Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models
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Ravindran Revand
Abstract
Objectives
The present work was designed to study the modulatory effects of algogen-induced vasosensory reflex responses on short-term heart rate variability (HRV) parameters in naïve and vagotomized rat models.
Methods
In this study, vasosensory reflex responses were elicited by instilling algogens (bradykinin/histamine), a component of inflammatory mediators into a local segment of medium-sized peripheral blood vessel (femoral artery) while a continuous electrocardiogram (ECG) was recorded. Short-term (5 min) ECG segments obtained from original recordings were examined in detail and relevant data of HRV parameters were pooled. Time domain and frequency domain analyses were performed using dedicated software (LabChart 8, AD Instruments®, Australia) and results were analyzed.
Results
Bradykinin-induced vasosensory reflexes caused significant alterations in both time domain and frequency domain HRV parameters as compared to the time-matched saline control group. Instillation of bradykinin caused a transient increase in NN interval, RMSSD, TSP, HF power (HFP) along with a decrease in the standard deviation of all normal NN intervals (SDNN), SDNN/RMSSD, LF power (LFP), LFP/HFP. Histamine produced a similar pattern of responses, but HRV alterations were less pronounced compared to those with bradykinin. Further analysis revealed that algogen-induced vasosensory reflex responses caused an increase in the parasympathetic influence on the heart accompanied by a decrease in sympathetic influence. In addition, HRV modulation by algogen-induced vasosensory reflexes was significantly attenuated in vagotomized rats, illustrating the principal role of vagus in the reflex HRV modulation.
Conclusions
The present study proposes a novel hypothesis regarding the cardio-protective role of inflammatory mediators during acute stress, by potentiating the vagal impact and attenuating the sympathetic impact on the heart.
Acknowledgments
The authors convey their deep sense of gratitude to the Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India, for providing an excellent platform to conduct this study.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable as no human subjects are involved in the study.
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Ethical approval: The research related to animal use has complied with all the relevant national regulations (CPCSEA) and those issued by the Institutional Animal Ethics Committee (Ref. No. Dean/2019/IAEC/1627 dated 17.11.2019).
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Minireview
- Can pulse wave velocity (PWV) alone express arterial stiffness? A neglected tool for vascular function assessment
- Review
- Hyponatremia in heart failure: not just 135 to 145
- Original Articles
- Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
- Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats
- Terminalia arjuna supplementation ameliorates high fat diet-induced oxidative stress in nephrotoxic rats
- Decreased expression of annexin A2 and loss of its association with vascular endothelial growth factor leads to the deficient trophoblastic invasion in preeclampsia
- Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models
- Assessment of sleep quality and its predictors among newly diagnosed psychiatric patients
- Ovalbumin/lipopolysaccharide induced vasculitis in rats: a new predictive model
- Dose-dependent and time-dependent metabolic, hemodynamic, and redox disturbances in dexamethasone-treated Wistar rats
- Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio
- Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-κB in rats subjected to experimental pancreatitis – influence of HSP70
- Effects of Onosma dichroanthum Boiss. root extract on AGS human gastric cancer cell-line
- Feasibility, face, and content validity of quantitative computed tomography in interstitial lung disease related to connective tissue diseases
- In vitro anticoagulant activity of selected medicinal plants: potential interactions with warfarin and development of new anticoagulants
- Normal reference value of orthodromic and antidromic sensory nerve conduction velocity of median nerve with intact palmaris longus tendon in apparently healthy individuals
- Short Communication
- Chemokine receptor antagonists with α1-adrenergic receptor blocker activity
Articles in the same Issue
- Frontmatter
- Minireview
- Can pulse wave velocity (PWV) alone express arterial stiffness? A neglected tool for vascular function assessment
- Review
- Hyponatremia in heart failure: not just 135 to 145
- Original Articles
- Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
- Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats
- Terminalia arjuna supplementation ameliorates high fat diet-induced oxidative stress in nephrotoxic rats
- Decreased expression of annexin A2 and loss of its association with vascular endothelial growth factor leads to the deficient trophoblastic invasion in preeclampsia
- Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models
- Assessment of sleep quality and its predictors among newly diagnosed psychiatric patients
- Ovalbumin/lipopolysaccharide induced vasculitis in rats: a new predictive model
- Dose-dependent and time-dependent metabolic, hemodynamic, and redox disturbances in dexamethasone-treated Wistar rats
- Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio
- Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-κB in rats subjected to experimental pancreatitis – influence of HSP70
- Effects of Onosma dichroanthum Boiss. root extract on AGS human gastric cancer cell-line
- Feasibility, face, and content validity of quantitative computed tomography in interstitial lung disease related to connective tissue diseases
- In vitro anticoagulant activity of selected medicinal plants: potential interactions with warfarin and development of new anticoagulants
- Normal reference value of orthodromic and antidromic sensory nerve conduction velocity of median nerve with intact palmaris longus tendon in apparently healthy individuals
- Short Communication
- Chemokine receptor antagonists with α1-adrenergic receptor blocker activity
