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The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function

  • Sudheendra Hebbar Subramanyam

    Sudheendra Hebbar Subramanyam received his MSc at the University of Bochum in 2019. He is currently performing his PhD studies in the lab of Klaus Tenbrock on the topic of Treg specific knockout of CREB.

         and Klaus Tenbrock

    Klaus Tenbrock received his MD at the RWTH Aachen, Germany followed by clinical education at the University of Cologne and research positions at the Walter Reed Army Institute of research and a group leader position at the IZKF Münster 2003–2007. He is currently professor at the Department of Pediatrics in Aachen and head of the Division of Pediatric Pneumology, Allergology and Immunology. His work is centered on transcriptional and metabolic regulation of the immune system with a focus of pediatric autoimmune diseases. He is member of the IZKF Aachen since 2008.

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Published/Copyright: August 26, 2021
Biological Chemistry
From the journal Biological Chemistry Volume 402 Issue 12

Abstract

The cAMP responsive element modulator (CREM) is a transcriptional regulator of different effector cytokines in CD4+ T cells including IL-2, IL-17, IL-21 but also IL-4 and IL-13 and thus an important determinant of central T helper cell functions. Our review gives an overview over the regulation of CREM in T cells and the pleiotropic effects of CREM on CD4+ T cells in health and autoimmune diseases with a particular focus on systemic lupus erythematosus.

Keywords: cAMP; CREMα; ICER; interleukin 2; metabolism; Th17
Corresponding author: Klaus Tenbrock, Department of Pediatrics, Pediatric Pneumology, Allergology and Immunology, RWTH Aachen University, Aachen, Germany; Interdisciplinary Center for Clinical Research IZKF, Aachen, Germany; and Interdisciplinary Center for Clinical Research IZKF, Münster, Germany, E-mail:
This article is a contribution to the issue highlighting the 25th Anniversary of the Interdisciplinary Centre for Clinical Research (IZKF) Münster.

Funding source: Interdisciplinary center for clinical research IZKF AachenInterdisciplinary center for clinical research IZKF Münster

Award Identifier / Grant number: B4/2014

Award Identifier / Grant number: FG5/03

About the authors

Sudheendra Hebbar Subramanyam

Sudheendra Hebbar Subramanyam received his MSc at the University of Bochum in 2019. He is currently performing his PhD studies in the lab of Klaus Tenbrock on the topic of Treg specific knockout of CREB.

Klaus Tenbrock

Klaus Tenbrock received his MD at the RWTH Aachen, Germany followed by clinical education at the University of Cologne and research positions at the Walter Reed Army Institute of research and a group leader position at the IZKF Münster 2003–2007. He is currently professor at the Department of Pediatrics in Aachen and head of the Division of Pediatric Pneumology, Allergology and Immunology. His work is centered on transcriptional and metabolic regulation of the immune system with a focus of pediatric autoimmune diseases. He is member of the IZKF Aachen since 2008.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research Funding: This work was partially funded by Interdisciplinary center for clinical research IZKF Aachen B4/2014 and Interdisciplinary center for clinical research IZKF Münster FG5/03

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2021-05-03
Accepted: 2021-08-10
Published Online: 2021-08-26
Published in Print: 2021-11-25

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Highlight: Molecular Determinants of Health and Disease - 25th Anniversary of the InterdisciplinaryCenter Clinical Research Münster
  3. Molecular determinants of health and disease
  4. Role of the gut microbiota in airway immunity and host defense against respiratory infections
  5. Dynamic phospho-modification of viral proteins as a crucial regulatory layer of influenza A virus replication and innate immune responses
  6. Molecular mechanisms of vasculopathy and coagulopathy in COVID-19
  7. Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment
  8. Epitranscriptomic modifications in acute myeloid leukemia: m6A and 2′-O-methylation as targets for novel therapeutic strategies
  9. Molecular determinants of therapy response of venetoclax-based combinations in acute myeloid leukemia
  10. Pseudomonas aeruginosa and Staphylococcus aureus virulence factors as biomarkers of infection
  11. Controllers of cutaneous regulatory T cells: ultraviolet radiation and the skin microbiome
  12. The paracaspase MALT1 in psoriasis
  13. The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function
  14. Quantifying salt sensitivity
  15. Life sciences and mass spectrometry: some personal reflections
https://doi.org/10.1515/hsz-2021-0249
Keywords for this article
cAMP; CREMα; ICER; interleukin 2; metabolism; Th17

Articles in the same Issue

  1. Frontmatter
  2. Highlight: Molecular Determinants of Health and Disease - 25th Anniversary of the InterdisciplinaryCenter Clinical Research Münster
  3. Molecular determinants of health and disease
  4. Role of the gut microbiota in airway immunity and host defense against respiratory infections
  5. Dynamic phospho-modification of viral proteins as a crucial regulatory layer of influenza A virus replication and innate immune responses
  6. Molecular mechanisms of vasculopathy and coagulopathy in COVID-19
  7. Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment
  8. Epitranscriptomic modifications in acute myeloid leukemia: m6A and 2′-O-methylation as targets for novel therapeutic strategies
  9. Molecular determinants of therapy response of venetoclax-based combinations in acute myeloid leukemia
  10. Pseudomonas aeruginosa and Staphylococcus aureus virulence factors as biomarkers of infection
  11. Controllers of cutaneous regulatory T cells: ultraviolet radiation and the skin microbiome
  12. The paracaspase MALT1 in psoriasis
  13. The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function
  14. Quantifying salt sensitivity
  15. Life sciences and mass spectrometry: some personal reflections
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