Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial
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Zahra Azadbakht
Abstract
Objectives
The aim of this study was to recognize the efficacy and safety of curcumin ointment on patients with knee osteoarthritis (OA) compare to diclofenac as standard medication.
Methods
The topical effects of curcumin (10%) and diclofenac (1%) ointments were assessed through the visual analog scale (VAS) and Western Ontario and McMaster Universities Arthritis (WOMAC) index after three times a day administration for two weeks in 60 patients.
Results
Desirable effects compared to the pre-treatment period were observed after two weeks of continuous treatment. Based on our results, VAS and WOMAC index were altered after treatment significantly (p<0.0001).
Conclusions
Two-week use of curcumin ointment could ameliorate the pain, stiffness and function disability in patients with OA.
Funding source: Hamadan University of Medical Sciences
Award Identifier / Grant number: 9708295072
Acknowledgments
We would like to gratitude the participants in this study for their collaboration and we thank two teaching hospitals for their help in the evaluation and data handling.
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Research funding: This study was funded by Hamadan University of Medical Sciences (grant No: 9708295072).
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Author contribution: Serious revision of the manuscript, study idea and design, critical revision of the manuscript: Sara Ataei; comment of data, and designing of the manuscript: Mohammad Mahdi Mahboobian; data attainment: Zahra Azadbakht; analysis, interpretation of data, and statistical analysis: Mojdeh Mohammadi, study concept and design, supervised the entire processes: Firozeh Sajedi.
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Competing interests: The authors declare that they have no conflict of interest.
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Informed consent: Informed consent has been obtained from patients or their family members before entering the study.
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Ethical approval: The study was approved by the Ethics Committee of the Hamadan University of Medical Sciences (IR. UMSHA. REC.1396. 813). The study was in accordance with the 1975 Helsinki Declaration as revised in 2013.
References
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Peyronie’s disease: where are we at?
- Reviews
- Catheter-associated urinary tract infection: an overview
- Liver and heart failure: an ultrasound relationship
- Original Articles
- The intracellular fluid compartment is smaller than commonly believed when measured by whole-body bioimpedance
- Prevalence and distribution of causes of infertility according to women’s age – a cross-sectional study in a tertiary healthcare hospital setup
- Supplementation of antihypertensive drug regimen with vitamin E ameliorates alterations of primary haemodynamic parameters and total antioxidant capacity in ovariectomised rats
- Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial
- ProACT in the management of stress urinary incontinence after radical prostatectomy. What happens after 8 years of follow up? monocentric analysis in 42 patients
- The effect of metformin on the metabolism of human vascular smooth muscle cells in high glucose conditions
- Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s
- Effect of Om chanting and Yoga Nidra on depression anxiety stress, sleep quality and autonomic functions of hypertensive subjects – a randomized controlled trial
- Effectiveness of electrical vestibular nerve stimulation as adjunctive therapy to improve the cognitive functions in patients with Parkinson’s disease
- Role of interleukin-22 in tuberculosis patients
- Effect of aspirin on the TNF-α-mediated cell survival and death pathways in breast cancer
- Resting heart rate variability as a diagnostic marker of cardiovascular dysautonomia in postural tachycardia syndrome
- Effects of intensity and training on cardiovascular responses to the Valsalva maneouvre
Articles in the same Issue
- Frontmatter
- Editorial
- Peyronie’s disease: where are we at?
- Reviews
- Catheter-associated urinary tract infection: an overview
- Liver and heart failure: an ultrasound relationship
- Original Articles
- The intracellular fluid compartment is smaller than commonly believed when measured by whole-body bioimpedance
- Prevalence and distribution of causes of infertility according to women’s age – a cross-sectional study in a tertiary healthcare hospital setup
- Supplementation of antihypertensive drug regimen with vitamin E ameliorates alterations of primary haemodynamic parameters and total antioxidant capacity in ovariectomised rats
- Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial
- ProACT in the management of stress urinary incontinence after radical prostatectomy. What happens after 8 years of follow up? monocentric analysis in 42 patients
- The effect of metformin on the metabolism of human vascular smooth muscle cells in high glucose conditions
- Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s
- Effect of Om chanting and Yoga Nidra on depression anxiety stress, sleep quality and autonomic functions of hypertensive subjects – a randomized controlled trial
- Effectiveness of electrical vestibular nerve stimulation as adjunctive therapy to improve the cognitive functions in patients with Parkinson’s disease
- Role of interleukin-22 in tuberculosis patients
- Effect of aspirin on the TNF-α-mediated cell survival and death pathways in breast cancer
- Resting heart rate variability as a diagnostic marker of cardiovascular dysautonomia in postural tachycardia syndrome
- Effects of intensity and training on cardiovascular responses to the Valsalva maneouvre
