100 and 200 mg/kg bwt.) of ALE and ABE were administered through oral gavages to the normal rats and 50 mg/kg/bwt/day CsA-stressed, while normal control rats was given a saline solution (p.o), and the treatment lasted for 14 days. Blood plasma, liver and brain tissues were prepared for biochemical analysis.

Results

Neuronal [acetylcholinesterase (AChE) and butrylcholinesterase (BChE) and arginase] enzyme activities and thiobarbituric acid reactive species (TBARS) level, plasma aspartate transferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities, liver non-protein thiol (NPSH) level were analyzed. The results revealed that, the administration of CsA induced a significant increase in neuronal AChE, BChE, arginase, TBARS level, but decreased nitric oxide (NO) level. CsA also increased ALT, AST, and ALP activities in the blood plasma of CsA stress rats compared to normal control, but were significantly reversed respectively (p<0.001) upon treatment with the ALE and ABE dose-dependently.

Conclusions

The study revealed that ALE and ABE could prevent neuronal dysfunction and liver toxicity induced by CsA administration, however, higher dose (200 mg/kg) of the studied extracts appears to be more potent.

Keywords: almond extracts; antioxidants; cyclosporine-A; hepatotoxicity; neurotoxicity; oxidative stress
Corresponding author: Felix Abayomi Dada, Science Laboratory Technology Department (Biochemistry Unit), Federal Polytechnic Ede, P.M.B 231, Ede, Osun State, Nigeria, Phone: +2348067509611, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: No funding organizations played a role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Ethical approval: The study was approved by the Centre for Research and Development (CERAD) of Federal University of Technology, Akure (FUTA), with ethical no FUTA/ETH/011.

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Received: 2020-05-22
Accepted: 2020-09-21
Published Online: 2021-04-13

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Articles
  3. Vestibular stimulation: a noninvasive brain stimulation in Parkinson’s disease & its implications
  4. Preventive aspect of ayurveda and yoga towards newly emerging disease COVID-19
  5. Efficacy of prayer in inducing immediate physiological changes: a systematic analysis of objective experiments
  6. Research Articles
  7. Antilithiatic activity of a non-pharmacopoeial Unani formulation in chemically induced urolithiasis in rats
  8. Immunomodulatory and antioxidant activity from Indonesian anti-degenerative herbs water extract
  9. Intracerebroventricular injection of propranolol blocked analgesic and neuroprotective effects of resveratrol following L5 spinal nerve ligation in rat
  10. Possible involvement of the dopamine D2 receptors of ventromedial hypothalamus in the control of free- and scheduled-feeding and plasma ghrelin level in rat
  11. S-methyl cysteine sulfoxide mitigates histopathological damage, alleviate oxidative stress and promotes immunomodulation in diabetic rats
  12. Evaluation of different almond (Terminalia catappa) extracts against oxidative stress induced by cyclosporine in brain and liver of rats
  13. Stigmasterol isolated from the chloroform fraction of Adenopus breviflorus Benth fruit induces mitochondrial-dependent apoptosis in rat liver
  14. Uterine contractile activity and fetal outcome in rats treated with vitamin C during late gestational variable stress exposure
  15. Sub-chronic toxicological evaluation of Strophanthus hispidus DC (Apocynaceae) aqueous root extract
  16. Beneficial consequences of probiotic on mitochondrial hippocampus in Alzheimer’s disease
  17. Avocado/soy unsaponifiables can redress the balance between serum antioxidant and oxidant levels in patients with osteoarthritis: a double-blind, randomized, placebo-controlled, cross-over study
  18. The effects of combination of Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial
  19. Efficacy of Khār-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial
  20. Comparison of the effect of Ceratonia siliqua L. fruit oral capsule and vitamin E on semen parameters in men with idiopathic infertility: a triple-blind randomized controlled clinical trial
  21. Effect of dry cupping versus soft and prolonged massage in the management of knee osteoarthritis – a randomized controlled clinical trial
  22. Use of complementary and alternative medicines (CAM) among Malaysian cancer patients for the management of chemotherapy related side effects (CRSE)
  23. Correlation between gastrointestinal symptoms and adherence to traditional Persian medicine dietary recommendations in patients with vitiligo; a cross-sectional study
  24. Effects of Tai Chi and running on blood oxygen saturation: a pilot study
  25. The effect of spiritual care on quality of life of patients with amputation caused by diabetes type 2: a clinical trial
  26. The effect of acupressure on the level of the blood pressure, respiratory rate, and heart rate in patients with the brain contusion under mechanical ventilation
  27. The effects of foot massage on hemodialysis patients’ sleep quality and restless leg syndrome: a comparison of lavender and sweet orange essential oil topical application
  28. Evaluation of reproductive hormones in Egyptian workers occupationally exposed to di-2-ethylhexyl phthalate (DEHP): a cross-sectional study
  29. Case Reports
  30. Normalisation of human chorionic gonadotrophin (hCG) levels in a patient with partial molar pregnancy with a uterine mass without chemotherapy: impact of using herbal remedies
  31. Herbal supplement (Combi-5) in the management of COVID 19 individual with mild to moderate symptoms: a case report
  32. Effect of yoga and naturopathy on disease activity and symptom burdens in a patient with active ulcerative colitis: a case report
  33. Letter to the Editor
  34. Does the article titled “Hot arm and foot bath on heart rate variability and blood pressure in healthy volunteers – needs to be verified with standard device?” Have reporting bias?
  35. Abstracts
  36. 1st International Virtual Conference on Integrative Medicine 2021 (ICIM 2021) in conjunction with the 4th International Biohealth Science Conference
https://doi.org/10.1515/jcim-2020-0193
Schlagwörter für diesen Artikel
almond extracts; antioxidants; cyclosporine-A; hepatotoxicity; neurotoxicity; oxidative stress

Artikel in diesem Heft

  1. Frontmatter
  2. Review Articles
  3. Vestibular stimulation: a noninvasive brain stimulation in Parkinson’s disease & its implications
  4. Preventive aspect of ayurveda and yoga towards newly emerging disease COVID-19
  5. Efficacy of prayer in inducing immediate physiological changes: a systematic analysis of objective experiments
  6. Research Articles
  7. Antilithiatic activity of a non-pharmacopoeial Unani formulation in chemically induced urolithiasis in rats
  8. Immunomodulatory and antioxidant activity from Indonesian anti-degenerative herbs water extract
  9. Intracerebroventricular injection of propranolol blocked analgesic and neuroprotective effects of resveratrol following L5 spinal nerve ligation in rat
  10. Possible involvement of the dopamine D2 receptors of ventromedial hypothalamus in the control of free- and scheduled-feeding and plasma ghrelin level in rat
  11. S-methyl cysteine sulfoxide mitigates histopathological damage, alleviate oxidative stress and promotes immunomodulation in diabetic rats
  12. Evaluation of different almond (Terminalia catappa) extracts against oxidative stress induced by cyclosporine in brain and liver of rats
  13. Stigmasterol isolated from the chloroform fraction of Adenopus breviflorus Benth fruit induces mitochondrial-dependent apoptosis in rat liver
  14. Uterine contractile activity and fetal outcome in rats treated with vitamin C during late gestational variable stress exposure
  15. Sub-chronic toxicological evaluation of Strophanthus hispidus DC (Apocynaceae) aqueous root extract
  16. Beneficial consequences of probiotic on mitochondrial hippocampus in Alzheimer’s disease
  17. Avocado/soy unsaponifiables can redress the balance between serum antioxidant and oxidant levels in patients with osteoarthritis: a double-blind, randomized, placebo-controlled, cross-over study
  18. The effects of combination of Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial
  19. Efficacy of Khār-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial
  20. Comparison of the effect of Ceratonia siliqua L. fruit oral capsule and vitamin E on semen parameters in men with idiopathic infertility: a triple-blind randomized controlled clinical trial
  21. Effect of dry cupping versus soft and prolonged massage in the management of knee osteoarthritis – a randomized controlled clinical trial
  22. Use of complementary and alternative medicines (CAM) among Malaysian cancer patients for the management of chemotherapy related side effects (CRSE)
  23. Correlation between gastrointestinal symptoms and adherence to traditional Persian medicine dietary recommendations in patients with vitiligo; a cross-sectional study
  24. Effects of Tai Chi and running on blood oxygen saturation: a pilot study
  25. The effect of spiritual care on quality of life of patients with amputation caused by diabetes type 2: a clinical trial
  26. The effect of acupressure on the level of the blood pressure, respiratory rate, and heart rate in patients with the brain contusion under mechanical ventilation
  27. The effects of foot massage on hemodialysis patients’ sleep quality and restless leg syndrome: a comparison of lavender and sweet orange essential oil topical application
  28. Evaluation of reproductive hormones in Egyptian workers occupationally exposed to di-2-ethylhexyl phthalate (DEHP): a cross-sectional study
  29. Case Reports
  30. Normalisation of human chorionic gonadotrophin (hCG) levels in a patient with partial molar pregnancy with a uterine mass without chemotherapy: impact of using herbal remedies
  31. Herbal supplement (Combi-5) in the management of COVID 19 individual with mild to moderate symptoms: a case report
  32. Effect of yoga and naturopathy on disease activity and symptom burdens in a patient with active ulcerative colitis: a case report
  33. Letter to the Editor
  34. Does the article titled “Hot arm and foot bath on heart rate variability and blood pressure in healthy volunteers – needs to be verified with standard device?” Have reporting bias?
  35. Abstracts
  36. 1st International Virtual Conference on Integrative Medicine 2021 (ICIM 2021) in conjunction with the 4th International Biohealth Science Conference
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