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Behavioral alterations, brain oxidative stress, and elevated levels of corticosterone associated with a pressure injury model in male mice

  • Gabriel A. Aquino , Caren N. S. Sousa , Ingridy S. Medeiros , Jamily C. Almeida , Francisco M. S. Cysne Filho , Manuel A. Santos Júnior and Silvânia M. M. Vasconcelos
Published/Copyright: August 13, 2021
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 33 Issue 6

Abstract

Objectives

Sustained stress can cause physiological disruption in crucial systems like the endocrine, autonomic, and central nervous system. In general, skin damages are physical stress present in hospitalized patients. Also, these pressure injuries lead to pathophysiological mechanisms involved in the neurobiology of mood disorders. Here, we aimed to investigate the behavioral alterations, oxidative stress, and corticosterone levels in the brain areas of mice submitted to the model of pressure injury (PI).

Methods

The male mice behaviors were assessed in the open field test (OFT), elevated plus maze test (EPM), tail suspension test (TST), and sucrose preference test (SPT). Then, we isolated the prefrontal cortex (PFC), hippocampus (HP), and striatum (ST) by brain dissection. The nonprotein sulfhydryl groups (NP-SH) and malondialdehyde (MDA) were measured in the brain, and also the plasma corticosterone levels were verified.

Results

PI model decreased the locomotor activity of animals (p<0.05). Considering the EPM test, the PI group showed a decrease in the open arm activity (p<0.01), and an increase in the closed arm activity (p<0.05). PI group showed an increment in the immobility time (p<0.001), and reduced sucrose consumption (p<0.0001) compared to the control groups. Regarding the oxidative/nitrosative profile, all brain areas from the PI group exhibited a reduction in the NP-SH levels (p<0.0001–p<0.01), and an increase in the MDA level (p<0.001–p<0.01). Moreover, the PI male mice presented increased levels of plasma corticosterone (p<0.05).

Conclusions

Our findings suggest that the PI model induces depressive and anxiety-like behaviors. Furthermore, it induces pathophysiological mechanisms like the neurobiology of depression.

Keywords: animal models; behavior; depression; oxidative stress; pressure injury
Corresponding author: Silvânia M. M. Vasconcelos, Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brazil, Phone: +55 (85) 3366 8337, E-mail:

Funding source: CNPq

Funding source: CAPES

Acknowledgments

The authors deeply appreciate the invaluable contributions and support made by the Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Federal University of Ceará.

  1. Research funding: This original research was supported by the government agencies CNPq (National Coucil for Scientific and Technologic Development) and CAPES (National Coordination of High Education Personnel Formation Programs).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The experimental protocol was reviewed and approved by the Animal Research and Ethics Committee of the Faculty of Medicine of the Federal University of Ceará, under protocol number 93/17.

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Received: 2021-02-15
Accepted: 2021-07-17
Published Online: 2021-08-13

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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  2. Minireview
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  4. Reviews
  5. Cellular cross talk between epicardial fat and cardiovascular risk
  6. The physiological insight of Coenzyme-Q10 administration in preventing the incidence of reperfusion arrhythmia among patients undergoing coronary artery bypass grafting surgery
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  9. Clinical implications of anti-idiotype antibodies in COVID-19
  10. Original Articles
  11. Monocyte chemoattractant protein-1 levels are associated with major depressive disorder
  12. Detection of soluble suppression of tumorigenicity 2 and N-terminal B-type natriuretic peptide in a rat model of aortic regurgitation: differential responses to omecamtiv mecarbil
  13. Preoperative monocyte-to-lymphocyte ratio as a potential predictor of bladder cancer
  14. AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle
  15. Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women
  16. Impact of muscle mass on blood glucose level
  17. Behavioral alterations, brain oxidative stress, and elevated levels of corticosterone associated with a pressure injury model in male mice
  18. Patterns of drug therapy, glycemic control, and predictors of escalation – non-escalation of treatment among diabetes outpatients at a tertiary care center
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https://doi.org/10.1515/jbcpp-2021-0056
Keywords for this article
animal models; behavior; depression; oxidative stress; pressure injury

Articles in the same Issue

  1. Frontmatter
  2. Minireview
  3. The effect of endurance, resistance training, and supplements on mitochondria and bioenergetics of muscle cells
  4. Reviews
  5. Cellular cross talk between epicardial fat and cardiovascular risk
  6. The physiological insight of Coenzyme-Q10 administration in preventing the incidence of reperfusion arrhythmia among patients undergoing coronary artery bypass grafting surgery
  7. Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data
  8. An overview of post COVID sequelae
  9. Clinical implications of anti-idiotype antibodies in COVID-19
  10. Original Articles
  11. Monocyte chemoattractant protein-1 levels are associated with major depressive disorder
  12. Detection of soluble suppression of tumorigenicity 2 and N-terminal B-type natriuretic peptide in a rat model of aortic regurgitation: differential responses to omecamtiv mecarbil
  13. Preoperative monocyte-to-lymphocyte ratio as a potential predictor of bladder cancer
  14. AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle
  15. Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women
  16. Impact of muscle mass on blood glucose level
  17. Behavioral alterations, brain oxidative stress, and elevated levels of corticosterone associated with a pressure injury model in male mice
  18. Patterns of drug therapy, glycemic control, and predictors of escalation – non-escalation of treatment among diabetes outpatients at a tertiary care center
  19. Pattern, severity, and outcome of adverse drug reactions in a tertiary care hospital: an evidence from a cross-sectional study
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