Traditional knowledge to clinical trials: a review on nutritional and therapeutic potential of Pithecellobium dulce

Suresh Sulekha Dhanisha; Sudarsanan Drishya; Chandrasekharan Guruvayoorappan

doi:10.1515/jbcpp-2020-0166

Article

Traditional knowledge to clinical trials: a review on nutritional and therapeutic potential of Pithecellobium dulce

Suresh Sulekha Dhanisha , Sudarsanan Drishya and Chandrasekharan Guruvayoorappan

Published/Copyright: February 9, 2021

Published by

Become an author with De Gruyter Brill

Submit Manuscript Author Information Explore this Subject

From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 33 Issue 2

Abstract

The review describes botanical aspects, bioactive phytocompounds and pharmacological properties of different parts of Pithecellobium dulce, with special emphasis on the nutritional status of its fruits. The different parts of plant extract have been reported to possess anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, cardio protective, anti-diarrhoeal, anti-ulcerogenic, larvicidal and ovicidal activities. Different parts of plant extracts were reported to contain several bioactive phytocompounds such as flavonoids, saponins, tannins, alkaloids etc. Natural products discovered so far served as a viable source for new drugs. Over the past few years, continued and perpetual attention of people has been paid to medicinal plants in connection with its remarkable importance in drug discovery. Plant products always remains a drug of choice for the identification of novel leads despite facing a tough competition from existing synthetic alternatives derived from combinatorial chemistry, owing to their efficacy, side effects, and safety. P. dulce is a highly acclaimed genus in traditional system of medicine because of its versatile nutraceutical and pharmacological properties. In this review we discuss in detail about nutritional and various therapeutic properties of P. dulce.

Keywords: botanical identification; nutrition; pharmacological properties; traditional medicine

Corresponding author: Dr. Chandrasekharan Guruvayoorappan, Assistant Professor, Laboratory of Immunopharmacology and Experimental Therapeutics, Division of Cancer Research, Regional Cancer Centre, Medical College Campus, University of Kerala, Thiruvananthapuram, Kerala 695 011, India, Phone: +0471 2522337, +919894337418, E-mail: gururcctvm@gmail.com

Funding source: University Grants Commission

Award Identifier / Grant number: 20/12/2015(ii)EU-V

Funding source: Council of Scientific and Industrial Research

Award Identifier / Grant number: 09/553(0022)/2016-EMR-1

Acknowledgment

The authors acknowledge University Grants Commission (UGC) and Council of Scientific and Industrial Research (CSIR) for providing support in the form of junior research fellowship for the study. The authors are thankful to Dr. Rekha A Nair, Director, Regional Cancer Centre (RCC) and Dr. S. Kannan, Head, Division of Cancer Research, RCC, for providing valuable support required for the study.

Research funding: CSIR (Grants No: 09/553(0022)/2016-EMR-1) and UGC (Grant No: 20/12/2015(ii)EU-V) are providing Fellowship for PhD studies.
Author contributions: Dhanisha Suresh Sulekha prepared the review. Drishya Sudarshanan assisted in data collection and preparation of the review. Dr. Guruvayoorappan C. coordinated the preparation of review.
Competing interests: Authors state no conflict of interest.
Informed consent: Not applicable.
Ethical approval: Not applicable.

References

1. Butler, MS. Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep 2008;25:475–516. https://doi.org/10.1039/b514294f.Search in Google Scholar PubMed

2. Ngo, LT, Okogun, JI, Folk, WR. 21st Century natural product research and drug development and traditional medicines. Nat Prod Rep 2013;30:584–92. https://doi.org/10.1039/c3np20120a.Search in Google Scholar PubMed PubMed Central

3. Fabricant, DS, Farnsworth, NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 2001;109:69–75. https://doi.org/10.1289/ehp.01109s169.Search in Google Scholar PubMed PubMed Central

4. Ryan, A. Treating the health care crisis: complementary and Alternative medicine for PPACA. De Paul J HealthC 2012;14:35–98.Search in Google Scholar

5. Galm, U, Shen, B. Natural product drug discovery: the times have never been better. Chem Biol 2007;14:1098–104. https://doi.org/10.1016/j.chembiol.2007.10.004.Search in Google Scholar PubMed

6. Holmes, FA, Walters, RS, Theriault, RL, Forman, AD, Newton, LK, Raber, MN, et al.. Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J Natl Cancer Inst 1991;83:1797–805. https://doi.org/10.1093/jnci/83.24.1797-a.Search in Google Scholar PubMed

7. Shi, QW, Li, LG, Huo, CH, Zhang, ML, Wang, YF. Study on natural medicinal chemistry and new drug development. Chin Tradit Herb Drugs 2010;41:1583–9.Search in Google Scholar

8. Wani, MC, Horwitz, SB. Nature as a remarkable chemist: a personal story of the discovery and development of Taxol. Anti-Cancer Drug 2014;25:482–7. https://doi.org/10.1097/cad.0000000000000063.Search in Google Scholar PubMed PubMed Central

9. James, D, Wain, KK. Medicinal plants of the world. Computer index with more than 85,000 entries; 1981:103–4 pp.Search in Google Scholar

10. Preethi, S, Saral, MA. GC-MS analysis of microwave assisted ethanolic extract of Pithecellobiumdulce. Malaya J Biosci 2014;1:242–7.Search in Google Scholar

11. Mule, VS, Naikwade, NS, Magdum, C, Jagtap, VA. Antidiabetic activity of extracts of Pithecellobiumdulcebenth leaves in alloxan induced diabetic rats. Int J Pharmaceut Sci Drug Res 2016;8:275–80. https://doi.org/10.25004/ijpsdr.2016.080507.Search in Google Scholar

12. Kalavani, R, Banu, RS, Jeyanthi, KA, Sankari, TU, Kanna, AV. Evaluation of anti-inflammatory and antibacterial activity of Pithecellobiumdulce (Benth) extract. Biotechnol Res 2016;2:148–54.Search in Google Scholar

13. Katekhaye, SD, Kale, MS. Antioxidant and free radical scavenging activity of Pithecellobiumdulce (Roxb.) Benth wood bark and leaves. Free Radic Antioxid 2012:47–57. https://doi.org/10.5530/ax.2012.3.7.Search in Google Scholar

14. Shanmugakumar, SD, Amerjothy, S, Balakrishna, K. Pharmacognostical, antibacterial and antifungal potentials of the leaf extracts of Pithecellobium dulce Benth. Phcog Mag 2006;2:163–7.Search in Google Scholar

15. Sugumaran, M, Vetrichelvan, T, Quine, SD. Locomotor activity of leaf extracts of Pithecellobium dulce Benth. Ethnobot Leaflets 2008;12:490–3.Search in Google Scholar

16. Kumar, M, Nehra, K, Duhan, JS. Phytochemical analysis and antimicrobial efficacy of leaf extracts of Pithecellobium dulce. Asian J Pharmaceut Clin Res 2013;6:70–6.Search in Google Scholar

17. Selvan, SA, Muthukumaran, P. Analgesic and anti-inflammatory activities of leaf extract of Pithecellobium dulce Benth. Int J Pharmtech Res 2011;3:337–41.Search in Google Scholar

18. Katekhaye, SD, Nagmoti, DN. α-Glucosidase and α-amylase inhibition activities of Pithecellobium dulce bark and leaves. Phytopharmacology 2013;4:123–30.Search in Google Scholar

19. Govindarajan, M, Rajeswary, M, Sivakumar, R. Larvicidal and ovicidal efficacy of Pithecellobiumdulce(Roxb.) Benth. (Fabaceae) against Anopheles stephensi Liston &Aedesaegypti Linn. (Diptera: Cuclicidae). Indian J Med Res 2013;138:129–34.Search in Google Scholar

20. Sugumaran, M, Vetrichelvan, T, Darlin Quine, S. In vitro anthelmintic activity of leaf extracts of Pithecellobium dulce benth. Asian J Microbiol Biotechnol Environ Sci Paper 2010;12:313–4.Search in Google Scholar

21. Sundarrajan, T, Raj kumar, T, Udhayakumar, E, Arunachalam, G. Hypolipidemic activity of Pithecellobium dulce Bench. in Triton Wr-1339 induced hyperlipidemic rats. Int J Chem Pharmaceut Sci 2010;1:50–3.Search in Google Scholar

22. Mule, VS, Potdar, VH, Disouza, JI. Neuropharmacological profile of aqueous and ethanolic extract of Pithecellobum dulce Benth leaves in mice. Res J Pharmacol Pharmacodyn 2011;3:27–30.Search in Google Scholar

23. Dhanisha, SS, Drishya, S, Guruvayoorappan, C. Pithecellobium dulce fruit extract mitigates cyclophosphamide mediated toxicity by regulating proinflammatory cytokines. J Food Biochem 2020;44;1:e13083. https://doi.org/10.1111/jfbc.13083.Search in Google Scholar PubMed

24. Pradeepa, S, Subramanian, S, Kaviyarasan, V. Biochemical evaluation of antidiabetic properties of Pithecellobium dulce fruits studied in streptozotocin induced experimental diabetic rats. Int J Herb Med 2013;1:21–8.Search in Google Scholar

25. Sukantha, TA, Subashini, KS, Ravindran, NT, Balashanmugam, P. Evaluation of in vitro antioxidant and antibacterial activity of Pithecellobium dulce Benth fruit peel. Int J Curr Res 2011;3:378–82.Search in Google Scholar

26. Megala, J, Geetha, A. Effect of Pithecellobiumdulce (Roxb.) Benth. fruit extract on cysteamine induced duodenal ulcer in rats. Indian J Exp Biol 2015;53:657–64.Search in Google Scholar

27. Bhargvakrishna, P, Gupta, MB, Mitra, CR, Chittranjan, R. Anti-inflammatory activity of saponins and other natural products. Indian J Med Res 1970;58:724–30.Search in Google Scholar

28. Pal, PB, Pal, S, Manna, P, Sil, PC. Traditional extract of Pithecellobium dulce fruits protects mice against CCl4 induced renal oxidative impairments and necrotic cell death. Pathophysiology 2012;19:101–14. https://doi.org/10.1016/j.pathophys.2012.02.001.Search in Google Scholar PubMed

29. Thangarajan, P, Anumanthan, A, Venkatachalam, U, Sivakumar, S, Somaskandan, C. Cardioprotective activity of Pithecellobiumdulce fruit peel on isoproterenol-induced myocardial infarction in rats. Int J Pharmaceut Sci Rev Res 2015;30:133–6.Search in Google Scholar

30. Nigam, SK, Gopal, M, Uddin, R, Yoshikawa, K, Kawamoto, M, Arihara, S. Pithedulosides A-G, oleanane glycosides from Pithecellobium dulce. Phytochemistry 1997;44:1329–34. https://doi.org/10.1016/s0031-9422(96)00725-x.Search in Google Scholar

31. Palanivel, Agarwal, SK, Manjulvani, SK, Karthikeyan, V, Periyasamy, P, Sivakumar, GM. Evaluation of anti-ulcer activity of Pithecellobium dulce (seeds) in rats using pylorus ligation. World J Pharm Pharmaceut Sci 2014;3:2175–84.Search in Google Scholar

32. Barrera-Necha, L, Bautista-Baños, S, Bravo-Luna, L, Bermudez-Torres, K, Jimenez-Estrada, M, Reyes-Chilpa, R, et al.. Antifungal activity against postharvest fungi by extracts and compounds of Pithecellobium dulce seeds (Huamuchil). Acta Hortic 2003;628:761–6. https://doi.org/10.17660/actahortic.2003.628.96.Search in Google Scholar

33. Pithayanukul, P, Ruenraroengsak, P, Bavovada, R, Pakmanee, N, Suttisri, R, Saen-oon, S. Inhibition of Najakaouthia venom activities by plant polyphenols. J Ethnopharmacol 2005;97:527–33. https://doi.org/10.1016/j.jep.2004.12.013.Search in Google Scholar

34. Nagmoti, DM, Kothavade, PS, Bulani, VD, Gawali, NB, Juvekar, AR. Antidiabetic and antihyperlipidemic activity of Pithecellobiumdulce (Roxb.) Benth seeds extract in streptozotocin-induced diabetic rats. Eur J Integr Med 2015;7:263–73. https://doi.org/10.1016/j.eujim.2015.01.001.Search in Google Scholar

35. Nagmoti, DM, Khatri, DK, Juvekar, PR, Juvekar, AR. Antioxidant activity free radical-scavenging potential of PithecellobiumdulceBenth seed extracts. Free Radic Antioxid 2012;2:37–43. https://doi.org/10.5530/ax.2012.2.2.7.Search in Google Scholar

36. Praveen, AR, Prasanth, KH, Venkatesh, P, Kalyan, BV, Babu, IS. Antidiabetic activity of bark extract of Pithecellobium dulce benth in alloxan-induced diabetic rats. Nat Prod 2010;6:201–4.Search in Google Scholar

37. Yadava, RN, Chakravarty, A. In vitro anti-inflammatory activity of new allelochemical from the bark of Pithecellobiumdulce (Roxb.) Benth. Indian J Chem;56B:447–52.Search in Google Scholar

38. Singh, RL, Shukla, M. Oxidative DNA damage protective activity and antioxidant and hepatoprotective potentials of Pithecellobium dulce. Plant J Nutr Food Sci 2013;3:205–10.Search in Google Scholar

39. Libby, P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev 2007;65:S140–6. https://doi.org/10.1301/nr.2007.dec.s140-s146.Search in Google Scholar

40. Sugumaran, M, Vetrichelvan, T, Darlin, QS. Anti-inflammatory activity of folklore: Pithecellobium dulce Benth. Res J Pharm Technol 2009;2:868–9.Search in Google Scholar

41. Sahu, NP, Mahato, SB. Anti-inflammatory triterpene saponins of Pithecellobium dulce: Characterization of an echinocystic acid bisdesmoside. Phytochemistry 1994;37:1425–7. https://doi.org/10.1016/s0031-9422(00)90425-4.Search in Google Scholar

42. Pradeepa, S, Subramanian, S, Kaviyarasan, V. Evaluation of antimicrobial activity of Pithecellobium dulce pod pulp extract. Asian J Pharmaceut Clin Res 2014;7:32–7.Search in Google Scholar

43. Lakshmi, YS, Mala, D, Gopalakrishnan, S, Banu, F, Brindha, V. Antimicrobial activity of silver nanoparticles from Pithecellobiumdulce. Indian J. Nano Sci 2014;2:1–3.Search in Google Scholar

44. Kumari, S. Evaluation of phytochemical analysis and antioxidant and antifungal activity of Pithecellobium dulce leaves’ extract. Asian J Pharmaceut Clin Res 2016;10:370. https://doi.org/10.22159/ajpcr.2017.v10i1.15576.Search in Google Scholar

45. Sawasdipuksa, N, Lei, Z, Sumner, LW, Niyomploy, P, Sangvanich, P. A lysozyme with antifungal activity from P. dulce seeds. Food Technol Biotechnol 2011;49:489–94.Search in Google Scholar

46. Manna, P, Bhattacharyya, S, Das, J, Ghosh, J, Sil, PC. Phytomedicinal role of Pithecellobiumdulce against CCl4-mediated hepatic oxidative impairments and necrotic cell death. Evid Based Complement Altern Med 2011:832805.10.1093/ecam/neq065Search in Google Scholar PubMed PubMed Central

47. Bagchi, S, Kumar, KJ. Studies on water soluble polysaccharides from Pithecellobiumdulce (Roxb.) Benth seeds. Carbohydr Polym 2016;138:215–21. https://doi.org/10.1016/j.carbpol.2015.11.018.Search in Google Scholar PubMed

48. Bhavani, R, Shobana, R, Rajeshkumar, S. Cardioprotective activity of Pithecellobium dulce flower and fruit aqueous extracts. Int J Pharmacol Res 2014;6:82–9.Search in Google Scholar

49. Katekhaye, SD, Kale, MS. Antioxidant and free radical scavenging activity of Pithecellobium dulce Benth wood bark and leaves. Free Radic Antioxid 2012;2:47–57. https://doi.org/10.5530/ax.2012.3.7.Search in Google Scholar

50. Kumari, S. Evaluation of phytochemical analysis, antioxidant and antifungal activity of Pithecellobium dulce leaves extract. Asian J Pharmaceut Clin Res 2016;10:370. https://doi.org/10.22159/ajpcr.2017.v10i1.15576.Search in Google Scholar

51. Venu, C, Ramanjaneyulu, K, Satish Reddy, N, Vijayalaxmi, B, Bhavana, A. Evaluation of antidiarrhoeal activity of ethanolic extracts of Pithecellobium dulce on castor oil induced diarrhoea in albino Wistar rats. Discovery 2016;52:1494–6.Search in Google Scholar

52. Megala, J, Devaraju, P. Anti-ulcerogenic effect of P. dulce by influencing gastric gene. J Young Pharm 2015;7:493–9. https://doi.org/10.5530/jyp.2015.4s.12.Search in Google Scholar

53. Megala, J, Devaraju, P. Pithecellobiumdulce fruit extract exerts antiulcerogenic effect by influencing the gastric expression of H+, K+-ATPase and mucosal glycoproteins. J Young Pharm 2015b;7:493–9. https://doi.org/10.5530/jyp.2015.4s.12.Search in Google Scholar

54. Marimuthu, G, Mohan, R. Mosquito larvicidal and ovicidal properties of Pithecellobiumdulce (Roxb.) Benth. (Fabaceae) against Culexquinquefasciatus Say (Diptera: Culicidae). J. Coast Life Med 2014;2:308–12.Search in Google Scholar

55. Ponmozhi, P, Geetha, M, Kumar, SM, Devi, SP. Extraction of anthocyanin and analysing its antioxidant properties from Pithecellobium dulce fruit pericarp. Asian J Pharmaceut Clin Res 2011;4:41–5.Search in Google Scholar

56. Singhal, M. Physiochemical investigation of seed of plant Pithecellobium dulce. Galaxy Int Interdiscip Res J 2014;2:205–7.Search in Google Scholar

57. Selvakumar, M, Dinesh Kumar, L, Velusamy, A, Ronaldo Anuf, A. Nutritional and therapeutic benefits of medicinal plant Pithecellobium dulce (Fabaceae): a review. J Appl Pharmaceut Sci 2019;9:130–9.10.7324/JAPS.2019.90718Search in Google Scholar

Received: 2020-06-23

Accepted: 2020-11-22

Published Online: 2021-02-09

You are currently not able to access this content.

Articles in the same Issue

https://doi.org/10.1515/jbcpp-2020-0166

Keywords for this article

botanical identification; nutrition; pharmacological properties; traditional medicine