Startseite The good or the bad: an overview of autoantibodies in traumatic spinal cord injury
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The good or the bad: an overview of autoantibodies in traumatic spinal cord injury

  • Annika Guntermann ORCID logo , Katrin Marcus ORCID logo und Caroline May ORCID logo EMAIL logo
Veröffentlicht/Copyright: 3. Oktober 2023

Abstract

Infections remain the most common cause of death after traumatic spinal cord injury, likely due to a developing immune deficiency syndrome. This, together with a somewhat contradictory development of autoimmunity in many patients, are two major components of the maladaptive systemic immune response. Although the local non-resolving inflammation in the lesioned spinal cord may lead to an antibody formation against autoantigens of the injured spinal cord tissue, there are also natural (pre-existing) autoantibodies independent of the injury. The way in which these autoantibodies with different origins affect the neuronal and functional outcome of spinal cord-injured patients is still controversial.


Corresponding author: Caroline May, Medical Proteome Analysis, Center for Protein Diagnostics (ProDi), Ruhr University Bochum, D-44801 Bochum, Germany; and Medizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, Gesundheitscampus 4, D-44801 Bochum, Germany, E-mail:

  1. Research ethics: Not applicable.

  2. Author contributions: A.G. and C.M. planned and wrote the manuscript. K.M. proofread the manuscript. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors state no conflict of interests.

  4. Research funding: This work was supported by the European Union (EU ERA-NET Neuron Program, SILENCE Grant 01 EW170A), the HUPO Brain Proteome Project (HBPP) and the Protein research Unit Ruhr within Europe (PURE). A.G. was supported by the Heinrich und Alma Vogelsang Stiftung and by the Boehringer Ingelheim Fonds.

  5. Data availability: Not applicable.

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Received: 2023-06-30
Accepted: 2023-09-12
Published Online: 2023-10-03
Published in Print: 2024-01-29

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