Startseite Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
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Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats

  • Stephen A. Adefegha , Felix A. Dada ORCID logo EMAIL logo , Sunday I. Oyeleye und Ganiyu Oboh
Veröffentlicht/Copyright: 16. März 2021
Journal of Basic and Clinical Physiology and Pharmacology
Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 33 Heft 4

Abstract

Objectives

Several studies had been conducted to examine the link between diabetes and diabetes encephalopathy. This study was conducted to examine the potency of berberine (BER) on the restoration of impaired neurochemicals in the brain of streptozotocin (STZ)-induced diabetic Wistar rats.

Methods

Fifty-six (56) adult rats weighing between 200 and 230 g were randomly divided into seven groups (n=8) as follows; Group I is normal control; Groups II and III were normal rats treated with 50 and 100 mg/kg respectively; Group IV–VII were STZ-induced rats, but Groups V–VII were treated with acarbose (25 mg/kg), 50 and 100 mg/kg of BER, respectively.

Results

The result of the study showed that untreated STZ-induced diabetic rats have increased acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO) activities, and malonylaldehyde (MDA) level, with concomitant decrease of superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, and glutathione (GSH) level. However, daily treatment with 50 and 100 mg/kg BER and ACA significantly reversed these effects.

Conclusions

The findings of this study clearly indicated that BER possesses neuro-protective and antioxidative potentials and normalize neurochemical impairment distort by diabetes.

Keywords: antioxidant; brain; cholinesterase; diabetes; monoamine; neurotransmitters
Corresponding author: Felix A. Dada, Science Laboratory Technology Department (Biochemistry Unit), Federal Polytechnic Ede, P.M.B 231, Ede, Osun State, Nigeria, Phone: +234 8067509611, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval: All the animals received humane care according to the criteria outlined in the guide for the care and use of laboratory animals prepared by the National Academy of Science and published by the National Institute of Health (USA). The animal ethic committee of the Federal University of Technology, Akure, Nigeria gave an approval for the use of laboratory animals with reference number of FUTA/ETH/2020/014. The ethic regulations are in accordance with national and institutional guidelines for the protection of animals’ welfare during experiments.

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Received: 2020-06-03
Accepted: 2021-01-23
Published Online: 2021-03-16

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Minireview
  3. Can pulse wave velocity (PWV) alone express arterial stiffness? A neglected tool for vascular function assessment
  4. Review
  5. Hyponatremia in heart failure: not just 135 to 145
  6. Original Articles
  7. Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
  8. Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats
  9. Terminalia arjuna supplementation ameliorates high fat diet-induced oxidative stress in nephrotoxic rats
  10. Decreased expression of annexin A2 and loss of its association with vascular endothelial growth factor leads to the deficient trophoblastic invasion in preeclampsia
  11. Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models
  12. Assessment of sleep quality and its predictors among newly diagnosed psychiatric patients
  13. Ovalbumin/lipopolysaccharide induced vasculitis in rats: a new predictive model
  14. Dose-dependent and time-dependent metabolic, hemodynamic, and redox disturbances in dexamethasone-treated Wistar rats
  15. Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio
  16. Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-κB in rats subjected to experimental pancreatitis – influence of HSP70
  17. Effects of Onosma dichroanthum Boiss. root extract on AGS human gastric cancer cell-line
  18. Feasibility, face, and content validity of quantitative computed tomography in interstitial lung disease related to connective tissue diseases
  19. In vitro anticoagulant activity of selected medicinal plants: potential interactions with warfarin and development of new anticoagulants
  20. Normal reference value of orthodromic and antidromic sensory nerve conduction velocity of median nerve with intact palmaris longus tendon in apparently healthy individuals
  21. Short Communication
  22. Chemokine receptor antagonists with α1-adrenergic receptor blocker activity
https://doi.org/10.1515/jbcpp-2020-0173
Schlagwörter für diesen Artikel
antioxidant; brain; cholinesterase; diabetes; monoamine; neurotransmitters

Artikel in diesem Heft

  1. Frontmatter
  2. Minireview
  3. Can pulse wave velocity (PWV) alone express arterial stiffness? A neglected tool for vascular function assessment
  4. Review
  5. Hyponatremia in heart failure: not just 135 to 145
  6. Original Articles
  7. Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
  8. Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats
  9. Terminalia arjuna supplementation ameliorates high fat diet-induced oxidative stress in nephrotoxic rats
  10. Decreased expression of annexin A2 and loss of its association with vascular endothelial growth factor leads to the deficient trophoblastic invasion in preeclampsia
  11. Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models
  12. Assessment of sleep quality and its predictors among newly diagnosed psychiatric patients
  13. Ovalbumin/lipopolysaccharide induced vasculitis in rats: a new predictive model
  14. Dose-dependent and time-dependent metabolic, hemodynamic, and redox disturbances in dexamethasone-treated Wistar rats
  15. Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio
  16. Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-κB in rats subjected to experimental pancreatitis – influence of HSP70
  17. Effects of Onosma dichroanthum Boiss. root extract on AGS human gastric cancer cell-line
  18. Feasibility, face, and content validity of quantitative computed tomography in interstitial lung disease related to connective tissue diseases
  19. In vitro anticoagulant activity of selected medicinal plants: potential interactions with warfarin and development of new anticoagulants
  20. Normal reference value of orthodromic and antidromic sensory nerve conduction velocity of median nerve with intact palmaris longus tendon in apparently healthy individuals
  21. Short Communication
  22. Chemokine receptor antagonists with α1-adrenergic receptor blocker activity
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