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The change pattern in serum G protein-coupled estrogen receptor-1 (GPER1) levels during pregnancy with and without gestational diabetes mellitus

  • Berrak Guven EMAIL logo and Yesim Akdemir
Published/Copyright: November 18, 2021
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Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 43 Issue 2

Abstract

Objectives

The purpose of this study was to evaluate serum G protein-coupled estrogen receptor-1 (GPER1) levels in non-pregnant and pregnant with and without gestational diabetes mellitus (GDM).

Methods

The study comprised 40 pregnant women with (n=20) and without GDM (n=20) and 20 healthy non-pregnant women. Data as maternal age, gestational age, and body mass index (BMI) of participants were recorded and serum samples were collected. Serum GPER1 levels were measured by enzyme-linked immunosorbent assays.

Results

Serum GPER1 level was significantly higher in GDM (p=0.03) and non-pregnant women (p=0.005) than those of normal pregnancy. There was no significant correlation between the serum GPER1 levels age (r=0.18, p=0.34), gestational age (r=−0.22, p=0.47), and BMI (r=0.004, p=0.975).

Conclusions

Our results suggest that changes in serum GPER1 levels in pregnancy and GDM may be associated with estrogen. More detailed studies should be conducted to monitor the changes and their interactions in serum sex hormones and serum GPER1 levels during GDM.

Keywords: G protein-coupled estrogen receptor-1 (GPER1); gestational diabetes mellitus (GDM); pregnancy
Corresponding author: Berrak Guven, Department of Biochemistry, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey, Phone: +90 0372 2612839, Fax: +90 0372 2610155, E-mail:

  1. Research funding: Authors declare that they did not receive any financial support in this study.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: All authors declare no conflicts of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: Present study was conducted in line with the ethical standards specified by the Declaration of Helsinki and local ethical committee approval.

References

1. Barros, RP, Gustafsson, JA. Estrogen receptors and the metabolic network. Cell Metabol 2011;14:289–99. https://doi.org/10.1016/j.cmet.2011.08.005.Search in Google Scholar

2. Filardo, E, Quinn, J, Pang, Y, Graeber, C, Shaw, S, Dong, J, et al.. Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology 2007;148:3236–45. https://doi.org/10.1210/en.2006-1605.Search in Google Scholar

3. Prossnitz, ER, Barton, M. The G protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol 2011;7:715–26. https://doi.org/10.1038/nrendo.2011.122.Search in Google Scholar

4. Haas, E, Bhattacharya, I, Brailoiu, E, Damjanovic, M, Brailoiu, GC, Gao, X, et al.. Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res 2009;104:288–91. https://doi.org/10.1161/circresaha.108.190892.Search in Google Scholar

5. Sharma, G, Hu, C, Brigman, JL, Zhu, G, Hathaway, HJ, Prossnitz, ER. GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology 2013;154:4136–45. https://doi.org/10.1210/en.2013-1357.Search in Google Scholar

6. Sharma, G, Prossnitz, ER. Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells. Endocrinology 2011;152:3030–9. https://doi.org/10.1210/en.2011-0091.Search in Google Scholar

7. Gilmartin, AG, Ural, SH, Repke, JT. Gestational diabetes mellitus. Rev Obstet Gynecol 2008;1:129–34.Search in Google Scholar

8. Barbour, LA, McCurdy, CE, Hernandez, TL, Kirwan, JP, Catalano, PM, Friedman, JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care 2007;30:112–9. https://doi.org/10.2337/dc07-s202.Search in Google Scholar

9. Catalano, PM, Tyzbir, ED, Roman, NM. Longitudinal changes in insulin release and insulin resistance in non-obese pregnant women. Am J Obstet Gynecol 1991;165:1667–72. https://doi.org/10.1016/0002-9378(91)90012-g.Search in Google Scholar

10. Napso, T, Yong, HEJ, Lopez-Tello, J, Sferruzzi-Perri, AN. The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation. Front Physiol 2018;17:1091. https://doi.org/10.3389/fphys.2018.01091.Search in Google Scholar PubMed PubMed Central

11. Metzger, BE, Gabbe, SG, Persson, B, Buchanan, TA, Catalano, PA, Damm, P, et al.. International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010;33:676–82. https://doi.org/10.2337/dc09-1848.Search in Google Scholar PubMed PubMed Central

12. Sharma, G, Prossnitz, ER. G Protein-Coupled estrogen receptor (GPER) and sex-specific metabolic homeostasis. Adv Exp Med Biol 2017;1043:427–53. https://doi.org/10.1007/978-3-319-70178-3_20.Search in Google Scholar PubMed PubMed Central

13. Trenti, A, Tedesco, S, Boscaro, C, Trevisi, L, Bolego, C, Cignarella, A. Estrogen, angiogenesis, immunity and cell metabolism: solving the puzzle. Int J Mol Sci 2018;19:859. https://doi.org/10.3390/ijms19030859.Search in Google Scholar PubMed PubMed Central

14. Groban, L, Tran, QK, Ferrario, MC, Sun, X, Ping, CC, Kitzman, DW, et al.. Female heart health: is GPER the missing link? Front Endocrinol 2019;10:919. https://doi.org/10.3389/fendo.2019.00919.Search in Google Scholar PubMed PubMed Central

15. Wang, C, Prossnitz, ER, Roy, SK. G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary. Endocrinology 2008;149:4452–61. https://doi.org/10.1210/en.2008-0441.Search in Google Scholar PubMed PubMed Central

16. Marjon, NA, Hu, C, Hathaway, HJ, Prossnitz, ER. G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis. Mol Cancer Res 2014;12:1644–54. https://doi.org/10.1158/1541-7786.mcr-14-0128-t.Search in Google Scholar PubMed PubMed Central

17. Ford, SP. Control of uterine and ovarian blood flow throughout the estrous cycle and pregnancy of ewes, sows and cows. J Anim Sci 1982;55(2 Suppl):32–42. https://doi.org/10.2527/1982.55Supplement_II32x.Search in Google Scholar

18. Soldin, OP, Guo, T, Weiderpass, E, Tractenberg, RE, Hilakivi-Clarke, L, Soldin, SJ. Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry. Fertil Steril 2005;84:701–10. https://doi.org/10.1016/j.fertnstert.2005.02.045.Search in Google Scholar PubMed PubMed Central

19. Magness, RR, Phernetton, TM, Gibson, TC, Chen, DB. Uterine blood flow responses to ICI 182 780 in ovariectomized oestradiol-17beta-treated, intact follicular and pregnant sheep. J Physiol 2005;565:71–83. https://doi.org/10.1113/jphysiol.2005.086439.Search in Google Scholar PubMed PubMed Central

20. Gibson, TC, Phernetton, TM, Wiltbank, MC, Magness, RR. Development and use of an ovarian synchronization model to study the effects of endogenous estrogen and nitric oxide on uterine blood flow during ovarian cycles in sheep. Biol Reprod 2004;70:1886–94. https://doi.org/10.1095/biolreprod.103.019901.Search in Google Scholar PubMed

21. Byers, MJ, Zangl, A, Phernetton, TM, Lopez, G, Chen, DB, Magness, RR. Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels. J Physiol 2005;565:85–99. https://doi.org/10.1113/jphysiol.2005.085753.Search in Google Scholar PubMed PubMed Central

22. Kolkova, Z, Noskova, V, Ehinger, A, Hansson, S, Casslén, B. G protein-coupled estrogen receptor 1 (GPER, GPR 30) in normal human endometrium and early pregnancy decidua. Mol Hum Reprod 2010;16:743–51. https://doi.org/10.1093/molehr/gaq043.Search in Google Scholar PubMed

23. Feng, X, Zhou, L, Mao, X, Tong, C, Chen, X, Zhao, D, et al.. Association of a reduction of G-protein coupled receptor 30 expression and the pathogenesis of preeclampsia. Mol Med Rep 2017;16:5997–6003. https://doi.org/10.3892/mmr.2017.7341.Search in Google Scholar PubMed PubMed Central

24. Ozer, A, Tolun, F, Aslan, F, Hatırnaz, S, Alkan, F. The role of G protein-associated estrogen receptor (GPER) 1, corin, raftlin, and estrogen in etiopathogenesis of intrauterine growth retardation. J Matern Fetal Neonatal Med 2021;34:755–60. https://doi.org/10.1080/14767058.2019.1615433.Search in Google Scholar PubMed

25. Xiuyu, Q, Bo, G, Jing, Y, Limin, S, Wanling, J, Zhenmin, W, et al.. Decreased cord blood estradiol levels in related to mothers with gestational diabetes. Medicine (Baltim) 2017;96:e6962.10.1097/MD.0000000000006962Search in Google Scholar PubMed PubMed Central

Received: 2021-03-10
Accepted: 2021-11-03
Published Online: 2021-11-18

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/hmbci-2021-0023
Keywords for this article
G protein-coupled estrogen receptor-1 (GPER1); gestational diabetes mellitus (GDM); pregnancy

Articles in the same Issue

  1. Frontmatter
  2. Special Issue 1: Adenomyosis and Endometriosis: An Update; Edited by René Druckmann and Adolf E. Schindler
  3. Review Articles
  4. The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation
  5. A narrative review of functional outcomes following nerve-sparing surgery for deeply infiltrating endometriosis
  6. Appropriate surgical management of ovarian endometrioma: excision or drainage?
  7. Diaphragmatic endometriosis and thoracic endometriosis syndrome: a review on diagnosis and treatment
  8. Rates of anastomotic leak and fistula following surgical management of bowel endometriosis: a comparison of shaving, discoid excision, and segmental resection
  9. Endometriosis at all ages: diagnostic ultrasound
  10. Special Issue 2: Fertility Preservation in Cancer Patients and Survivors; Edited by René Druckmann and Adolf E. Schindler
  11. Opinion Paper
  12. Quality of life and sexual dysfunction in gynaecological cancer patients: a psychosomatic approach
  13. Review Articles
  14. Fertility preservation in women with early ovarian cancer
  15. Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues
  16. Fertility preservation in borderline ovarian tumor patients and survivors
  17. Regular Issue
  18. Original Articles
  19. Effects of iron-related compounds and bilirubin on redox homeostasis in endometriosis and its malignant transformations
  20. miR-515-3p, miR-623, miR-1272 and Notch3 protein as new biomarkers of Hepatocellular carcinoma
  21. Combination therapy of calcitriol inhibits the proliferation of breast cancer cells: new concept of nonclassical function of calcitriol
  22. The change pattern in serum G protein-coupled estrogen receptor-1 (GPER1) levels during pregnancy with and without gestational diabetes mellitus
  23. Effects of Helichrysum Psudoplicatum supplementation on pruritus intensity, fatigue, quality of life and anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial
  24. The anticancer and free radical scavenging potential of the Unani medicine Agaricus albus L.
  25. Review Articles
  26. What is the optimal luteal support in assisted reproductive technology?
  27. The relation between obesity, kisspeptin, leptin, and male fertility
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