Startseite Analysis of the Long Time Behavior of Enzymatic Cellulose Hydrolysis Kinetics
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Analysis of the Long Time Behavior of Enzymatic Cellulose Hydrolysis Kinetics

  • S Ramakrishnan EMAIL logo , G Brodeur und J. C Telotte
Veröffentlicht/Copyright: 5. Dezember 2017
Veröffentlichen auch Sie bei De Gruyter Brill

Abstract

Enzymatic hydrolysis of biomass to produce sugars that can be converted to fuels and other valuable chemicals, is viewed as the prime technology for utilization of this renewable resource. To accelerate technology development, models are needed that are able to accurately predict the hydrolysis rate so that reactors can be tailored to the multitude of processing conditions and substrates that can be used. Of particular interest is the ability to predict the long time conversion in the hydrolysis reaction which dictates the maximum possible sugar concentration. It is our aim in this article to develop a simple model which is able to predict the long-term conversion of cellulose to soluble sugars. Drawing on the analogy from the theory of reactions in continuous mixtures, it is shown that analysis of the long time kinetics of hydrolysis by examining the behavior of the “lump” of the reacting material results in a simple expression which is capable of predicting the kinetics. Many features of actual enzyme systems can be included in the development of the hydrolysis model, such as the large size of the enzyme molecules, adsorption onto substrate, inhibition by different factors (solvent, glucose etc.), but, when the analysis is carried out to calculate the total sugar concentration, it is shown that the equations reduce to a simple expression. Analysis of this model is given with comparison to other models and experimental data available in the literature. In addition to predicting the long-term kinetics, it is shown that the model does a surprising job of predicting the initial hydrolysis rates as well.

Acknowledgements

Funding for this research was provided by the Southeastern SunGrant Center, a program supported by the US Department of Transportation. S. Ramakrishnan and J. Telotte would also like to thank Bush Brothers for partial financial support. We would like to thank J. J. Stickel of the National Renewable Energy Laboratory for discussions and insights.

References

Andrić, P., A. Meyer, P. Jensen, and K. Dam-Johansen. 2010. “Effect and Modeling of Glucose Inhibition and in Situ Glucose Removal during Enzymatic Hydrolysis of Pretreated Wheat Straw.” Applied Biochemistry and Biotechnology 160 (1):280–297.10.1007/s12010-008-8512-9Suche in Google Scholar PubMed

Aris, R., and G. R. Gavalas. 1966. “On the Theory of Reactions in Continuous Mixtures.” Proceedings of Royal Society London, Series A 260:351–393.Suche in Google Scholar

Astarita, G. 1989. “Lumping Nonlinear Kinetics: Apparent Overall Order of Reactions.” AIChE Journal 35:529–532.10.1002/aic.690350402Suche in Google Scholar

Astarita, G., and R. Ocone. 1988. “Lumping Nonlinear Kinetics.” AIChE Journal 34:1299–1305.10.1002/aic.690340808Suche in Google Scholar

Brodeur, G., 2013. Developing a Novel Two Stage Pretreatment of Lignocellulosic Biomass for Enhanced Bioprocessing. Ph. D. Chemical and Biomedical Engineering. Ph.D., Florida State University.Suche in Google Scholar

Brodeur, G., J. Telotte, J. J. Stickel, and S. Ramakrishnan. 2016. “Two-Stage Dilute-Acid and Organic-Solvent Lignocellulosic Pretreatment for Enhanced Bioprocessing.” Bioresource Technology 220:621–628.10.1016/j.biortech.2016.08.089Suche in Google Scholar PubMed

Brodeur, G., E. Yau, J. Collier, J. Telotte, and S. Ramakrishnan. 2017. “Effect of Solids Loading and Solvent Type on the Enzymatic Hydrolysis of Cellulose.” Journal of Chemical Technology and Biotechnology 92 (1):224–229.10.1002/jctb.4972Suche in Google Scholar

Brown, R. F., and M. T. Holtzapple. 1990. “A Comparison of the Michaelis-Menton and HCH-1 Models.” Biotechnology and Bioengineering 36 (11):1151–1154.10.1002/bit.260361110Suche in Google Scholar PubMed

Chong, G. G., Y. C. He, Q. X. Liu, X. Q. Kou, and Q. Qing. 2017. “Sequential Aqueous Ammonia Extraction and LiCl/N,N-Dimethyl Formamide Pretreatment for Enhancing Enzymatic Saccharification of Winter Bamboo Shoot Shell.” Applied Biochemistry and Biotechnology 182 (4):1341–1357.10.1007/s12010-017-2402-ySuche in Google Scholar PubMed

Chou, M. Y., and T. C. Ho. 1989. “Lumping Coupled Nonlinear Reactions in Continuous Mixtures.” AIChE Journal 35:533–538.10.1002/aic.690350403Suche in Google Scholar

Dwivedi, C. P., and T. K. Ghose. 1979. “Model on Hydrolysis of Bagasse Cellulose by Enzyme from Trichoderma-Reesei QM-9414.” Journal of Fermentation Technology 57 (1):15–24.Suche in Google Scholar

Fan, L. T., Y. H. Lee, and D. R. Beardmore. 1981. “The Influence of Major Structural Features of Cellulose on Rate of Enzymatic Hydrolysis.” Biotechnology and Bioengineering 23 (2):419–424.10.1002/bit.260230215Suche in Google Scholar

Gallo, J. M. R., and M. A. Trapp. 2017. “The Chemical Conversion of Biomass-Derived Saccharides: An Overview.” Journal of the Brazilian Chemical Society 28 (9):1586–1607.10.21577/0103-5053.20170009Suche in Google Scholar

Gan, Q., S. J. Allen, and G. Taylor. 2003. “Kinetic Dynamics in Heterogeneous Enzymatic Hydrolysis of Cellulose: An Overview, an Experimental Study and Mathematical Modelling.” Process Biochemistry 38 (7):1003–1018.10.1016/S0032-9592(02)00220-0Suche in Google Scholar

Geddes, C. C., J. J. Peterson, M. T. Mullinnix, S. A. Svoronos, K. T. Shanmugam, and L. O. Ingram. 2010. “Optimizing Cellulase Usage for Improved Mixing and Rheological Properties of Acid-Pretreated Sugarcane Bagasse.” Bioresource Technology 101 (23):9128–9136.10.1016/j.biortech.2010.07.040Suche in Google Scholar PubMed

Ghose, T. K., and K. Das. 1971. “A Simplified Kinetics Approach to Cellulose-Cellulase System.” Advances in Biochemical Engineering 1:55.10.1007/BFb0044730Suche in Google Scholar

Griggs, A. J., J. J. Stickel, and J. J. Lischeske. 2012a. “A Mechanistic Model for Enzymatic Saccharification of Cellulose Using Continuous Distribution Kinetics I: Depolymerization by EGI and CBHI.” Biotechnology and Bioengineering 109:665–675.10.1002/bit.23355Suche in Google Scholar PubMed

Griggs, A. J., J. J. Stickel, and J. J. Lischeske. 2012b. “A Mechanistic Model for Enzymatic Saccharification of Cellulose Using Continuous Distribution Kinetics II: Cooperative Enzyme Action, Solution Kinetics and Product Inhibition.” Biotechnology and Bioengineering 109:676–685.10.1002/bit.23354Suche in Google Scholar PubMed

Gubicza, K., I. U. Nieves, W. J. Sagues, Z. Barta, K. T. Shanmugam, and L. O. Ingram. 2016. “Techno-Economic Analysis of Ethanol Production from Sugarcane Bagasse Using a Liquefaction Plus Simultaneous Saccharification and co-Fermentation Process.” Bioresource Technology 208:42–48.10.1016/j.biortech.2016.01.093Suche in Google Scholar PubMed

Guo, B., Y. Zhang, G. Yu, W.-H. Lee, Y.-S. Jin, and E. Morgenroth. 2013. “Two-Stage Acidic–Alkaline Hydrothermal Pretreatment of Lignocellulose for the High Recovery of Cellulose and Hemicellulose Sugars.” Applied Biochemistry and Biotechnology 169 (4):1069–1087.10.1007/s12010-012-0038-5Suche in Google Scholar PubMed

Holmgren, J., R. Marinangeli, P. Nair, D. Elliott, and R. Bain. 2008. “Consider Upgrading Pyrolysis Oils into Renewable Fuels.” Hydrocarbon Processing 87 (9):95–+.Suche in Google Scholar

Holtzapple, M. T., H. S. Caram, and A. E. Humphrey. 1984a. “A Comparison of 2 Empirical Models for Enzymatic Hydrolysis of Pretreated Poplar Wood.” Biotechnology and Bioengineering 26 (8):936–941.10.1002/bit.260260818Suche in Google Scholar PubMed

Holtzapple, M. T., H. S. Caram, and A. E. Humphrey. 1984b. “The HCH-1 Model of Enzymatic Cellulose Hydrolysis.” Biotechnology and Bioengineering 26 (7):775–780.10.1002/bit.260260723Suche in Google Scholar PubMed

Howell, J. A., and J. D. Stuck. 1975. “Kinetics of Solka Floc Cellulose Hydorlysis by Trichoderma-Viride Cellulase.” Biotechnology and Bioengineering 17 (6):873–893.10.1002/bit.260170608Suche in Google Scholar

Huang, A. A. 1975. “Kinetic Studies on Insoluble Cellulose-Cellulase System.” Biotechnology and Bioengineering 17 (10):1421–1433.10.1002/bit.260171003Suche in Google Scholar

Huron, M., D. Hudebine, N. L. Ferreira, and D. Lachenal. 2016. “Mechanistic Modeling of Enzymatic Hydrolysis of Cellulose Integrating Substrate Morphology and Cocktail Composition.” Biotechnology and Bioengineering 113 (5):1011–1023.10.1002/bit.25873Suche in Google Scholar

Hymphrey, A. E. 1979. Hydrolysis of Cellulose: Mechanisms of Enzymatic and Acid Catalysis. The Hydrolysis of Cellulosic Materials to Useful Products. Washington, DC: American Chemical Society.10.1021/ba-1979-0181.ch002Suche in Google Scholar

Jeoh, T., M. J. Cardona, N. Karuna, A. R. Mudinoor, and J. Nill. 2017. “Mechanistic Kinetic Models of Enzymatic Cellulose hydrolysisA Review.” Biotechnology and Bioengineering 114 (7):1369–1385.10.1002/bit.26277Suche in Google Scholar

Koullas, D. P., P. Christakopoulos, D. Kekos, B. J. Macris, and E. G. Koukios. 1992. “Correlating the Effect of Pretreatment on the Enzymatic Hydrolysis of Straw.” Biotechnology and Bioengineering 39 (1):113–116.10.1002/bit.260390116Suche in Google Scholar

Kumar, A., D. D. Jones, and M. A. Hanna. 2009. “Thermochemical Biomass Gasification: A Review of the Current Status of the Technology.” Energies 2 (3):556–581.10.3390/en20300556Suche in Google Scholar

Loow, Y. L., E. K. New, G. H. Yang, L. Y. Ang, L. Y. W. Foo, and T. Y. Wu. 2017. “Potential Use of Deep Eutectic Solvents to Facilitate Lignocellulosic Biomass Utilization and Conversion.” Cellulose 24 (9):3591–3618.10.1007/s10570-017-1358-ySuche in Google Scholar

Martinez-Patino, J. C., E. Ruiz, I. Romero, C. Cara, J. C. Lopez-Linares, and E. Castro. 2017. “Combined Acid/Alkaline-Peroxide Pretreatment of Olive Tree Biomass for Bioethanol Production.” Bioresource Technology 239:326–335.10.1016/j.biortech.2017.04.102Suche in Google Scholar

Movagharnejad, K., and M. Sohrabi. 2003. “A Model for the Rate of Enzymatic Hydrolysis of Some Cellulosic Waste Materials in Heterogeneous Solid-Liquid Systems.” Biochemical Engineering Journal 14 (1):1–8.10.1016/S1369-703X(02)00104-3Suche in Google Scholar

Nag, A., M. A. Sprague, A. J. Griggs, J. J. Lischeske, J. J. Stickel, A. Mittal, W. Wang, and D. K. Johnson. 2015. “Parameter Determination and Validation for a Mechanistic Model of the Enzymatic Saccharification of cellulose-I-beta.” Biotechnology Progress 31 (5):1237–1248.10.1002/btpr.2122Suche in Google Scholar PubMed

O’Dwyer, J. P., L. Zhu, C. B. Granda, and M. T. Holtzapple. 2007. “Enzymatic Hydrolysis of Lime-Pretreated Corn Stover and Investigation of the HCH-1 Model: Inhibition Pattern, Degree of Inhibition, Validity of Simplified HCH-1 Model.” Bioresource Technology 98 (16):2969–2977.10.1016/j.biortech.2006.10.014Suche in Google Scholar PubMed

Ohmine, K., H. Ooshima, and Y. Harano. 1983. “Kinetic Study on Enzymatic Hydrolysis of Cellulose by Cellulose from Trichoderma Viride.” Biotechnology and Bioengineering 25 (8):2041–2053.10.1002/bit.260250813Suche in Google Scholar PubMed

Oyetunji, R., 2009. Enzymatic Hydrolysis of Cellulose in a NMMO/H2O Solution. M.S. Chemical and Biomedical Engineering. M.S., Florida State University.Suche in Google Scholar

Peri, S., S. Karra, Y. Y. Lee, and M. N. Karim. 2007. “Modeling Intrinsic Kinetics of Enzymatic Cellulose Hydrolysis.” Biotechnology Progress 23 (3):626–637.10.1021/bp060322sSuche in Google Scholar PubMed

Poornejad, N., K. Karimi, and T. Behzad. 2011. “Improvement of Saccharification and Ethanol Production from Rice Straw by NMMO and [Bmim][Oac] Pretreatments.” Industrial Crops and Products 41 (0):408–413.10.1016/j.indcrop.2012.04.059Suche in Google Scholar

Ramakrishnan, S., J. Collier, R. Oyetunji, B. Stutts, and R. Burnett. 2010. “Enzymatic Hydrolysis of Cellulose Dissolved in N-Methyl Morpholine Oxide/Water Solutions.” Bioresource Technology 101 (13):4965–4970.10.1016/j.biortech.2009.09.002Suche in Google Scholar PubMed

Rollin, J. A., Z. Zhu, N. Sathitsuksanoh, and Y. H. P. Zhang. 2011. “Increasing Cellulose Accessibility Is More Important than Removing Lignin: A Comparison of Cellulose Solvent-Based Lignocellulose Fractionation and Soaking in Aqueous Ammonia.” Biotechnology and Bioengineering 108 (1):22–30.10.1002/bit.22919Suche in Google Scholar PubMed

Serrano-Ruiz, J. C., and J. A. Dumesic. 2011. “Catalytic Routes for the Conversion of Biomass into Liquid Hydrocarbon Transportation Fuels.” Energy Environment Sciences 4 (1):83–99.10.1039/C0EE00436GSuche in Google Scholar

Stickel, J. J., and A. J. Griggs. 2012. “Mathematical Modeling of Chain End Scission Using Continuous Distribution Kinetics.” Chemical Engineering Science 68:656–659.10.1016/j.ces.2011.09.028Suche in Google Scholar

Teymouri, F., L. Laureano-Perez, H. Alizadeh, and B. E. Dale. 2005. “Optimization of the Ammonia Fiber Explosion (AFEX) Treatment Parameters for Enzymatic Hydrolysis of Corn Stover.” Bioresource Technology 96 (18):2014–2018.10.1016/j.biortech.2005.01.016Suche in Google Scholar PubMed

Wald, S., C. R. Wilke, and H. W. Blanch. 1984. “Kinetics of the Enzymatic Hydrolysis of Cellulose.” Biotechnology and Bioengineering 26 (3):221–230.10.1002/bit.260260305Suche in Google Scholar PubMed

Wang, K., H. Y. Yang, F. Xu, and R. C. Sun. 2011. “Structural Comparison and Enhanced Enzymatic Hydrolysis of the Cellulosic Preparation from Populus Tomentosa Carr., By Different Cellulose-Soluble Solvent Systems.” Bioresource Technology 102 (6):4524–4529.10.1016/j.biortech.2010.12.088Suche in Google Scholar PubMed

Yau, E., 2012. Enzymatic Hydrolysis of Cellulose Pretreated with Ionic Liquid and N-Methyl Morpholine N-Oxide. M.S. Chemical and Biomedical Engineering. M.S., Florida State University.Suche in Google Scholar

Zhang, Y. H. P., and L. R. Lynd. 2004. “Toward an Aggregated Understanding of Enzymatic Hydrolysis of Cellulose: Noncomplexed Cellulase Systems.” Biotechnology and Bioengineering 88 (7):797–824.10.1002/bit.20282Suche in Google Scholar PubMed

Zhang, Y. H. P., and L. R. Lynd. 2006. “A Functionally Based Model for Hydrolysis of Cellulose by Fungal Cellulase.” Biotechnology and Bioengineering 94 (5):888–898.10.1002/bit.20906Suche in Google Scholar PubMed

Received: 2017-5-22
Accepted: 2017-10-20
Published Online: 2017-12-5

© 2018 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 16.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/ijcre-2017-0087/html
Button zum nach oben scrollen