Association between vitamin D level and prognostic factors among patients infected with SARS-CoV-2

Mehrdad Haghighi; Seyed Shayan Ebadi; Hussein Soleimantabar; Atefe Shadkam; Seyed Alireza Ebadi; Hasan Afzali

doi:10.1515/hmbci-2021-0008

Article

Association between vitamin D level and prognostic factors among patients infected with SARS-CoV-2

Mehrdad Haghighi , Seyed Shayan Ebadi , Hussein Soleimantabar , Atefe Shadkam , Seyed Alireza Ebadi and Hasan Afzali

Published/Copyright: May 19, 2021

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From the journal Hormone Molecular Biology and Clinical Investigation Volume 42 Issue 4

Abstract

Objectives

The present study aimed to evaluate the presence of any relationship between vitamin D and prognostic factors among patients infected with SARS-CoV-2.

Methods

This retrospective cross-sectional study was conducted among patients admitted from March to August 2020 in a referral hospital, Tehran, Iran. All patients aged 18–65 who had not any comorbidity participated in the study. The diagnosis of COVID-19 was established using the rRT-PCR test for SARS-CoV-2 detection. Then the incidence of lung involvement and biochemical markers including vitamin D level, c-reactive protein, D-dimer, lymphocyte count, platelet count, white blood cell count, and lactic acid dehydrogenase, were extracted through medical records.

Results

Altogether, 84 patients met our study criteria, and the information of 68 (80.9%) participants were collected. Among all 68 patients, 45 (66.2%) were male. The mean (SD) age of all participants was 52.4 (10.4) years old. Among 24 (35.2%) clients who died due to SARS-CoV-2, 20 (83.3%) patients were male (p=0.02). The mean (SD) of vitamin D level was 24.1 (13.6) ng/dL. No association between vitamin D level and prognostic factors, including CRP, lymphocyte count, D-dimer, LDH, and HRCT scan score, was observed. Also, the vitamin D level of the dead patients was not significantly different from that of the treated patients.

Conclusions

Our findings indicated no significant relationship between vitamin D level and prognostic factors or outcomes of patients infected with SARS-CoV-2.

Keywords: COVID-19; HRCT scan; lymphocyte count; prognosis; SARS-CoV-2

Corresponding author: Seyed Alireza Ebadi, Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Internal Medicine Ward, Imam Hossein Hospital, Madani St, 1617763141 Tehran, Iran, E-mail: sa.ebadi@sbmu.ac.ir

Funding source: Clinical Research Development Research Center

Acknowledgments

This study was supported by Clinical Research Development Research Center (CRDCR) of Imam Hossein hospital, Tehran, Iran. Moreover, the authors would express their profound gratitude to Dr. Shahin Salehi and Ms. Haghighi for their valuable contribution.

Research funding: This study was funded by CRDCR of Imam Hossein hospital, Tehran, Iran.
Author contributions: Mehrdad Haghighi: Conceptualization, Funding acquisition, Methodology, Project administration, Visualization, Writing – review & editing; Seyed Shayan Ebadi: Conceptualization, Data curation, Formal analysis, Project administration, Investigation, Validation, Writing – original draft; Hussein Soleimantabar: Data curation, Investigation, Methodology, Resources, Visualization; Atefe Shadkam: Data curation, Investigation, Methodology, Resources, Visualization; Seyed Alireza Ebadi: Concept-ualization, Project administration, Supervision, writing – review & editing. Hasan Afzali: Conceptualization, Methodology, Visualization.
Competing interests: There was not conflict of financial or other interest among the authors.
Informed consent: All information and identity of the participants remained confidential. Moreover, informed consent was obtained from eligible participants at the beginning of the study.
Ethical approval: The present study was approved by the ethics committee of Shahid Beheshti University of Medical Sciences (SBMU) with a reference number of (IR.SBMU.RETECH.REC.1399.940).

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Received: 2021-01-30

Accepted: 2021-04-08

Published Online: 2021-05-19

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Articles in the same Issue

https://doi.org/10.1515/hmbci-2021-0008

Keywords for this article

COVID-19; HRCT scan; lymphocyte count; prognosis; SARS-CoV-2