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Gonadotropin levels reduced in seven days immobilization stress-induced depressive-like behavior in female rats

  • Zafer Sahin , Alpaslan Ozkurkculer , Omer Faruk Kalkan , Funda Gulcu Bulmus , Ozgur Bulmus and Selim Kutlu
Published/Copyright: February 10, 2021
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 33 Issue 2

Abstract

Objectives

Reproduction is one of the physiological functions that are often negatively affected by chronic stress. We aimed to examine effects of two distinct 7-day chronic immobilization stress (IMO) models on gonadotropins levels and depression-like behaviors in female rats.

Methods

Adult Wistar albino female rats were divided into three groups as follows (n=7 for each group): control, IMO-1 (45 min daily for 7-day) and IMO-2 (45 min twice a day for 7-day). Neuropsychiatric behaviors were determined by using forced swimming test (FST) and open field test (OFT). Gonadotropins were analyzed using ELISA tests.

Results

In FST, swimming was lower, and immobility was higher in the IMO-1 group and IMO--2 group. Climbing score of the IMO-2 group was higher compared to the control group. In OFT, there was no significant alteration in the mean velocity, total distance, duration of time spent in the central area and duration of latency in the central area between the stress groups and the control group. Final body weight and percentage of body weight change were lower in both stress groups. The follicle-stimulating hormone level was lower only in the IMO-2 group, and the luteinizing hormone concentrations were significantly lower in the IMO-1 group and IMO-2 group.

Conclusions

Our results indicated that depression-like behaviors increased, and gonadotropins decreased in the female rats exposed to 7-day chronic IMO.

Keywords: depression; female; FSH; gonadotropin; immobilization stress; LH; rat
Corresponding author: Zafer Sahin, PhD, Department of Physiology, Karadeniz Technical University, Medical School, Trabzon, 61080, Turkey, Phone: +904623777755, Fax: +90 462 325 32 05, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: All experimental protocols were approved by the Local Ethics Committee of Necmettin Erbakan University (Konya, Turkey, Permission no: 2020-003), and the animals were treated in accordance with the national and international laws and policies on the care and use of experimental animals.

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Received: 2020-07-13
Accepted: 2020-11-22
Published Online: 2021-02-10

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2020-0195
Keywords for this article
depression; female; FSH; gonadotropin; immobilization stress; LH; rat

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Use of cannabinoids for the treatment of patients with post-traumatic stress disorder
  4. Traditional knowledge to clinical trials: a review on nutritional and therapeutic potential of Pithecellobium dulce
  5. Original Articles
  6. Protective role of protocatechuic acid in carbon tetrachloride-induced oxidative stress via modulation of proinflammatory cytokines levels in brain and liver of Wistar rats
  7. Association of glycaemic status and outcomes in diabetic foot problems: a retrospective evidence from South India
  8. Piperine protects oxidative modifications in human erythrocytes
  9. Effects of Artemisia supplementation on anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial
  10. A tablet derived from Andrographis paniculata complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice
  11. Role of interleukin-2 and interleukin-18 in newly diagnosed type 2 diabetes mellitus
  12. Levels of lead, aluminum, and zinc in occupationally exposed workers of North-Western India
  13. Gonadotropin levels reduced in seven days immobilization stress-induced depressive-like behavior in female rats
  14. Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on pulmonary function in hypertensive patients
  15. Carvedilol improves heart rate variability indices, biomarkers but not cardiac nerve density in streptozotocin-induced T2DM model of diabetic cardiac autonomic neuropathy
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