Startseite Lebenswissenschaften Fertility preservation in borderline ovarian tumor patients and survivors
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Fertility preservation in borderline ovarian tumor patients and survivors

  • Marine Poulain EMAIL logo , Jessica Vandame , Chloé Tran , Sonia Koutchinsky , Paul Pirtea und Jean-Marc Ayoubi
Veröffentlicht/Copyright: 6. Juli 2020
Hormone Molecular Biology and Clinical Investigation
Aus der Zeitschrift Hormone Molecular Biology and Clinical Investigation Band 43 Heft 2

Abstract

Borderline ovarian tumors (BOTs) represent around 15% of all epithelial ovarian cancer. Around one third of those patients is under 40 and has not completed childbearing when the tumor is diagnosed. Cancer survivors are more and more concerned about their future fertility since a large proportion of those with BOTs are young. Whatever the tumor stage, information regarding future fertility after treatment and fertility preservation (FP) options must be delivered to all patients before treatment. A multidisciplinary team will discuss and propose personalized treatment and FP strategies. Nowadays, the FP options offered to patients with BOT are the followings: i) minimal invasive conservative surgery, ii) oocyte cryopreservation after controlled ovarian stimulation (COS) or in vitro maturation (IVM) and iii) ovarian tissue cryopreservation. Generally, the most common strategy to preserve future fertility is represented by minimal invasive conservative surgery. However, with the remarkable success and evolution of assisted reproductive technologies (ART) – notably progress and efficiency in COS and oocyte vitrification – have led to offer another potential approach for FP consisting in oocyte cryopreservation. Several COS protocols, such as random start or dual stimulation associating tamoxifen or aromatase inhibitors with gonadotropins provide similar results when compared to standard protocols while providing safety by minimizing the risk of high estrogen exposure. When COS is contraindicated, oocyte cryopreservation can still be possible throw IVM. Even though, oocyte competence after IVM is lower than that obtained after COS. A less used approach is cryopreservation of ovarian tissue, consisting in freezing ovarian cortex fragments for a future thawing and graft. Some concerns and limitations regard the ovarian cortex graft and the risk of reintroducing malignant cells once performed. Nonetheless, the latter it is the only option in prepubertal patients.

Keywords: borderline ovarian tumor; fertility preservation; fertility sparing surgery; oocyte cryopreservation; ovarian tissue cryopreservation
Corresponding author: Marine Poulain, Hôpital FOCH, Service de gynécologie obstétrique médicine de la reproduction, Unité de médicine de la reproduction, 40 rue Worth, 92150, Suresnes, France; and GIG-EA 7404, Université de Versailles-St Quentin, Université Paris-Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, 2 avenue de la Source de la Bièvre, F-78180, Montigny-le-Bretonneux, France, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission

  3. Competing interests: Authors have no conflict of interest

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

References

1. Bray, F, Ferlay, J, Soerjomataram, I, Siegel, RL, Torre, LA, Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394–424. https://doi.org/10.3322/caac.21492.Suche in Google Scholar

2. Morice, P, Uzan, C, Fauvet, R, Gouy, S, Duvillard, P, Darai, E. Borderline ovarian tumour: pathological diagnostic dilemma and risk factors for invasive or lethal recurrence. Lancet Oncol 2012 Mar;13:e103–15. https://doi.org/10.1016/s1470-2045(11)70288-1.Suche in Google Scholar

3. Hannibal, CG, Huusom, LD, Kjaerbye-Thygesen, A, Tabor, A, Kjaer, SK. Trends in incidence of borderline ovarian tumors in Denmark 1978-2006. Acta Obstet Gynecol Scand 2011 Apr;90:305–12.e. https://doi.org/10.1111/j.1600-0412.2010.01060.x.Suche in Google Scholar PubMed

4. Skírnisdóttir, I, Garmo, H, Wilander, E, Holmberg, L. Borderline ovarian tumors in Sweden 1960–2005: Trends in incidence and age at diagnosis compared to ovarian cancer. International Journal of Cancer 2008;123:1897–901. https://doi.org/10.1002/ijc.23724.Suche in Google Scholar PubMed

5. Yahata, T, Banzai, C, Tanaka, K. Niigata Gynecological Cancer Registry. Histology-specific long-term trends in the incidence of ovarian cancer and borderline tumor in Japanese females: a population-based study from 1983 to 2007 in Niigata. J Obstet Gynaecol Res 2012;38:645–50. https://doi.org/10.1111/j.1447-0756.2011.01755.x.Suche in Google Scholar PubMed

6. Schuurman, MS, Timmermans, M, van Gorp, T, de Vijver, KKV, Kruitwagen, RFPM, Lemmens, VEPP, Trends in incidence, treatment and survival of borderline ovarian tumors in the Netherlands: a nationwide analysis. Acta Oncologica 2019 Jul 3;58:983–9. https://doi.org/10.1080/0284186x.2019.1619935.Suche in Google Scholar PubMed

7. Bhatla, N, Denny, L. FIGO Cancer Report 2018. Int J Gynaecol Obstet 2018;143 (2 Suppl):S2–3. https://doi.org/10.1002/ijgo.12608.Suche in Google Scholar PubMed

8. Zanetta, G, Rota, S, Chiari, S, Bonazzi, C, Bratina, G, Mangioni, C. Behavior of borderline tumors with particular interest to persistence, recurrence, and progression to invasive carcinoma: a prospective study. J Clin Oncol 2001 May 15;19:2658–64. https://doi.org/10.1200/jco.2001.19.10.2658.Suche in Google Scholar

9. Green, AE, Garcia, AA, Ahmed, S. Ovarian cancer: practice essentials, background. Pathophysiology 2019 Nov 22. Available from: https://emedicine.medscape.com/article/255771-overview [Accessed27 Nov 2019].Suche in Google Scholar

10. Broekmans, FJ, Soules, MR, Fauser, BC. Ovarian aging: mechanisms and clinical consequences. Endocr Rev 2009 Aug;30:465–93. https://doi.org/10.1210/er.2009-0006.Suche in Google Scholar PubMed

11. Daraï, E, Fauvet, R, Uzan, C, Gouy, S, Duvillard, P, Morice, P. Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options. Hum Reprod Update 2013 Apr;19:151–66. https://doi.org/10.1093/humupd/dms047.Suche in Google Scholar PubMed

12. Song, T, Hun Choi, C, Lee, YY, Kim, TJ, Lee, JW, Bae, DS, et al. Oncologic and reproductive outcomes of cystectomy compared with oophorectomy as a treatment for borderline ovarian tumours. Hum Reprod 2011 Aug;26:2008–14. https://doi.org/10.3410/f.1158859.619255.Suche in Google Scholar

13. Candotti, G, Peiretti, M, Mangili, G, Bergamini, A, Candiani, M, Cioffi, R, et al. What women want: fertility sparing surgery in borderline ovarian tumours patients and pregnancy outcome. Eur J Surg Oncol 2019 Nov;46:888–92. https://doi.org/10.1016/j.ejso.2019.11.001.Suche in Google Scholar PubMed

14. Gershenson, DM. Management of borderline ovarian tumours. Best Pract Res Clin Obstet Gynaecol 2017 May;41:49–59. https://doi.org/10.1016/j.bpobgyn.2016.09.012.Suche in Google Scholar PubMed

15. Rousset-Jablonski, C, Selle, F, Adda-Herzog, E, Planchamp, F, Selleret, L, Pomel, C, et al. Fertility preservation, contraception and menopause hormone therapy in women treated for rare ovarian tumours: guidelines from the French national network dedicated to rare gynaecological cancers. Eur J Cancer 2019 Jul;116:35–44. https://doi.org/10.1016/j.ejca.2019.04.018.Suche in Google Scholar PubMed

16. Song, T, Choi, CH, Kim, HJ, Lee, W, Lee, YY, Kim, TJ, et al. Oncologic and reproductive outcomes in patients with advanced-stage borderline ovarian tumors. Eur J Obstet Gynecol Reprod Biol 2011 Jun;156:204–8. https://doi.org/10.1016/j.ejogrb.2011.01.009.Suche in Google Scholar PubMed

17. Angarita, AM, Johnson, CA, Fader, AN, Christianson, MS. Fertility preservation: a key survivorship issue for young women with cancer. Front Oncol 2016;6:102. https://doi.org/10.3389/fonc.2016.00102.Suche in Google Scholar PubMed PubMed Central

18. Oktay, K, Harvey, BE, Partridge, AH, Quinn, GP, Reinecke, J, Taylor, HS, et al. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol 2018 01;36:1994–2001. https://doi.org/10.1200/jco.2018.78.1914.Suche in Google Scholar

19. Baysal, Ö, Bastings, L, Beerendonk, CCM, Postma, SaE, IntHout, J, Verhaak, CM, et al. Decision-making in female fertility preservation is balancing the expected burden of fertility preservation treatment and the wish to conceive. Hum Reprod 2015 Jul;30:1625–34. https://doi.org/10.1093/humrep/dev116.Suche in Google Scholar

20. Stensheim, H, Cvancarova, M, Møller, B, Fosså, SD. Pregnancy after adolescent and adult cancer: a population-based matched cohort study. Int J Cancer 2011 Sep 1;129:1225–36. https://doi.org/10.1002/ijc.26045.Suche in Google Scholar

21. Johnson, J-A, Tough, S, SOGC GENETICS COMMITTEE. Delayed child-bearing. J Obstet Gynaecol Can 2012 Jan;34:80–93.10.1016/S1701-2163(16)35138-6Suche in Google Scholar

22. Siddiqui, QUA, Anjum, S, Zahra, F, Yousuf, SM. Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients. Pak J Med Sci 2019 Aug;35:958–62. https://doi.org/10.12669/pjms.35.4.753.Suche in Google Scholar PubMed PubMed Central

23. Asada, Y, Tsuiki, M, Sonohara, M, Fukunaga, N, Hattori, Y, Inoue, D, et al. Performance of anti-Müllerian hormone (AMH) levels measured by Beckman Coulter Access AMH assay to predict oocyte yield following controlled ovarian stimulation for in vitro fertilization. Reprod Med Biol 2019 Jul;18:273–7. https://doi.org/10.1002/rmb2.12271.Suche in Google Scholar PubMed PubMed Central

24. Sermondade, N, Sonigo, C, Sifer, C, Valtat, S, Ziol, M, Eustache, F, et al. Serum antimüllerian hormone is associated with the number of oocytes matured in vitro and with primordial follicle density in candidates for fertility preservation. Fertil Steril 2019;111:357–62. https://doi.org/10.1016/j.fertnstert.2018.10.018.Suche in Google Scholar PubMed

25. Donnez, J, Dolmans, M-M. Fertility preservation in women. N Engl J Med 2017 Oct-26;377:1657–65. https://doi.org/10.1056/NEJMra161467.Suche in Google Scholar

26. Peccatori, FA, Azim, HA, Orecchia, R, Hoekstra, HJ, Pavlidis, N, Kesic, V, et al. ESMO Guidelines Working Group. Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013 Oct;24 (6 Suppl):vi160–170.10.1093/annonc/mdt199Suche in Google Scholar PubMed

27. Kort, JD, Eisenberg, ML, Millheiser, LS, Westphal, LM. Fertility issues in cancer survivorship. CA Cancer J Clin 2014 Apr;64:118–34. https://doi.org/10.3322/caac.21205.Suche in Google Scholar PubMed

28. Hershberger, PE, Finnegan, L, Pierce, PF, Scoccia, B. The decision-making process of young adult women with cancer who considered fertility cryopreservation. J Obstet Gynecol Neonatal Nurs 2013 Feb;42:59–69. https://doi.org/10.1111/j.1552-6909.2012.01426.x.Suche in Google Scholar PubMed PubMed Central

29. Letourneau, JM, Ebbel, EE, Katz, PP, Katz, A, Ai, WZ, Chien, AJ, et al. Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer. Cancer 2012 Mar 15;118:1710–7. https://doi.org/10.1002/cncr.26459.Suche in Google Scholar

30. Trèves, R, Grynberg, M, le Parco, S, Finet, A, Poulain, M, Fanchin, R. Female fertility preservation in cancer patients: an instrumental tool for the envisioning a postdisease life. Future Oncol 2014 May;10:969–74. https://doi.org/10.2217/fon.13.265.Suche in Google Scholar

31. Morice, P, Camatte, S, El Hassan, J, Pautier, P, Duvillard, P, Castaigne, D. Clinical outcomes and fertility after conservative treatment of ovarian borderline tumors. Fertil Steril 2001 Jan;75:92–6. https://doi.org/10.1016/s0015-0282(00)01633-2.Suche in Google Scholar

32. Nayyar, N, Lakhwani, P, Goel, A, Pande, PK, Kumar, K. Management of borderline ovarian tumors-still a gray zone. Indian J Surg Oncol 2017 Dec;8:607–14. https://doi.org/10.1007/s13193-017-0697-3.Suche in Google Scholar PubMed PubMed Central

33. Sun, H, Chen, X, Zhu, T, Liu, N, Yu, A, Wang, S. Age-dependent difference in impact of fertility preserving surgery on disease-specific survival in women with stage I borderline ovarian tumors. J Ovarian Res 2018 Jun 29;11:54. https://doi.org/10.1186/s13048-018-0423-y.Suche in Google Scholar PubMed PubMed Central

34. Frega, A, Coluccia, AC, Di Martino, G, Catalano, A, Milazzo, GN, Assorgi, C, et al. Borderline ovarian tumors, fertility-sparing surgery and pregnancy outcome. Eur Rev Med Pharmacol Sci 2014;18:281–4.Suche in Google Scholar

35. Zhao, J, Liu, C, Liu, J, Qu, P. Short-term outcomes and pregnancy rate after laparoscopic fertility-sparing surgery for borderline ovarian tumors: a single-institute experience. Int J Gynecol Cancer 2018;28:274–8. https://doi.org/10.1097/igc.0000000000001170.Suche in Google Scholar PubMed PubMed Central

36. Kajiyama, H, Suzuki, S, Niimi, K, Tamauchi, S, Kawai, M, Nagasaka, T, et al. Oncologic and reproductive outcomes of cystectomy as a fertility-sparing treatment for early-stage epithelial ovarian cancer. Int J Clin Oncol 2019 Jul;24:857–62. https://doi.org/10.1007/s10147-019-01416-y.Suche in Google Scholar PubMed

37. Bjelland, EK, Wilkosz, P, Tanbo, TG, Eskild, A. Is unilateral oophorectomy associated with age at menopause? A population study (the HUNT2 Survey). Hum Reprod 2014 Apr;29:835–41. https://doi.org/10.1093/humrep/deu026.Suche in Google Scholar PubMed

38. Younis, JS, Naoum, I, Salem, N, Perlitz, Y, Izhaki, I. The impact of unilateral oophorectomy on ovarian reserve in assisted reproduction: a systematic review and meta-analysis. BJOG 2018 Jan;125:26–35. https://doi.org/10.1111/1471-0528.14913.Suche in Google Scholar PubMed

39. Uzan, C, Muller, E, Kane, A, Rey, A, Gouy, S, Bendiffallah, S, et al. Prognostic factors for recurrence after conservative treatment in a series of 119 patients with stage I serous borderline tumors of the ovary. Ann Oncol 2014 Jan;25:166–71. https://doi.org/10.1093/annonc/mdt430.Suche in Google Scholar PubMed

40. Vasconcelos, I, de Sousa Mendes, M. Conservative surgery in ovarian borderline tumours: a meta-analysis with emphasis on recurrence risk. Eur J Cancer 2015 Mar;51:620–31. https://doi.org/10.1016/j.ejca.2015.01.004.Suche in Google Scholar PubMed

41. Palomba, S, Zupi, E, Russo, T, Falbo, A, Del Negro, S, Manguso, F, et al. Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumours: a randomized controlled study. Hum Reprod 2007 Feb;22:578–85. https://doi.org/10.1093/humrep/del381.Suche in Google Scholar PubMed

42. Fauvet, R, Brzakowski, M, Morice, P, Resch, B, Marret, H, Graesslin, O, et al. Borderline ovarian tumors diagnosed during pregnancy exhibit a high incidence of aggressive features: results of a French multicenter study. Ann Oncol 2012 Jun;23:1481–7. https://doi.org/10.1093/annonc/mdr452.Suche in Google Scholar PubMed

43. Cosentino, F, Turco, LC, Cianci, S, Fanfani, F, Fagotti, A, Alletti, SG, et al. Management, prognosis and reproductive outcomes of borderline ovarian tumor relapse during pregnancy: from diagnosis to potential treatment options. J Prenat Med 2016;10:8–14. https://doi.org/10.11138/jpm/2016.10.1.008.Suche in Google Scholar

44. Fauvet, R, Poncelet, C, Boccara, J, Descamps, P, Fondrinier, E, Daraï, E. Fertility after conservative treatment for borderline ovarian tumors: a French multicenter study. Fertil Steril 2005 Feb;83:284–90.quiz 525–6. https://doi.org/10.1016/j.fertnstert.2004.10.009.Suche in Google Scholar

45. Gotlieb, WH, Flikker, S, Davidson, B, Korach, Y, Kopolovic, J, Ben-Baruch, G. Borderline tumors of the ovary: fertility treatment, conservative management, and pregnancy outcome. Cancer 1998 Jan 1;82:141–6.10.1002/(SICI)1097-0142(19980101)82:1<141::AID-CNCR17>3.0.CO;2-2Suche in Google Scholar

46. Rienzi, L, Gracia, C, Maggiulli, R, LaBarbera, AR, Kaser, DJ, Ubaldi, FM, et al. Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance. Hum Reprod Update 2017 01;23:139–55. https://doi.org/10.1093/humupd/dmw038.Suche in Google Scholar

47. Porcu, E, Venturoli, S, Damiano, G, Ciotti, PM, Notarangelo, L, Paradisi, R,et al. Healthy twins delivered after oocyte cryopreservation and bilateral ovariectomy for ovarian cancer. Reprod Biomed Online 2008 Aug;17:265–7. https://doi.org/10.1016/s1472-6483(10)60204-0.Suche in Google Scholar

48. Rizzuto, I, Behrens, RF, Smith, LA. Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility. Cochrane Database Syst Rev 2019 18;6:CD008215. https://doi.org/10.1002/14651858.CD008215.pub3.Suche in Google Scholar

49. Tropé, CG, Kaern, J, Davidson, B. Borderline ovarian tumours. Best Pract Res Clin Obstet Gynaecol 2012 Jun;26:325–36. https://doi.org/10.1016/j.bpobgyn.2011.12.006.Suche in Google Scholar

50. Pirtea, P, de Ziegler, D, Poulain, M, Ayoubi, JM. New twists in ovarian stimulation and their practical implications. Front Med (Lausanne) 2019;6:197. https://doi.org/10.3389/fmed.2019.00197.Suche in Google Scholar

51. Cakmak, H, Rosen, MP. Random-start ovarian stimulation in patients with cancer: Current Opinion in Obstetrics and Gynecology 2015 Jun;27:215–21. https://doi.org/10.1097/GCO.0000000000000180.Suche in Google Scholar

52. Nakasuji, T, Kawai, K, Ishikawa, T, Teraoka, K, Takeuchi, S, Miyagawa, T,et al. Random‐start ovarian stimulation with aromatase inhibitor for fertility preservation in women with Japanese breast cancer. Reprod Med Biol 2019 Apr;18:167–72. https://doi.org/10.1002/rmb2.12263.Suche in Google Scholar

53. Nayak, SR, Wakim, AN. Random-start gonadotropin-releasing hormone (GnRH) antagonist–treated cycles with GnRH agonist trigger for fertility preservation. Fertility and Sterility 2011Jul;96:e51–4. https://doi.org/10.1016/j.fertnstert.2011.04.079.Suche in Google Scholar

54. Boots, CE, Meister, M, Cooper, AR, Hardi, A, Jungheim, ES. Ovarian stimulation in the luteal phase: systematic review and meta-analysis. J Assist Reprod Genet 2016 Aug;33:971–80. https://doi.org/10.1007/s10815-016-0721-5.Suche in Google Scholar

55. Vaiarelli, A, Cimadomo, D, Trabucco, E, Vallefuoco, R, Buffo, L, Dusi, L,et al. Double stimulation in the same ovarian cycle (DuoStim) to maximize the number of oocytes retrieved from poor prognosis patients: a multicenter experience and SWOT analysis. Front Endocrinol 2018;9:317. https://doi.org/10.3389/fendo.2018.00317.Suche in Google Scholar

56. Tsampras, N, Gould, D, Fitzgerald, CT. Double ovarian stimulation (DuoStim) protocol for fertility preservation in female oncology patients. Hum Fertil (Camb) 2017 Dec;20:248–53https://doi.org/10.1080/14647273.2017.1287433.Suche in Google Scholar

57. Ubaldi, FM, Capalbo, A, Vaiarelli, A, Cimadomo, D, Colamaria, S, Alviggi, C,et al. Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation. Fertil Steril 2016 Jun;105:1488–1495.e1. https://doi.org/10.1016/j.fertnstert.2016.03.002.Suche in Google Scholar

58. Cobo, A, García-Velasco, JA, Coello, A, Domingo, J, Pellicer, A, Remohí, J. Oocyte vitrification as an efficient option for elective fertility preservation. Fertil Steril 2016 Mar;105:755–764.e8. https://doi.org/10.1016/j.fertnstert.2015.11.027.Suche in Google Scholar

59. Veeck, LL, Wortham, JW, Witmyer, J, Sandow, BA, Acosta, AA, Garcia, JE,et al. Maturation and fertilization of morphologically immature human oocytes in a program of in vitro fertilization. Fertil Steril 1983 May;39:594–602. https://doi.org/10.1016/s0015-0282(16)47052-4.Suche in Google Scholar

60. Cha, KY, Koo, JJ, Ko, JJ, Choi, DH, Han, SY, Yoon, TK. Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril 1991 Jan;55:109–13. https://doi.org/10.1016/s0015-0282(16)54068-0.Suche in Google Scholar

61. Hatırnaz, Ş, Ata, B, Hatırnaz, ES, Dahan, MH, Tannus, S, Tan, J, et al. Oocyte in vitro maturation: A sytematic review. Turk J Obstet Gynecol 2018;15:112–25. https://doi.org/10.4274/tjod.23911.Suche in Google Scholar PubMed PubMed Central

62. Moria, A, Das, M, Shehata, F, Holzer, H, Son, W-Y, Tulandi, T. Ovarian reserve and oocyte maturity in women with malignancy undergoing in vitro maturation treatment. Fertil Steril 2011Apr;95:1621–3. https://doi.org/10.1016/j.fertnstert.2010.12.041.Suche in Google Scholar PubMed

63. Fadini, R, Dal Canto, M, Mignini Renzini, M, Milani, R, Fruscio, R, Cantù, MG, et al. Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer. J Assist Reprod Genet 2012 Aug;29:779–81. https://doi.org/10.1007/s10815-012-9768-0.Suche in Google Scholar

64. Grynberg, M, Poulain, M, le Parco, S, Sifer, C, Fanchin, R, Frydman, N. Similar in vitro maturation rates of oocytes retrieved during the follicular or luteal phase offer flexible options for urgent fertility preservation in breast cancer patients. Hum Reprod 2016 Mar;31:623–9. https://doi.org/10.1093/humrep/dev325.Suche in Google Scholar

65. Park, CW, Lee, SH, Yang, KM, Lee, IH, Lim, KT, Lee, KH, et al. Cryopreservation of in vitro matured oocytes after ex vivo oocyte retrieval from gynecologic cancer patients undergoing radical surgery. Clin Exp Reprod Med 2016 Jun;43:119–25. https://doi.org/10.5653/cerm.2016.43.2.119.Suche in Google Scholar

66. Prasath, EB, Chan, MLH, Wong, WHW, Lim, CJW, Tharmalingam, MD, Hendricks, M, et al. First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient. Hum Reprod 2014 Feb;29:276–8. https://doi.org/10.1093/humrep/det420.Suche in Google Scholar

67. Segers, I, Mateizel, I, Van Moer, E, Smitz, J, Tournaye, H, Verheyen, G, et al. In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe. J Assist Reprod Genet 2015 Aug;32:1221–31. https://doi.org/10.1007/s10815-015-0528-9.Suche in Google Scholar

68. Sonigo, C, Simon, C, Boubaya, M, Benoit, A, Sifer, C, Sermondade, N, et al. What threshold values of antral follicle count and serum AMH levels should be considered for oocyte cryopreservation after in vitro maturation? Hum Reprod 2016;31:1493–500. https://doi.org/10.1093/humrep/dew102.Suche in Google Scholar

69. Luyckx, V, Durant, JF, Camboni, A, Gilliaux, S, Amorim, CA, Van Langendonckt, A, et al. Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study. J Assist Reprod Genet 2013 Oct;30:1289–99. https://doi.org/10.1007/s10815-013-0065-3.Suche in Google Scholar

70. Donnez, J, Dolmans, MM, Demylle, D, Jadoul, P, Pirard, C, Squifflet, J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet 2004 Oct 16;364:1405–10. https://doi.org/10.1016/s0140-6736(04)17222-x.Suche in Google Scholar

71. Van der Ven, H, Liebenthron, J, Beckmann, M, Toth, B, Korell, M, Krüssel, J,et al. Ninety-five orthotopic transplantations in 74 women of ovarian tissue after cytotoxic treatment in a fertility preservation network: tissue activity, pregnancy and delivery rates. Hum Reprod 2016;31:2031–41. https://doi.org/10.1093/humrep/dew165.Suche in Google Scholar PubMed

72. Dolmans, M-M. Safety of ovarian autotransplantation. Blood 2012 Nov 22;120:4275–6. https://doi.org/10.1182/blood-2012-07-439539.Suche in Google Scholar PubMed

73. Fatemi, HM, Kyrou, D, Al-Azemi, M, Stoop, D, De Sutter, P, Bourgain, C, et al. Ex-vivo oocyte retrieval for fertility preservation. Fertil Steril 2011 Apr;95:1787.e15–17. https://doi.org/10.1016/j.fertnstert.2010.11.023.Suche in Google Scholar PubMed

74. Bocca, S, Dedmond, D, Jones, E, Stadtmauer, L, Oehninger, S. Successful extracorporeal mature oocyte harvesting after laparoscopic oophorectomy following controlled ovarian hyperstimulation for the purpose of fertility preservation in a patient with borderline ovarian tumor. J Assist Reprod Genet 2011 Sep;28:771–2. https://doi.org/10.1007/s10815-011-9596-7.Suche in Google Scholar PubMed PubMed Central

75. Telfer, EE. Future developments: In vitro growth (IVG) of human ovarian follicles. Acta Obstet Gynecol Scand 2019 May;98:653–8. https://doi.org/10.1111/aogs.13592.Suche in Google Scholar PubMed

76. Laronda, MM, Rutz, AL, Xiao, S, Whelan, KA, Duncan, FE, Roth, EW, et al. A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice. Nat Commun 2017 16;8:15261. https://doi.org/10.1038/ncomms15261.Suche in Google Scholar PubMed PubMed Central

Received: 2019-11-29
Accepted: 2020-05-02
Published Online: 2020-07-06

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Special Issue 1: Adenomyosis and Endometriosis: An Update; Edited by René Druckmann and Adolf E. Schindler
  3. Review Articles
  4. The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation
  5. A narrative review of functional outcomes following nerve-sparing surgery for deeply infiltrating endometriosis
  6. Appropriate surgical management of ovarian endometrioma: excision or drainage?
  7. Diaphragmatic endometriosis and thoracic endometriosis syndrome: a review on diagnosis and treatment
  8. Rates of anastomotic leak and fistula following surgical management of bowel endometriosis: a comparison of shaving, discoid excision, and segmental resection
  9. Endometriosis at all ages: diagnostic ultrasound
  10. Special Issue 2: Fertility Preservation in Cancer Patients and Survivors; Edited by René Druckmann and Adolf E. Schindler
  11. Opinion Paper
  12. Quality of life and sexual dysfunction in gynaecological cancer patients: a psychosomatic approach
  13. Review Articles
  14. Fertility preservation in women with early ovarian cancer
  15. Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues
  16. Fertility preservation in borderline ovarian tumor patients and survivors
  17. Regular Issue
  18. Original Articles
  19. Effects of iron-related compounds and bilirubin on redox homeostasis in endometriosis and its malignant transformations
  20. miR-515-3p, miR-623, miR-1272 and Notch3 protein as new biomarkers of Hepatocellular carcinoma
  21. Combination therapy of calcitriol inhibits the proliferation of breast cancer cells: new concept of nonclassical function of calcitriol
  22. The change pattern in serum G protein-coupled estrogen receptor-1 (GPER1) levels during pregnancy with and without gestational diabetes mellitus
  23. Effects of Helichrysum Psudoplicatum supplementation on pruritus intensity, fatigue, quality of life and anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial
  24. The anticancer and free radical scavenging potential of the Unani medicine Agaricus albus L.
  25. Review Articles
  26. What is the optimal luteal support in assisted reproductive technology?
  27. The relation between obesity, kisspeptin, leptin, and male fertility
https://doi.org/10.1515/hmbci-2019-0072
Schlagwörter für diesen Artikel
borderline ovarian tumor; fertility preservation; fertility sparing surgery; oocyte cryopreservation; ovarian tissue cryopreservation

Artikel in diesem Heft

  1. Frontmatter
  2. Special Issue 1: Adenomyosis and Endometriosis: An Update; Edited by René Druckmann and Adolf E. Schindler
  3. Review Articles
  4. The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation
  5. A narrative review of functional outcomes following nerve-sparing surgery for deeply infiltrating endometriosis
  6. Appropriate surgical management of ovarian endometrioma: excision or drainage?
  7. Diaphragmatic endometriosis and thoracic endometriosis syndrome: a review on diagnosis and treatment
  8. Rates of anastomotic leak and fistula following surgical management of bowel endometriosis: a comparison of shaving, discoid excision, and segmental resection
  9. Endometriosis at all ages: diagnostic ultrasound
  10. Special Issue 2: Fertility Preservation in Cancer Patients and Survivors; Edited by René Druckmann and Adolf E. Schindler
  11. Opinion Paper
  12. Quality of life and sexual dysfunction in gynaecological cancer patients: a psychosomatic approach
  13. Review Articles
  14. Fertility preservation in women with early ovarian cancer
  15. Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues
  16. Fertility preservation in borderline ovarian tumor patients and survivors
  17. Regular Issue
  18. Original Articles
  19. Effects of iron-related compounds and bilirubin on redox homeostasis in endometriosis and its malignant transformations
  20. miR-515-3p, miR-623, miR-1272 and Notch3 protein as new biomarkers of Hepatocellular carcinoma
  21. Combination therapy of calcitriol inhibits the proliferation of breast cancer cells: new concept of nonclassical function of calcitriol
  22. The change pattern in serum G protein-coupled estrogen receptor-1 (GPER1) levels during pregnancy with and without gestational diabetes mellitus
  23. Effects of Helichrysum Psudoplicatum supplementation on pruritus intensity, fatigue, quality of life and anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial
  24. The anticancer and free radical scavenging potential of the Unani medicine Agaricus albus L.
  25. Review Articles
  26. What is the optimal luteal support in assisted reproductive technology?
  27. The relation between obesity, kisspeptin, leptin, and male fertility
Jetzt anmelden und 20% sparen
Institutioneller Zugang
Wie funktioniert Authentifizierung?
Haben Sie eine Idee, wie wir unsere Website verbessern können?
Bitte schreiben Sie uns.
© 2025 De Gruyter Brill
Heruntergeladen am 22.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/hmbci-2019-0072/html?lang=de
Button zum nach oben scrollen