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Investigation of the effect of training on serotonin, melatonin and hematologic parameters in adolescent basketball players

  • Sayad Kocahan EMAIL logo , Aykut Dundar , Muhittin Onderci and Yucehan Yilmaz
Published/Copyright: June 7, 2021
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Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 42 Issue 4

Abstract

Objectives

Exercise can improve both health and mood. Some beneficial effects of exercise are attributed to endocrine status. This study aims to evaluate the effect of eight weeks of basketball training on melatonin, serotonin, and hematologic parameters in basketball players.

Methods

The experimental group was selected form 34 healthy young boys, aged between 13 and 16 years old. The participants were randomly assigned to the control group (n=17) and the exercise group (n=17). The exercise program consisted of 2 h/day aerobic activity of basketball training in 5 days a week for 8 weeks. Venous blood was taken on the day before experiment (pre-exercise) and on the day following the last exercise (post-exercise) and hormone levels were detected by ELISA.

Results

Serotonin and melatonin levels significantly increased in the post-exercise group compared to the other groups (p<0.05). Exercise caused increase in WBC, RBC, HCT and Hb levels (p<0.05) while did not alter PLT, MCH, and PCT levels (p>0.05). This study indicates that an eight weeks-long regular aerobic exercise increased melatonin and serotonin levels, and also altered some hematological parameters.

Conclusions

In conclusion, it is believed that improvement in levels of serotonin, melatonin, and hematological parameters after eight weeks of regular basketball training in basketball players could be attributed to beneficial effects of exercise. Investigation in other branches of sports and in different gender and age groups would make contribution into exercise physiology and training science.

Keywords: exercise; hematologic parameters; melatonin; serotonin
Corresponding author: Sayad Kocahan, Department of Physiology, Faculty of Medicine, University of Adiyaman, Adiyaman, Turkey; and International Scientific Center, Baku State University, Baku, Azerbaijan, Phone: +90 535 630 2177, E-mail:

Acknowledgments

The authors thank the participants for their voluntary participation in this study.

  1. Research funding: The authors state that no funding was involved.

  2. Author contributions: We confirm that the authors whose names are included in this article (SK, AD, MO and YY.) Have made equal and significant contributions to the understanding of this study, have read and revised this article critically and approved the final draft. It is responsible for the content and publication of the manuscript.

  3. Competing interests: The authors declare that they have no conflict of interest.

  4. Informed consent: Written informed consent was obtained from the participants and their parents before the study.

  5. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its subsequent amendments. (Non-İnterventional Clinical Research Ethics Committee, Adiyaman University Approval Number: 2017/7-1).

References

1. Hackney, AC. Exercise as a stressor to the human neuroendocrine system. Medicina (Kaunas) 2006;42:788–97.Search in Google Scholar

2. Hackney, AC. Stress and the neuroendocrine system: the role of exercise as a stressor and modifier of stress. Expet Rev Endocrinol Metabol 2006;1:783–92. https://doi.org/10.1586/17446651.1.6.783.Search in Google Scholar PubMed PubMed Central

3. Lin, TW, Kuo, YM. Exercise benefits brain function: the monoamine connection. Brain Sci 2013;11:39–53. https://doi.org/10.3390/brainsci3010039.Search in Google Scholar PubMed PubMed Central

4. Patrick, RP, Ames, BN. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. FASEB J 2015;29:2207–22. https://doi.org/10.1096/fj.14-268342.Search in Google Scholar PubMed

5. Clark, A, Mach, N. Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes. J Int Soc Sports Nut 2016;13:43. https://doi.org/10.1186/s12970-016-0155-6.Search in Google Scholar PubMed PubMed Central

6. Murakami, S, Imbe, H, Morikawa, Y, Kubo, C, Senba, E. Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly. Neurosci Res 2005;53:129–39. https://doi.org/10.1016/j.neures.2005.06.008.Search in Google Scholar PubMed

7. Hong, Y, Palaksha, KJ, Park, K, Park, S, Kim, HD, Reiter, RL, et al.. Melatonin plus exercise‐based neurorehabilitative therapy for spinal cord injury. J Pineal Res 2010;49:201–9. https://doi.org/10.1111/j.1600-079x.2010.00786.x.Search in Google Scholar

8. Rodriquez, C, Mayo, JC, Sainz, RJ, Antolin, I, Herrera, F, Martin, V, et al.. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004;36:1–9.10.1046/j.1600-079X.2003.00092.xSearch in Google Scholar

9. Reiter, RJ, Tan, DX, Gitto, E, Sainz, RM, Mayo, JC, Leon, J, et al.. Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage. Pol J Pharmacol 2004;56:159–70.Search in Google Scholar

10. Escames, G, Ozturk, G, Bano-Otalora, B, Pozo, MJ, Madrid, JA, Reiter, RJ, et al.. Exercise and melatonin in humans: reciprocal benefits. J Pineal Res 2012;52:1–11. https://doi.org/10.1111/j.1600-079x.2011.00924.x.Search in Google Scholar

11. Mcmurray, RG, Forsythe, WA, Mar, MH, Hardy, CJ. Exercise intensity-related responses of beta-endorphin and catecholamines. Med Sci Sports Exerc 1987;19:570–4. https://doi.org/10.1249/00005768-198712000-00005.Search in Google Scholar

12. Fraschini, F, Stankov, B. High affinity melatonin receptors in the vertebrate brain: implications for the control of the endogenous oscillatory systems. Chronobiologia 1994;21:89–92.Search in Google Scholar

13. Buxton, OM, Hermite-Balerlaux, ML, Hirschfeld, U, Cauter, EV. Acute and delayed effects of exercise on human melatonin secretion. J Biol Rhythms 1997;12:568–74. https://doi.org/10.1177/074873049701200611.Search in Google Scholar PubMed

14. Buxton, OM, Lee, CW, LHermite-Baleriaux, M, Turek, FW, Van Cauter, E. Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase. Am J Physiol Regul Integr Comp Physiol 2003;284:714–24. https://doi.org/10.1152/ajpregu.00355.2002.Search in Google Scholar PubMed

15. Cheikh, M, Makhlouf, K, Ghattassi, K, Graja, A, Ferchichi, S, Kallel, C, et al.. Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation during intense short term effort in the following day in teenage athletes. Chronobiol Int 2020;37:236–47. https://doi.org/10.1080/07420528.2019.1692348.Search in Google Scholar PubMed

16. Escames, G, Ozturk, G, Baño‐Otálora, B, Pozo, MJ, Madrid, JA, Reiter, RJ, et al.. Exercise and melatonin in humans: reciprocal benefits. J Pineal Res 2012;52:1–11. https://doi.org/10.1111/j.1600-079x.2011.00924.x.Search in Google Scholar PubMed

17. Dundar, A, Kocahan, S, Arslan, C. Effects of different loading exercises on apelin levels and physical and hematologic parameters of swimmers. Horm Mol Biol Clin Invest 2019;38:20180070. https://doi.org/10.1515/hmbci-2018-0070 Search in Google Scholar PubMed

18. Cinar, V, Nizamlioglu, M, Mogulkoc, R, Baltaci, AK. Effects of magnesium supplementation on blood parameters of athletes at rest and after exercise. Biol Trace Elem Res 2007;115:205–12. https://doi.org/10.1007/s12011-007-9000-8.Search in Google Scholar

19. Cinar, V, Mogulkoc, R, Baltaci, AK. Calcium supplementation and 4-week exercise on blood parameters of athletes at rest and exhaustion. Biol Trace Elem Res 2010;134:130–5. https://doi.org/10.1007/s12011-009-8459-x.Search in Google Scholar PubMed

20. Hazratian, MR, Taheri Chadorneshin, H, Rashidi, A. The effect of one bout of intensive judo exercise on select hematological and immunological parameters in adolescent elite Judo athletes. Asian J Sports Med 2020;11:e101364. https://doi.org/10.5812/asjsm.101364.Search in Google Scholar

21. Yalcin, O, Erman, A, Muratli, S, Bor-Kucukatay, M, Baskurt, OK. Time course of hemorheological alterations after heavy anaerobic exercise in untrained human subjects. J Appl Physiol 2003;94:997–1002. https://doi.org/10.1152/japplphysiol.00368.2002.Search in Google Scholar PubMed

22. Demirhan, B, Günay, M, Canuzakov, K, Kılıç, M, Güzelbektes, H, Patlar, S. Seasonal evaluation of skeletal muscle damage and hematological and biochemical parameters of Greco-Roman wrestlers from the Kyrgyzstan National Team before the 2016 Summer Olympic Games. J Back Musculoskelet Rehabil 2020;33:701–9. https://doi.org/10.3233/BMR-181363.Search in Google Scholar PubMed

23. Bhatti, R, Shaikh, DM. The effect of exercise on blood parameters. Pak J Physiol 2007;3:12–31.Search in Google Scholar

24. Cerqueira, É, Marinho, DA, Neiva, HP, Lourenço, O. Inflammatory effects of high and moderate intensity exercise – a systematic review. Front Physiol 2020;10:1550. https://doi.org/10.3389/fphys.2019.01550.Search in Google Scholar PubMed PubMed Central

25. Nader, E, Guillot, N, Lavorel, L, Hancco, I, Fort, R, Stauffer, E, et al.. Eryptosis and hemorheological responses to maximal exercise in athletes: comparison between running and cycling. Scand J Med Sci Sports 2018;28:1532–40. https://doi.org/10.1111/sms.13059.Search in Google Scholar

26. Wardyn, GG, Rennard, SI, Brusnahan, SK, McGuire, TR, Carlson, ML, Smith, LM, et al.. Effects of exercise on hematological parameters, circulating side population cells, and cytokines. Exp Hematol 2008;36:216–23. https://doi.org/10.1016/j.exphem.2007.10.003.Search in Google Scholar

27. Kocahan, S, Dundar, A. Effects of different exercise loads on the thyroid hormone levels and serum lipid profile in swimmers. Horm Mol Biol Clin Invest 2018;38:20180025. https://doi.org/10.1515/hmbci-2018-0025.Search in Google Scholar

28. Heijnen, S, Hommel, B, Kibele, A, Colzato, LS. Neuromodulation of aerobic exercise—a review. Front Psychol 2016;6:1890. https://doi.org/10.3389/fpsyg.2015.01890.Search in Google Scholar

29. Yüksel, O, Akkoyunlu, Y, Karavelioğlu, MB, Harmancı, H, Kayhan, M, Koç, H. Basketbolcularda Core Alt Ekstremite Kuvveti Antrenmanlarının Dinamik Denge ve Şut İsabeti Üzerine Etkisi. Marmara Üniversitesi Spor Bilimleri Dergisi 2016;1:51–61. https://doi.org/10.22396/sbd.2016.5.Search in Google Scholar

30. Dundar, A, Kocahan, S, Sahin, L. Associations of apelin, leptin, irisin, ghrelin, insulin, glucose levels, and lipid parameters with physical activity during eight weeks of regular exercise training. Arch Physiol Biochem 2019;10:1–5 (Published online: 10 Jul 2019). https://doi.org/10.1080/13813455.2019.1635622.Search in Google Scholar

31. Harmer, CJ. Serotonin and emotional processing: does it help explain antidepressant drug action? Neuropharmacology 2008;55:1023–8. https://doi.org/10.1016/j.neuropharm.2008.06.036.Search in Google Scholar

32. Dey, S, Singh, RH, Dey, PK. Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise. Physiol Behav 1992;52:1095–9. https://doi.org/10.1016/0031-9384(92)90465-e.Search in Google Scholar

33. Chen, HI, Lin, LC, Yu, L, Huang, AM, Chuang, JI, Wu, FS, et al.. Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system. Neurobiol Learn Mem 2008;89:489–96. https://doi.org/10.1016/j.nlm.2007.08.004.Search in Google Scholar PubMed

34. Chennaoui, M, Grimaldi, B, Fillion, MP, Bonnin, A, Drogou, C, Fillion, G, et al.. Effects of physical training on functional activity of 5-HT1B receptors in rat central nervous system: role of 5-HT-moduline. Naunyn-Schmiedeberg’s Arch Pharmacol 2000;361:600–4. https://doi.org/10.1007/s002100000242.Search in Google Scholar PubMed

35. Melancon, MO, Lorrain, D, Dionne, IJ. Exercise and sleep in aging: emphasis on serotonin. Pathol Biol 2014;62:276–83. https://doi.org/10.1016/j.patbio.2014.07.004.Search in Google Scholar

36. Atkinson, G, Drust, B, Reilly, T, Walterhouse, J. The relevance of melatonin to sports medicine and science. Sports Med 2003;33:809–31. https://doi.org/10.2165/00007256-200333110-00003.Search in Google Scholar

37. Knight, JA, Thompson, S, Raboud, JM, Hoffman, BR. Light and exercise and melatonin production in women. Am J Epidemiol 2005;162:1114–22. https://doi.org/10.1093/aje/kwi327.Search in Google Scholar

38. Monteleone, P, Maj, M, Fusco, M, Orazzo, C, Kemal, D. Physical exercise at night blunts the nocturnal increase of plasma melatonin levels in healthy humans. Life Sci 1990;47:1989–95. https://doi.org/10.1016/0024-3205(90)90432-q.Search in Google Scholar

39. Monteleone, P, Maj, M, Fuschino, A, Kemali, D. Physical stress in the middle of the dark phase does not affect light-depressed plasma melatonin levels in humans. Neuroendocrinology 1992;55:367–71. https://doi.org/10.1159/000126146.Search in Google Scholar

40. Ronkainen, H, Vakkuri, O, Kauppila, A. Effects of physical exercise on the serum concentration of melatonin in female runners. Acta Obstet Gynecol Scand 1986;65:827–9. https://doi.org/10.3109/00016348609157031.Search in Google Scholar

41. Pobocik, KM, Rentzell, SAV, Leonard, AJ, Daye, AN, Evans, ES. Influence of aerobic exercise on sleep and salivary melatonin in men. Int J Sports Exerc Med 2020;6:161–7. https://doi.org/10.23937/2469-5718/6/1.Search in Google Scholar

42. Bodary, B, Pate, RR, Wu, Q, McMillian, GS. Effect of acute on plasma erythropoietin levels in trained runners. Med Sci Sport Exercl 1999;31:543–6. https://doi.org/10.1097/00005768-199904000-00008.Search in Google Scholar

43. Neumatr, G, Pfister, R, Mitterbauer, G, Gaenzer, H, Joannids, M, Eibl, G, et al.. Short-term effect of prolonged strenuous endurance exercise on the level of hematocrit in amateur cyclist. Int J Sports Med 2002;23:158–66. https://doi.org/10.1055/s-2002-23169.Search in Google Scholar

44. Chen, H, Tang, Y, Jen, CJ. Effect of acute exercise on bleeding time, bleeding amount, and blood cell counts: a comparative study. Thromb Res 1989;55:503–10. https://doi.org/10.1016/0049-3848(89)90058-3.Search in Google Scholar

45. De Scalzi, M, Cinelli, P, De Leonardis, V. Response of some haemacoagulatory and haemarheological variables to maximal exercise in sedentary and active subjects. J Int Med Res 1987;15:361–7. https://doi.org/10.1177/030006058701500605.Search in Google Scholar PubMed

46. Robson-Ansley, P, Barwood, M, Canavan, J, Hack, S, Eglin, C, Davey, S, et al.. The effect of repeated endurance exercise on IL-6 and sIL-6R and their relationship with sensations of fatigue at rest. Cytokine 2009;45:111–6. https://doi.org/10.1016/j.cyto.2008.11.006.Search in Google Scholar PubMed

47. Ahmadizad, S, Rahmani, H, Khosravi, N, Falakdin, Z, Connes, P, Daraei, A. Acute responses of platelet count and ADP-induced platelet aggregation to different high intensity interval exercise modes. Clin Hemorheol Microcirc 2020;75:1–8. https://doi.org/10.3233/CH-200848.Search in Google Scholar PubMed

48. Huang, WS, Yu, MD, Lee, MS, Cheng, CY, Yang, SP, Chin, HML, et al.. Effect of treadmill exercise on circulating thyroid hormone measurements. Med Princ Pract 2004;13:15–9. https://doi.org/10.1159/000074045.Search in Google Scholar PubMed

Received: 2020-12-18
Accepted: 2021-05-08
Published Online: 2021-06-07

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/hmbci-2020-0095
Keywords for this article
exercise; hematologic parameters; melatonin; serotonin

Articles in the same Issue

  1. Frontmatter
  2. Letters to the Editor
  3. The solution to obesity and type 2 diabetes: reversing insulin resistance
  4. The second wave of COVID-19: effect on Indian health care system
  5. Original Articles
  6. Association between vitamin D level and prognostic factors among patients infected with SARS-CoV-2
  7. The association between serum vitamin D and mood disorders in a cohort of lipedema patients
  8. Inhibition of PI3K/Akt and ERK signaling decreases visfatin-induced invasion in liver cancer cells
  9. The outcome of intra-cytoplasmic sperm injection (ICSI): do the sperm concentration and motility matter?
  10. Effect of two hypercaloric diets on the hormonal and metabolic profile of the adrenal gland
  11. Investigation of the effect of training on serotonin, melatonin and hematologic parameters in adolescent basketball players
  12. A fine tuning of embryo loading technique by eliminating the air bubble in the outer sheath of embryo catheter among women undergoing IVF treatment
  13. Effects of different doses of melatonin on rat adipose derived mesenchymal stem cells
  14. PTEN protein expression has role in predicting disease-free-interval in endometrioid endometrial carcinoma
  15. Amelioration of STZ-induced nephropathy in diabetic rats by saffron hydro alcoholic extract
  16. Elevated levels of neopterin and pentraxin 3 in patients with rheumatoid arthritis
  17. Case Reports
  18. COVID-19 transmission: a positive perspective
  19. Distant recurrence of endometrial cancer more than 10 years after hysterectomy: a case report
  20. Review Articles
  21. COVID-19 and lung pathologies
  22. Potential role of melatonin in prevention and treatment of leukaemia
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