Role of interleukin-2 and interleukin-18 in newly diagnosed type 2 diabetes mellitus
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Smriti Suri
,
Prasenjit Mitra
,
Abhilasha Abhilasha
Abstract
Objectives
The study aimed to compare the levels of anti-inflammatory interleukin-2 (IL-2) and proinflammatory interleukin-18 (IL-18) among newly diagnosed type 2 diabetes mellitus (T2DM) and nondiabetic volunteers, to predict their roles as markers in the diagnosis of newly diagnosed T2DM.
Methods
In the study, 60 subjects were enrolled (30 T2DM cases and 30 non-diabetic controls). Biochemical parameters such as fasting plasma glucose (FBS), glycated haemoglobin (HbA1c), high sensitivity C-reactive protein (hs-CRP) and lipid profile were estimated in auto-analyser. Serum IL-2 and IL-18 levels were assessed by enzyme-linked immune sorbent assay (ELISA).
Results
Significant differences were observed in the levels of interleukins among study groups. The median (95% confidence interval) of IL-2 in cases and controls were 8.55 (6.07–47.23) and 45.87 (12.81–145.4) (p=0.02). The median (95% CI) of IL-18 on the other hand in cases and controls were 691.6 (580.3–872.6) and 511.1 (452.6–557.5) (p=0.0014).
Conclusions
Our study is the first to correlate IL-2 and IL-18 in newly diagnosed T2DM patients. Findings from this study highlight the anti-inflammatory role of IL-2 and proinflammatory role of IL-18 in T2DM. ROC analysis helped predict their role as markers in T2DM diagnosis.
Funding source: All India Institute of Medical Sciences, Jodhpur
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Research funding: The study was funded by All India Institute of Medical Sciences, Jodhpur, Rajasthan as a part of postgraduate dissertation work.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The ethical clearance was given by Institutional Ethics committee (IEC, AIIMS Jodhpur [Reference No. AIIMS/IEC/2018/742]).
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Articles in the same Issue
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- Traditional knowledge to clinical trials: a review on nutritional and therapeutic potential of Pithecellobium dulce
- Original Articles
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- Role of interleukin-2 and interleukin-18 in newly diagnosed type 2 diabetes mellitus
- Levels of lead, aluminum, and zinc in occupationally exposed workers of North-Western India
- Gonadotropin levels reduced in seven days immobilization stress-induced depressive-like behavior in female rats
- Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on pulmonary function in hypertensive patients
- Carvedilol improves heart rate variability indices, biomarkers but not cardiac nerve density in streptozotocin-induced T2DM model of diabetic cardiac autonomic neuropathy
Articles in the same Issue
- Frontmatter
- Reviews
- Use of cannabinoids for the treatment of patients with post-traumatic stress disorder
- Traditional knowledge to clinical trials: a review on nutritional and therapeutic potential of Pithecellobium dulce
- Original Articles
- Protective role of protocatechuic acid in carbon tetrachloride-induced oxidative stress via modulation of proinflammatory cytokines levels in brain and liver of Wistar rats
- Association of glycaemic status and outcomes in diabetic foot problems: a retrospective evidence from South India
- Piperine protects oxidative modifications in human erythrocytes
- Effects of Artemisia supplementation on anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial
- A tablet derived from Andrographis paniculata complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice
- Role of interleukin-2 and interleukin-18 in newly diagnosed type 2 diabetes mellitus
- Levels of lead, aluminum, and zinc in occupationally exposed workers of North-Western India
- Gonadotropin levels reduced in seven days immobilization stress-induced depressive-like behavior in female rats
- Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on pulmonary function in hypertensive patients
- Carvedilol improves heart rate variability indices, biomarkers but not cardiac nerve density in streptozotocin-induced T2DM model of diabetic cardiac autonomic neuropathy
