The effect of erythropoietin on phosphorus levels during hypoxia reoxygenation injury in rats
-
Constantinos Tsompos
,
Constantinos Panoulis
Abstract
Background:
The aim of this experimental study was to examine the effect of erythropoietin (Epo) in a rat model and particularly in a hypoxia-reoxygenation (HR) protocol. The beneficial effect or non-effectiveness of that molecule were studied biochemically using blood mean phosphorus (P) levels.
Methods:
Forty rats of mean weight 247.7 g were used in the study. P levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) from reoxygenation. Epo was administered only in groups C and D.
Results:
Epo administration non-significantly increased P levels by 3.95%±3.35% (p=0.2100). Reperfusion time non-significantly decreased P levels by 0.35%±3.40% (p=0.9041). However, Epo administration and reperfusion time together produced a non-significant combined effect in increasing P levels by 2.45%±2.01% (p=0.2168).
Conclusion:
Epo administration, interacting or not with reperfusion time, has non-significant short-term increasing effects on P levels.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This study was funded by scholarship by the Experimental Research Center ELPEN Pharmaceuticals (E.R.C.E), Athens, Greece. The research facilities for this project were provided by the aforementioned institution.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial
- Birth defects and human development
- Original Articles
- Perceived parental differential treatment, cognition, behaviour and family cohesiveness among siblings of children with cerebral palsy? A family-mediated intervention to understand “displaced” children
- Alterations in body composition, capillary glucose and functionality during explosive strength training in older women
- People with multiple disabilities use assistive technology to perform complex activities at the appropriate time
- The relationship between family dining practices, parenting style and family functioning and child learning
- A procedure to correct the effect of heart rate on heart rate variability indices: description and assessment
- Psychological and emotional state of parents having intellectually and developmentally disabled children
- Predictors of quality of life in people with intellectual disability in Bosnia and Herzegovina
- The effect of erythropoietin on phosphorus levels during hypoxia reoxygenation injury in rats
- Opportunities for disabled people through ICTs: a perspective from Turkey
- A review of adolescent prevention and positive youth development programs in non-English speaking European countries
- Assessing learning gains of university students in Hong Kong adopting the Collegiate Learning Assessment Plus (CLA+)
- Student feedback on a subject on leadership and intrapersonal development for university students in Hong Kong
Artikel in diesem Heft
- Frontmatter
- Editorial
- Birth defects and human development
- Original Articles
- Perceived parental differential treatment, cognition, behaviour and family cohesiveness among siblings of children with cerebral palsy? A family-mediated intervention to understand “displaced” children
- Alterations in body composition, capillary glucose and functionality during explosive strength training in older women
- People with multiple disabilities use assistive technology to perform complex activities at the appropriate time
- The relationship between family dining practices, parenting style and family functioning and child learning
- A procedure to correct the effect of heart rate on heart rate variability indices: description and assessment
- Psychological and emotional state of parents having intellectually and developmentally disabled children
- Predictors of quality of life in people with intellectual disability in Bosnia and Herzegovina
- The effect of erythropoietin on phosphorus levels during hypoxia reoxygenation injury in rats
- Opportunities for disabled people through ICTs: a perspective from Turkey
- A review of adolescent prevention and positive youth development programs in non-English speaking European countries
- Assessing learning gains of university students in Hong Kong adopting the Collegiate Learning Assessment Plus (CLA+)
- Student feedback on a subject on leadership and intrapersonal development for university students in Hong Kong
