Abstract
Epithelial ovarian cancer (EOC) is the most common and deadly ovarian cancer. Most of the patients have abdominal/pelvic invasion and metastasis at the time of diagnosis, but the underlying mechanism remains unclear. Insufficiency of blood perfusion and diffusion within most solid tumors can lead to a hypoxic tumor microenvironment and promotes tumor malignancy. In the present study, we detected the role of the spermatogenesis- and oogenesis-specific basic helix-loop-helix (bHLH) transcription factor 2 (sohlh2) on migration, invasion and epithelial-mesenchymal transition (EMT) of EOC cell lines under hypoxia in vitro. We also investigated the possible mechanism underlying it. The results showed that sohlh2 inhibited the migration, invasion and EMT of EOC cells and might function through suppression of the hypoxia-inducible factor 1α (HIF1α)/carbonic anhydrase 9 (CA9) signaling pathway. Our results may open a new avenue for the further development of diagnostic tools and novel therapeutics that will benefit EOC patients.
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: 81672861
Award Identifier / Grant number: 81874118
Funding source: The Shandong Department of Science and Technology Plan Project
Award Identifier / Grant number: 2019GSF107013
Award Identifier / Grant number: 2017GSF218029
Funding source: Natural Science Foundation of Shandong Province
Award Identifier / Grant number: ZR2014HM017
Award Identifier / Grant number: ZR2016HM79
Award Identifier / Grant number: ZR201702180317
Award Identifier / Grant number: ZR2014HM035
Funding statement: This work was supported by the National Natural Science Foundation of China under Grant numbers 81672861 and 81874118, The Shandong Department of Science and Technology Plan Project under Grant numbers 2019GSF107013 and 2017GSF218029, and the Natural Science Foundation of Shandong Province under Grant numbers ZR2014HM017, ZR2016HM79, ZR201702180317 and ZR2014HM035.
Conflict of interest statement: The authors declare no conflict of interest.
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©2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Cysteine, glutathione and a new genetic code: biochemical adaptations of the primordial cells that spread into open water and survived biospheric oxygenation
- What you see is what you get: activity-based probes in single-cell analysis of enzymatic activities
- Research Articles/Short Communications
- Protein Structure and Function
- Evolution, purification, and characterization of RC0497: a peptidoglycan amidase from the prototypical spotted fever species Rickettsia conorii
- Cell Biology and Signaling
- Sohlh2 alleviates malignancy of EOC cells under hypoxia via inhibiting the HIF1α/CA9 signaling pathway
- Thioredoxin inhibitor PX-12 induces mitochondria-mediated apoptosis in acute lymphoblastic leukemia cells
- TMEM100 expression suppresses metastasis and enhances sensitivity to chemotherapy in gastric cancer
- Inhibitory effect of activin A on IL-9 production by mouse NK cells through Smad3 signaling
- Intracellular distribution of pseudorabies virus UL2 and detection of its nuclear import mechanism
Articles in the same Issue
- Frontmatter
- Reviews
- Cysteine, glutathione and a new genetic code: biochemical adaptations of the primordial cells that spread into open water and survived biospheric oxygenation
- What you see is what you get: activity-based probes in single-cell analysis of enzymatic activities
- Research Articles/Short Communications
- Protein Structure and Function
- Evolution, purification, and characterization of RC0497: a peptidoglycan amidase from the prototypical spotted fever species Rickettsia conorii
- Cell Biology and Signaling
- Sohlh2 alleviates malignancy of EOC cells under hypoxia via inhibiting the HIF1α/CA9 signaling pathway
- Thioredoxin inhibitor PX-12 induces mitochondria-mediated apoptosis in acute lymphoblastic leukemia cells
- TMEM100 expression suppresses metastasis and enhances sensitivity to chemotherapy in gastric cancer
- Inhibitory effect of activin A on IL-9 production by mouse NK cells through Smad3 signaling
- Intracellular distribution of pseudorabies virus UL2 and detection of its nuclear import mechanism