Platelets as a ‘natural factory’ for growth factor production that sustains normal (and pathological) cell biology
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Sheila Siqueira Andrade
, Alessandra Valéria de Sousa Faria
Abstract
Platelets have attracted substantial attention in the current decade owing to their unexpected pleiotropic properties and conflicted functions. In fact, platelets participate in both health (hemostasis) and disease (thrombotic diseases). Much of the plasticity of platelets comes from the fact that platelets are the reservoir and the ‘natural factory’ of growth factors (GFs), with pivotal functions in wound repair and tissue regeneration. By combining the platelets’ plasticity and biotechnological processes, PlateInnove Biotechnology optimized the production of GFs in nanoparticle biointerfacing by platelet content, which opens an avenue of possibilities.
Funding source: São Paulo Research Foundation
Award Identifier / Grant number: 2016/14459-3
Award Identifier / Grant number: 2017/26317-1
Funding statement: The authors would like to thank the support of Hemocentro de Campinas/UNICAMP, Colsan (Associação Beneficente de Coleta de Sangue), Hemocentro de Ribeirão Preto/USP, and the São Paulo Research Foundation (FAPESP) under grant 2016/14459-3 and 2017/26317-1.
Conflict of interest statement: Sheila Siqueira Andrade is the founder and Executive Director of PlateInnove Biotechnology, São Paulo, Brazil.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/hsz-2019-0342).
©2020 Walter de Gruyter GmbH, Berlin/Boston
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?
- Developments in anticancer vaccination: budding new adjuvants
- The cGMP system: components and function
- Minireview
- Platelets as a ‘natural factory’ for growth factor production that sustains normal (and pathological) cell biology
- Research Articles/Short Communications
- Genes And Nucleic Acids
- Hsa-miR-6165 downregulates insulin-like growth factor-1 receptor (IGF-1R) expression and enhances apoptosis in SW480 cells
- Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs
- Molecular Medicine
- Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome
- Cell Biology and Signaling
- Bone marrow-derived mesenchymal stem cells utilize the notch signaling pathway to induce apoptosis of hepatic stellate cells via NF-κB sensor
- Different signaling and functionality of Rac1 and Rac1b in the progression of lung adenocarcinoma