The physiological insight of Coenzyme-Q10 administration in preventing the incidence of reperfusion arrhythmia among patients undergoing coronary artery bypass grafting surgery
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Louisa Fadjri Kusuma Wardhani
,
Ivana Purnama Dewi
,
Kresna Nugraha Setia Putra
,
Andrianto Andrianto
and
Djoko Soemantri
Abstract
Reperfusion arrhythmia following cardiac surgery has long been studied as part of myocardial damage. Reperfusion injury is thought to be exacerbated by oxygen-free radicals, whereas arrhythmogenic oscillations in membrane potential are mediated by reactive oxygen. Coenzyme Q10 is a lipid-soluble antioxidant that inhibits lipid peroxidation in biological membranes and supplies ATP cell synthesis, required as the organism’s primary energy source. This process explains how Coenzyme Q10 helps stabilize membranes and avoids critical metabolite depletion that may relate to reperfusion arrhythmia. There is a reduction of iatrogenic Coenzyme Q10 after coronary artery bypass surgery (CABG). On the other hand, there is an increased inflammatory process and cellular demand post CABG procedure. It leads to ischemia that can be manifested as arrhythmia. Reperfusion arrhythmia was less common in patients who took Coenzyme Q10. These findings suggest that Coenzyme Q10 supplementation might help patients with heart surgery avoid reperfusion arrhythmia. However, a higher-quality randomized controlled study is needed to determine the effect of Coenzyme Q10 in preventing reperfusion arrhythmia in cardiac surgery patients.
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Research funding: The authors report no involvement in the research by the sponsor that could have influenced the outcome of this work.
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Author contributions: LFKW dan IPD have given substantial contributions to the conception or the design of the manuscript and were a major contributor in writing the manuscript. IPD and KNSP editing the manuscript for publications. All authors have participated to drafting the manuscript, A and DS revised it critically. All authors read and approved the final version of the manuscript.
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Conflicts of interest: The authors certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.
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Consent for publication: Written informed consent was taken from the patient for the use of medical data for academic and research purposes including publication.
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Articles in the same Issue
- Frontmatter
- Minireview
- The effect of endurance, resistance training, and supplements on mitochondria and bioenergetics of muscle cells
- Reviews
- Cellular cross talk between epicardial fat and cardiovascular risk
- The physiological insight of Coenzyme-Q10 administration in preventing the incidence of reperfusion arrhythmia among patients undergoing coronary artery bypass grafting surgery
- Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data
- An overview of post COVID sequelae
- Clinical implications of anti-idiotype antibodies in COVID-19
- Original Articles
- Monocyte chemoattractant protein-1 levels are associated with major depressive disorder
- Detection of soluble suppression of tumorigenicity 2 and N-terminal B-type natriuretic peptide in a rat model of aortic regurgitation: differential responses to omecamtiv mecarbil
- Preoperative monocyte-to-lymphocyte ratio as a potential predictor of bladder cancer
- AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle
- Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women
- Impact of muscle mass on blood glucose level
- Behavioral alterations, brain oxidative stress, and elevated levels of corticosterone associated with a pressure injury model in male mice
- Patterns of drug therapy, glycemic control, and predictors of escalation – non-escalation of treatment among diabetes outpatients at a tertiary care center
- Pattern, severity, and outcome of adverse drug reactions in a tertiary care hospital: an evidence from a cross-sectional study
