Abstract
Background: The phytochemical constituents of the aqueous root extract of Lecaniodiscus cupanioides Planch. Ex Bth. and its aphrodisiac activity on male rat sexual behavior and reproductive hormones in paroxetine-induced sexual dysfunction were evaluated.
Methods: The extract was screened for the presence of phytochemicals. The extract (25, 50, and 100 mg/kg body weight) and the reference herbal drug PowmaxM (7.14 mg/kg body weight) were administered orally to paroxetine-induced sexually impaired male rats, once daily for 5 days, and their sexual behavior parameters were monitored and computed. The serum hormones (testosterone, follicle-stimulating hormone, and luteinizing hormone) were determined at the end of treatment period.
Results: Phytochemical screening revealed the presence of alkaloids, anthraquinones, phenolics, saponins, and tannins. Mount frequency (MF), intromission frequency (IF), ejaculatory frequency (EF), and testosterone, follicle-stimulating hormone, and luteinizing hormone concentrations were reduced significantly (p<0.05) in paroxetine-treated rats. Administration of 25, 50, and 100 mg/kg body weight of the aqueous root extract of L. cupanioides significantly (p<0.05) reversed the paroxetine-mediated alterations in MF, IF, EF, mount latency (ML), intromission latency (IL), ejaculatory latency (EL), postejaculatory interval (PEI), and testosterone, follicle-stimulating hormone, and luteinizing hormone concentrations dose-dependently. The reversal of the male sexual behavior parameters by the extract compared well (p<0.05) with the PowmaxM-treated animals.
Conclusions: Data obtained from this study revealed that the aqueous root extract of L. cupanioides restored sexual competence in sexually impaired rats possibly by increasing sexual drive through enhanced reproductive hormones concentration, particularly testosterone, thus supporting the folkloric claim of the plant for the management of sexual disorder in males.
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©2014 by Walter de Gruyter Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Cerebral stroke injury: the role of cytokines and brain inflammation
- Cardiovascular-Pulmonary Interactions
- Gene functional dynamics: environment as a trigger?
- Arrhythmogenesis after acute myocardial necrosis with and without preceding ischemia in rats
- Measuring cardiopulmonary parameters during dual-task while walking
- Calcium-dependent mechanisms mediate the vasorelaxant effects of Tridax procumbens (Lin) aqueous leaf extract in rat aortic ring
- Inflammation
- Effects of cyclosporine and phenytoin on biomarker expressions in gingival fibroblasts of children and adults: an in vitro study
- Anti-inflammatory and analgesic activities of the methanol leaf extract of Phyllanthus amarus in some laboratory animals
- Oxidative Stress
- Ameliorative effect of diallyl trisulphide on arsenic-induced oxidative stress in rat erythrocytes and DNA damage in lymphocytes
- Anticholinesterase and antioxidative properties of water-extractable phytochemicals from some citrus peels
- Immune Response
- Temporal expression of IL-1β and IL-10 in rat skin, muscle, small bowel, and colon wounds: a correlative study
- Augmented primary humoral immune response and decreased cell-mediated immunity by Murraya koenigii in rats
- Analgesic, anti-inflammatory, and heme biomineralization inhibitory properties of Entada africana ethanol leaf extract with antiplasmodial activity against Plasmodium falciparum
- Hematological Profile
- Hematological profile in neonatal jaundice
- Effects of blood lead level on biochemical and hematological parameters in children with neurological diseases of Western Maharashtra, India
- Phytotherapy
- Antipsychotic property of solvent-partitioned fractions of Lonchocarpus cyanescens leaf extract in mice
- Aphrodisiac effect of aqueous root extract of Lecaniodiscus cupanioides in sexually impaired rats
- Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole
- Metabolism
- Evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of Piper nigrum, Murraya koenigii, Argemone mexicana, and Nelumbo nucifera
Artikel in diesem Heft
- Frontmatter
- Review
- Cerebral stroke injury: the role of cytokines and brain inflammation
- Cardiovascular-Pulmonary Interactions
- Gene functional dynamics: environment as a trigger?
- Arrhythmogenesis after acute myocardial necrosis with and without preceding ischemia in rats
- Measuring cardiopulmonary parameters during dual-task while walking
- Calcium-dependent mechanisms mediate the vasorelaxant effects of Tridax procumbens (Lin) aqueous leaf extract in rat aortic ring
- Inflammation
- Effects of cyclosporine and phenytoin on biomarker expressions in gingival fibroblasts of children and adults: an in vitro study
- Anti-inflammatory and analgesic activities of the methanol leaf extract of Phyllanthus amarus in some laboratory animals
- Oxidative Stress
- Ameliorative effect of diallyl trisulphide on arsenic-induced oxidative stress in rat erythrocytes and DNA damage in lymphocytes
- Anticholinesterase and antioxidative properties of water-extractable phytochemicals from some citrus peels
- Immune Response
- Temporal expression of IL-1β and IL-10 in rat skin, muscle, small bowel, and colon wounds: a correlative study
- Augmented primary humoral immune response and decreased cell-mediated immunity by Murraya koenigii in rats
- Analgesic, anti-inflammatory, and heme biomineralization inhibitory properties of Entada africana ethanol leaf extract with antiplasmodial activity against Plasmodium falciparum
- Hematological Profile
- Hematological profile in neonatal jaundice
- Effects of blood lead level on biochemical and hematological parameters in children with neurological diseases of Western Maharashtra, India
- Phytotherapy
- Antipsychotic property of solvent-partitioned fractions of Lonchocarpus cyanescens leaf extract in mice
- Aphrodisiac effect of aqueous root extract of Lecaniodiscus cupanioides in sexually impaired rats
- Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole
- Metabolism
- Evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of Piper nigrum, Murraya koenigii, Argemone mexicana, and Nelumbo nucifera