Distant recurrence of endometrial cancer more than 10 years after hysterectomy: a case report

Boom Ping Khoo; Kah Teik Chew; Erica Yee Hing; Nirmala Kampan; Mohamad Nasir Shafiee

doi:10.1515/hmbci-2021-0025

Article

Distant recurrence of endometrial cancer more than 10 years after hysterectomy: a case report

Boom Ping Khoo , Kah Teik Chew , Erica Yee Hing , Nirmala Kampan and Mohamad Nasir Shafiee

Published/Copyright: August 10, 2021

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From the journal Hormone Molecular Biology and Clinical Investigation Volume 42 Issue 4

Abstract

Objectives

Endometrial cancer is the sixth most common cancer among women and recurrence of after 10 years is extremely rare.

Case presentation

We reported a comprehensive review of histopathology, investigations and treatment regarding a woman with distant recurrence of endometrial cancer to rectus abdominis muscle after 23 years from the primary surgery. Previous published literatures of similar case were included into the review analysis. A total of 11 similar cases had been reported. Overall, 9 (81.8%) cases were stage 1 disease and only 2 cases were classified as stage II disease. The majority, 6 (54.5%) cases were endometrial adenocarcinoma. Majority of the cases shared the similarity of low grade endometrial cancer with positive oestrogen receptor immunophynetype.

Conclusions

Thus, the phenomenon of ‘cell dormancy’ was hypothesized to explain the mechanism of late recurrence for these cases.

Keywords: carcinoma; cell dormant; endometrial cancer; late recurrence; recurrence; relapse

Corresponding author: Kah Teik Chew, Department of Obstetrics and Gynaecology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia, Phone: +60391455958, E-mail: drchewkt@gmail.com

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Conflicts of Interest: The authors declare no conflict of interest. All authors are responsible for the content and writing of this paper.
Informed consent: Informed consent was obtained from individual included in this study.
Ethical approval: The local Institutional Review Board deemed the study exempt from review.

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Received: 2021-03-16

Accepted: 2021-07-06

Published Online: 2021-08-10

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Articles in the same Issue

https://doi.org/10.1515/hmbci-2021-0025

Keywords for this article

carcinoma; cell dormant; endometrial cancer; late recurrence; recurrence; relapse