Highlight: chemical biology of ion channels

Artikel in diesem Heft

1. Frontmatter
2. Highlight: Chemical Biology of Ion Channels
3. Highlight: chemical biology of ion channels
4. The second PI(3,5)P₂ binding site in the S0 helix of KCNQ1 stabilizes PIP₂-at the primary PI1 site with potential consequences on intermediate-to-open state transition
5. In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs
6. A novel NMDA receptor test model based on hiPSC-derived neural cells
7. Chemical, pharmacodynamic and pharmacokinetic characterization of the GluN2B receptor antagonist 3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol – starting point for PET tracer development
8. Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice
9. Influence of inflammatory processes on thalamocortical activity
10. NMDA receptors – regulatory function and pathophysiological significance for pancreatic beta cells
11. The role of the Na⁺/Ca²⁺-exchanger (NCX) in cancer-associated fibroblasts
12. Pancreatic K_Ca3.1 channels in health and disease
13. Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation