Home Medicine Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women
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Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women

  • Purwo Sri Rejeki EMAIL logo , Pradika Gita Baskara , Lilik Herawati , Adi Pranoto , Hayuris Kinandita Setiawan , Ronny Lesmana and Shariff Halim
Published/Copyright: March 15, 2022
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 33 Issue 6

Abstract

Objectives

Positive energy homeostasis due to overnutrition and a sedentary lifestyle triggers obesity. Obesity has a close relationship with elevated levels of betatrophin and may increase the risk of developing metabolic syndrome. Therefore, lifestyle modification through a nonpharmacological approach based on physical exercise is the right strategy in lowering betatrophin levels. This study aimed to analyze the effect of moderate-intensity interval and continuous exercises on decreased betatrophin levels and the association between betatrophin levels and obesity markers in women.

Methods

A total of 30 women aged 20–24 years old were randomly divided into three groups. Measurement of betatrophin levels using Enzyme-Linked Immunosorbent Assay (ELISA). Data analysis techniques used were one-way ANOVA and parametric linear correlation.

Results

The results showed that the average levels of betatrophin pre-exercise were 200.40 ± 11.03 pg/mL at CON, 203.07 ± 42.48 pg/mL at MIE, 196.62 ± 21.29 pg/mL at MCE, and p=0.978. Average levels of betatrophin post-exercise were 226.65 ± 18.96 pg/mL at CON, 109.31 ± 11.23 pg/mL at MIE, 52.38 ± 8.18 pg/mL at MCE, and p=0.000. Pre-exercise betatrophin levels were positively correlated with age, BMI, FM, WHR, FBG, and PBF (p≤0.001).

Conclusions

Our study showed that betatrophin levels are decreased by 10 min post-MIE and post-MCE. However, moderate-intensity continuous exercise is more effective in lowering betatrophin levels than moderate-intensity interval exercise. In addition, pre-exercise betatrophin levels also have a positive correlation with obesity markers.

Keywords: betatrophin; moderate-intensity exercise; myokine; obesity
Corresponding author: Purwo Sri Rejeki, Department of Medical Physiology and Biochemistry, Physiology Division, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, E-mail: , Phone: +62 821 4155 9388

Funding source: Fundamental Research Program of the Ministry of Research, Technology and Higher Education, Indonesia

Award Identifier / Grant number: 4/AMD/E1/KP.PTNBH/2020 and 580/UN3.14/PT/2020

Acknowledgments

We would like to express our gratitude to the Faculty of Sport Science, State University of Malang that has provided facilities in the screening process of a prospective research subject and the Fitness Center of Health Ministry of Malang that has provided facilities well. Also, we greatly appreciate and wish to thank Palang Merah Indonesia (PMI) Blood Transfusion Unit (UTD) of Malang that has assisted the blood sampling and blood centrifuge processes. This includes but is not limited to all parties of Physiology Laboratory, Faculty of Medicine, Universitas Brawijaya Malang who have helped the analysis process of betatrophin levels and all volunteers who have participated in this study.

  1. Research funding: This study is supported by the Fundamental Research Program of the Ministry of Research, Technology and Higher Education, Indonesia, under Grant Number: 4/AMD/E1/KP.PTNBH/2020 and 580/UN3.14/PT/2020.

  2. Author contribution: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: Based on the ethical standards of the Declaration of Helsinki 1975, this study has been approved by the Health Research Ethics Commission of the Faculty of Medicine, Universitas Airlangga, Surabaya with registration number: 309/EC/KEPK/FKUA/2019.

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Received: 2021-12-22
Revised: 2022-02-04
Accepted: 2022-02-15
Published Online: 2022-03-15

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2021-0393
Keywords for this article
betatrophin; moderate-intensity exercise; myokine; obesity

Articles in the same Issue

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  3. The effect of endurance, resistance training, and supplements on mitochondria and bioenergetics of muscle cells
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