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Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio

  • Oktay Bulur ORCID logo EMAIL logo , Doğan Öztürk ORCID logo , Derun Taner Ertuğrul ORCID logo , Selim Sayın ORCID logo , Zeliha Asiltürk ORCID logo , Kürşat Dal ORCID logo , Mutlu Şahin ORCID logo , Hakan Buluş ORCID logo und Metin Uzman ORCID logo
Veröffentlicht/Copyright: 5. Juli 2021
Journal of Basic and Clinical Physiology and Pharmacology
Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 33 Heft 4

Abstract

Objectives

Obesity and related diseases have become one of the most important health problems in the modern age. In addition to its clinical use in the treatment of obesity, bariatric surgery reduces obesity-induced inflammation. Neutrophil–lymphocyte ratio (NLR) is a cheap and easily attainable inflammatory marker. The purpose of this study is to show the effect of bariatric surgery on NLR at preoperative and postoperative 3rd, 6th, and 12th months after SG.

Methods

298 patients, who underwent sleeve gastrectomy (SG) in general surgery clinic between 2015 and 2017, were included in the study. We excluded the patients younger than 18 years old, and did not have any inflammatory, infectious, hematological, and comorbide diseases such as diabetes mellitus, cardiovascular diseases, ischemic heart disease, hypertension, renal insufficiency, cancer, and respiratory problems like asthma, obstructive sleep apnea syndrome. We evaluated the levels of NLR at preoperative and postoperative 3rd, 6th, and 12th months visits.

Results

There were a total of 298 adult patients (age: mean 38.6, minimum 18, maximum 69 years old). Of whom 247 were female (82.9%) and 51 were male (17.1%). We found that NLR levels decreased significantly at 3rd, 6th, and 12th month visits after SG (p<0.001).

Conclusions

We concluded that NLR levels decrease after surgery in a proportional reduction in adipose tissue. The decrease in NLR levels may also be associated with the protective effects of sleeve gastrectomy against low-grade inflammation-related diseases.

Keywords: neutrophil–lymphocyte ratio; obesity; sleeve gastrectomy
Corresponding author: Oktay Bulur, MD, Department of Internal Medicine, Health Sciences University Turkey, Kecioren Training and Research Hospital, Pınarbaşı Mah. Sanatoryum Cad. Ardahan Sok. No: 25, 06380, Kecioren, Ankara, Turkey, Phone: +90 312 3569000, Fax: +90 312 2213276, E-mail:

  1. Research funding: There is no funding in this study from any person, institute or company.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors declare that they have no competing interests.

  4. Informed consent: This manuscript does not contain any individual person’s data in any form (including any individual details, images or videos).

  5. Ethics approval: This research conducted in according to the Declaration of Helsinki, and was accepted by Health Sciences University Keçiören Teaching and Research Hospital ethics committee (Number: 032019/1871, date: 13.03.2019).

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jbcpp-2020-0179).

Received: 2020-06-30
Accepted: 2021-03-18
Published Online: 2021-07-05

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Minireview
  3. Can pulse wave velocity (PWV) alone express arterial stiffness? A neglected tool for vascular function assessment
  4. Review
  5. Hyponatremia in heart failure: not just 135 to 145
  6. Original Articles
  7. Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
  8. Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats
  9. Terminalia arjuna supplementation ameliorates high fat diet-induced oxidative stress in nephrotoxic rats
  10. Decreased expression of annexin A2 and loss of its association with vascular endothelial growth factor leads to the deficient trophoblastic invasion in preeclampsia
  11. Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models
  12. Assessment of sleep quality and its predictors among newly diagnosed psychiatric patients
  13. Ovalbumin/lipopolysaccharide induced vasculitis in rats: a new predictive model
  14. Dose-dependent and time-dependent metabolic, hemodynamic, and redox disturbances in dexamethasone-treated Wistar rats
  15. Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio
  16. Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-κB in rats subjected to experimental pancreatitis – influence of HSP70
  17. Effects of Onosma dichroanthum Boiss. root extract on AGS human gastric cancer cell-line
  18. Feasibility, face, and content validity of quantitative computed tomography in interstitial lung disease related to connective tissue diseases
  19. In vitro anticoagulant activity of selected medicinal plants: potential interactions with warfarin and development of new anticoagulants
  20. Normal reference value of orthodromic and antidromic sensory nerve conduction velocity of median nerve with intact palmaris longus tendon in apparently healthy individuals
  21. Short Communication
  22. Chemokine receptor antagonists with α1-adrenergic receptor blocker activity
https://doi.org/10.1515/jbcpp-2020-0179
Schlagwörter für diesen Artikel
neutrophil–lymphocyte ratio; obesity; sleeve gastrectomy

Artikel in diesem Heft

  1. Frontmatter
  2. Minireview
  3. Can pulse wave velocity (PWV) alone express arterial stiffness? A neglected tool for vascular function assessment
  4. Review
  5. Hyponatremia in heart failure: not just 135 to 145
  6. Original Articles
  7. Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
  8. Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats
  9. Terminalia arjuna supplementation ameliorates high fat diet-induced oxidative stress in nephrotoxic rats
  10. Decreased expression of annexin A2 and loss of its association with vascular endothelial growth factor leads to the deficient trophoblastic invasion in preeclampsia
  11. Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models
  12. Assessment of sleep quality and its predictors among newly diagnosed psychiatric patients
  13. Ovalbumin/lipopolysaccharide induced vasculitis in rats: a new predictive model
  14. Dose-dependent and time-dependent metabolic, hemodynamic, and redox disturbances in dexamethasone-treated Wistar rats
  15. Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio
  16. Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-κB in rats subjected to experimental pancreatitis – influence of HSP70
  17. Effects of Onosma dichroanthum Boiss. root extract on AGS human gastric cancer cell-line
  18. Feasibility, face, and content validity of quantitative computed tomography in interstitial lung disease related to connective tissue diseases
  19. In vitro anticoagulant activity of selected medicinal plants: potential interactions with warfarin and development of new anticoagulants
  20. Normal reference value of orthodromic and antidromic sensory nerve conduction velocity of median nerve with intact palmaris longus tendon in apparently healthy individuals
  21. Short Communication
  22. Chemokine receptor antagonists with α1-adrenergic receptor blocker activity
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