Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats
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Ademola A. Oyagbemi
, Temitayo O. Omobowale
, Ibraheem O. Azeez , John O. Abiola , Rahamon A.M. Adedokun und Helen O. Nottidge
Abstract
Background: This study was conducted to investigate toxicological effects associated with prolonged consumption of Moringa oleifera leaves as a beverage.
Methods: Thirty rats were used in this study. They were grouped into five groups of six rats. Rats in group I received 2 mL/kg body weight (b.w.) of corn oil (vehicle). Animals in groups II, III, IV and V received 50, 100, 200 and 400 mg/kg b.w. of methanolic extract of M. oleifera (MEMO) for 8 weeks. Serum collected was analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, blood urea nitrogen (BUN) and creatinine.
Results: There was a significant (p<0.05) increase in serum total protein and globulin in a dose-dependent manner. Rats that received MEMO at 200 and 400 mg/kg b.w. showed a significant (p<0.05) increase in serum ALT, AST, BUN and creatinine which pointed to hepatic and kidney damage. All experimental animals that received MEMO had a significant (p<0.05) increase in body weight in a dose-dependent manner.
Conclusions: This study therefore confirms for the first time that chronic administration of M. oleifera leaves might predispose to hepatic and kidney damage.
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- Masthead
- Masthead
- Review
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- Original Articles
- Distribution of performance-related gene polymorphisms (ACTN3 R577X and ACE ID) in different ethnic groups of the Indian Army
- Birth month and longevity: birth month of victims of sudden (SCD, ≤1 h) and rapid (RCD, ≤24 h) cardiac deaths
- Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) polymorphism is associated with chronic inflammatory periodontitis. A cross-sectional study
- The effect of coadministration of α-tocopherol and ascorbic acid on arsenic trioxide-induced testicular toxicity in adult rats
- Effect of acute immobilization stress with or without a heme oxygenase inducer on testicular structure and function in male albino rats
- Effect of Jobelyn® on intruder- and isolation-induced aggressive behavior in mice
- Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory T-cell differentiation in alloreactive human lymphocytes
- Antinociceptive, anti-inflammatory and antiulcerogenic activities of ethanol root extract of Strophanthus hispidus DC (Apocynaceae)
- Acrolein-induced inflammatory signaling in vascular smooth muscle cells requires activation of serum response factor (SRF) and NFκB
- Nephroprotective activity of Cocculus hirsutus leaf extract in 5/6 nephrectomized rat model
- Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats
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