Abstract
Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), the two primary metabolic pathways for generating ATP. Impaired function of SDH results in deleterious disorders from cancer to neurodegeneration. SDH function is tailored to meet the energy demands in different cell types. Thus, understanding how SDH function is regulated and how it operates in distinct cell types can support the development of therapeutic approaches against the diseases. In this article we discuss the molecular pathways which regulate SDH function and describe extra roles played by SDH in specific cell types.
Funding source: National Key Research and Development Program of China
Award Identifier / Grant number: 2017YFD0200500
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: 21837001
Funding statement: Research on the biochemistry of SDH in the authors’ laboratories was supported by the National Key Research and Development Program of China (No. 2017YFD0200500) and the National Natural Science Foundation of China (No. 21837001). We acknowledge the help of Yan Aiming with drawing Figure 1.
References
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function
- Transport mechanism of Mycobacterium tuberculosis MmpL/S family proteins and implications in pharmaceutical targeting
- Research Articles/Short Communications
- Genes and Nucleic Acids
- LncRNA MALAT1 inhibits hypoxia/reoxygenation-induced human umbilical vein endothelial cell injury via targeting the microRNA-320a/RAC1 axis
- Protein Structure and Function
- Identification of new probe substrates for human CYP20A1
- Molecular Medicine
- Exosomal MALAT1 derived from ox-LDL-treated endothelial cells induce neutrophil extracellular traps to aggravate atherosclerosis
- Cell Biology and Signaling
- Derlin-1 functions as a growth promoter in breast cancer
- Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting
- Long noncoding RNA Linc01296 promotes hepatocellular carcinoma development through regulation of the miR-26a/PTEN axis
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function
- Transport mechanism of Mycobacterium tuberculosis MmpL/S family proteins and implications in pharmaceutical targeting
- Research Articles/Short Communications
- Genes and Nucleic Acids
- LncRNA MALAT1 inhibits hypoxia/reoxygenation-induced human umbilical vein endothelial cell injury via targeting the microRNA-320a/RAC1 axis
- Protein Structure and Function
- Identification of new probe substrates for human CYP20A1
- Molecular Medicine
- Exosomal MALAT1 derived from ox-LDL-treated endothelial cells induce neutrophil extracellular traps to aggravate atherosclerosis
- Cell Biology and Signaling
- Derlin-1 functions as a growth promoter in breast cancer
- Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting
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