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The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation

  • Daniel Necula EMAIL logo , Andrea Gmuer und Jérôme Mathis
Veröffentlicht/Copyright: 10. März 2021
Hormone Molecular Biology and Clinical Investigation
Aus der Zeitschrift Hormone Molecular Biology and Clinical Investigation Band 43 Heft 2

Abstract

Endometriosis is one of the most common diseases associated with infertility. It requires different therapeutic approaches, depending on the type, whether superficial, ovarian or deep endometriotic nodules, clinical presentation, age or origin of infertility. Patients with endometriosis should be considered a group of high-risk for infertility and any intervention should be planned taking this consideration into account. For many years, surgery was the only tool in improving fertility outcomes. Nowadays, it remains the gold standard for the treatment of endometriosis, but it should be carefully used because of its harmful potential, leading to premature ovarian insufficiency and further infertility. With the development of modern assisted reproductive techniques (ART), which can offer better results in terms of fertility, the role of surgery progressively decreased. Nowadays, therapeutic approach is complex and multidisciplinary teams should be guiding individual treatment for each woman. Options include medical treatment, surgery, in vitro fertilization (IVF) or oocytes/embryo/ovarian tissue cryopreservation. There is a constant effort in developing diagnostic scores, in order to predict risk of infertility and create standard of practice, offering a long-term approach in terms of fertility preservation and quality of life.

Keywords: assisted reproductive techniques; endometrioma; endometriosis; fertility preservation; in vitro fertilization; surgery
Corresponding author: Daniel Necula, Gynecology and Obstetrics Unit, Biel/Bienne Hospital, Biel, Switzerland, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors declare no conflicts of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

References

1. Barnett, R, Banks, N, Decherney, AH. Endometriosis and fertility preservation. Clin Obstet Gynecol 2017;60:517–23.10.1097/GRF.0000000000000311Suche in Google Scholar

2. Nickkho-Amiry, M, Savant, R, Majumer, K, Edi-O’sagie, E, Akhtar, M. The effect of surgical management of endometrioma on the IVF/ICSI outcomes when compared with no treatment? A systematic review and meta-analysis. Arch Gynecol Obstet 2018;4:1043–57.10.1007/s00404-017-4640-1Suche in Google Scholar

3. Kitajima, M, Dolmans, M-M, Donnez, O, Masuzaki, H, Soares, M, Donnez, J. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril 2014;4:1031–7.10.1016/j.fertnstert.2013.12.049Suche in Google Scholar

4. Muzii, L, Di Tucci, C, Di Feliciantonio, M, Galati, G, Di Donato, V, Musella, A, et al.. Antimullerian hormone is reduced in the presence of ovarian endometriomas: a systematic review and meta-analysis. Fertil Steril 2018;5:932–40.10.1016/j.fertnstert.2018.06.025Suche in Google Scholar

5. Kasapoglu, I, Ata, B, Uyaniklar, O, Seyhan, A, Orhan, A, Oguz, SY, et al.. Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study. Fertil Steril 2018;1:122–7.10.1016/j.fertnstert.2018.03.015Suche in Google Scholar

6. Yasuia, T, Hayashib, K, Mizunumac, H, Kubotad, T, Asod, T, Matsumurae, Y, et al.. Association of endometriosis-related infertility with age at menopause. Maturitas 2011;3:279–83.10.1016/j.maturitas.2011.04.009Suche in Google Scholar

7. Simon, C, Gutierrez, A, Vidal, A, de los Santos, MJ, Tarin, JJ, Remohi, J, et al.. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 1994;4:725–9.10.1093/oxfordjournals.humrep.a138578Suche in Google Scholar

8. Giudice, C, Kao, L. Endometriosis. Lancet 2004;364:1798–9.10.1016/S0140-6736(04)17403-5Suche in Google Scholar

9. Ridley, JH. Coelomic metaplasia. Am J Obstet Gynecol 1981;2:233–4.10.1016/0002-9378(81)90113-7Suche in Google Scholar

10. Foti, PV, Farina, R, Palmucci, S, Vizzini, IAA, Libertini, N, Coronella, M, et al.. Endometriosis: clinical features, MR imaging findings and pathologic correlation. Insights Imag 2018;2:149–72.10.1007/s13244-017-0591-0Suche in Google Scholar PubMed PubMed Central

11. Jomova, K, Valko, M. Importance of iron chelation in free radical-induced oxidative stress and human disease. Curr Pharmaceut Des 2011;31:3460–73.10.2174/138161211798072463Suche in Google Scholar PubMed

12. Opoien, HK, Fedorcsak, P, Polec, A, Stensen, MH, Abyholm, T, Tanbo, T. Do endometriomas induce an inflammatory reaction in nearby follicles? Hum Reprod 2013;7:1837–45.10.1093/humrep/det087Suche in Google Scholar PubMed

13. Vercellini, P, Consonni, D, Dridi, D, Bracco, B, Frattaruolo, MP, Somigliana, E. Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis. Hum Reprod 2014;5:964–77.10.1093/humrep/deu041Suche in Google Scholar PubMed

14. Martinez-Conejero, JA, Morgan, M, Montesinos, M, Fortuno, S, Meseguer, M, Simon, C, et al.. Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation. Fertil Steril 2011;4:943–50.10.1016/j.fertnstert.2011.07.1088Suche in Google Scholar PubMed

15. Raffi, F, Metwally, M, Amer, S. The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis. J Clin Endocrinol Metab 2012;9:3146–54.10.1210/jc.2012-1558Suche in Google Scholar PubMed

16. Chang, HJ, Han, SH, Lee, JR, Jee, BC, Lee, BI, Suh, CS, et al.. Impact of laparoscopic cystectomy on ovarian reserve: serial changes of serum anti-Mullerian hormone levels. Fertil Steril 2010;94:343–9. https://doi.org/10.1016/j.fertnstert.2009.02.022.Suche in Google Scholar PubMed

17. Muzii, L, Di Tucci, C, Di Feliciantonio, M, Galati, G, Pecorella, I, Radicioni, A, et al.. Ovarian reserve reduction with surgery is not correlated with the amount of ovarian tissue inadvertently excised at laparoscopic surgery for endometriomas. Reprod Sci 2019;11:1493–8.10.1177/1933719119828055Suche in Google Scholar PubMed

18. American Society for Reproductive Medicine. Revised American Society for reproductive medicine. Fertil Steril 1997;5:817–21.10.1016/S0015-0282(97)81391-XSuche in Google Scholar

19. Vercellini, P, Somigliana, E, Vigano, P, Abbiati, A, Barbara, G, Crosignani, PG. Surgery for endometriosis-associated infertility: a pragmatic approach. Hum Reprod 2009;2:54–69.10.1093/humrep/den379Suche in Google Scholar PubMed

20. Marcoux, S, Maheux, R, Bérubé, S, Canadian Collaborative Group on Endometriosis. Laparoscopic surgery in infertile women with minimal or mild endometriosis. N Engl J Med 1997;4:217–22.10.1056/NEJM199707243370401Suche in Google Scholar PubMed

21. Bendifallah, S, Roman, H, d’Argent, EM, Touleimat, S, Cohen, J, Darai, E, et al.. Colorectal endometriosis-associated infertility: should surgery precede ART? Fertil Steril 2017;3:525–31.10.1016/j.fertnstert.2017.07.002Suche in Google Scholar PubMed

22. Ferrero, S, Scala, C, Tafi, E, Racca, A, Venturini, PL, Maggiore, ULR. Impact of large ovarian endometriomas on the response to superovulation for in vitro fertilization: a retrospective study. Eur J Obstet Gynecol Reprod Biol 2017;213:17–21.10.1016/j.ejogrb.2017.04.003Suche in Google Scholar PubMed

23. Almog, B, Shehata, F, Sheizaf, B, Tan, SL, Tulandi, T. Effects of ovarian endometrioma on the number of oocytes retrieved for in vitro fertilization. Fertil Steril 2011;2:252–7.10.1016/j.fertnstert.2010.03.011Suche in Google Scholar PubMed

24. Somigliana, E, Arnoldi, M, Benaglia, L, Iemmello, R, Nicolosi, AE, Ragni, G. IVF–ICSI outcome in women operated on for bilateral endometriomas. Hum Reprod 2008;7:1526–30.10.1093/humrep/den133Suche in Google Scholar PubMed

25. Kitajima, M, Khan, KN, Harada, A, Taniguchi, K, Inoue, T, Kaneuchi, M, et al.. Association between ovarian endometrioma and ovarian reserve. Front Biosci 2018;10:92–102.10.2741/e810Suche in Google Scholar PubMed

26. Younis, JS, Shapso, N, Fleming, R, Ben-Shlomo, I, Izhaki, I. Impact of unilateral versus bilateral ovarian endometriotic cystectomy on ovarian reserve: a systematic review and meta-analysis. Hum Reprod Update 2019;3:375–91.10.1093/humupd/dmy049Suche in Google Scholar PubMed

27. Ding, W, Li, M, Teng, Y. The impact on ovarian reserve of haemostasis by bipolar coagulation versus suture following surgical stripping of ovarian endometrioma: a meta-analysis. Reprod BioMed Online 2015;6:635–42.10.1016/j.rbmo.2015.02.012Suche in Google Scholar PubMed

28. Ata, B, Turkgeldi, E, Seyhan, A, Urman, B. Effect of hemostatic method on ovarian reserve following laparoscopic endometrioma excision; comparison of suture, hemostatic sealant, and bipolar dessication. A systematic review and meta-analysis. J Minim Invasive Gynecol 2015;3:363–72.10.1016/j.jmig.2014.12.168Suche in Google Scholar PubMed

29. Muzii, L, Di Tucci, C, Di Feliciantonio, M, Marchetti, C, Perniola, G, Panici, PB. The effect of surgery for endometrioma on ovarian reserve evaluated by antral follicle count: a systematic review and meta-analysis. Hum Reprod 2014;10:2190–8.10.1093/humrep/deu199Suche in Google Scholar PubMed

30. Somigliana, E, Berlanda, N, Benaglia, L, Viganò, P, Vercellini, P, Fedele, L. Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antimüllerian hormone level modi cations. Fertil Steril 2012;6:1531–8.10.1016/j.fertnstert.2012.08.009Suche in Google Scholar PubMed

31. Maheux-Lacroix, S, Nesbitt-Hawes, E, Deans, R, Won, H, Budden, A, Adamson, D, et al.. Endometriosis fertility index predicts live births following surgical resection of moderate and severe endometriosis. Hum Reprod 2017;32:2243–9.https://doi.org/10.1093/humrep/dex291.Suche in Google Scholar PubMed

32. Adamson, GD, Pasta, DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril 2010;5:1609–15.10.1016/j.fertnstert.2009.09.035Suche in Google Scholar PubMed

33. Harb, HM, Gallos, ID, Chu, J, Harb, M, Coomarasamy, A. The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis. Br J Obstet Gynecol 2013;11:1308–20.10.1111/1471-0528.12366Suche in Google Scholar PubMed

34. Opøien, HK, Fedorcsak, P, Omland, AK, Abyholm, T, Bjercke, S, Ertzeid, N, et al.. In vitro fertilization is a successful treatment in endometriosis-associated infertility. Fertil Steril 2012;4:912–8.10.1016/j.fertnstert.2012.01.112Suche in Google Scholar PubMed

35. Yang, C, Geng, Y, Li, Y, Chen, C, Gao, Y. Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis. Reprod Biomed Online 2015;1:9–19.10.1016/j.rbmo.2015.03.005Suche in Google Scholar PubMed

36. Hamdan, M, Dunselman, G, Li, TC, Cheong, Y. The impact of endometrioma on IVF/ICSI outcomes: a systematic review and meta-analysis. Hum Reprod Update 2015;6:809–25.10.1093/humupd/dmv035Suche in Google Scholar PubMed

37. Brink Laursen, J, Schroll, JB, Macklon, KT, Rudnicki, M. Surgery versus conservative management of endometriomas in subfertile women. A systematic review. Acta Obstet Gynecol Scand 2017;6:727–35.10.1111/aogs.13154Suche in Google Scholar PubMed

38. Wu, CQ, Albert, A, Alfaraj, S, Taskin, O, Alkusayer, G, Havelock, J, et al.. Live birth rate after surgical and expectant management of endometriomas after in vitro fertilization: a systematic review, meta-analysis, and critical appraisal of current guidelines and previous meta-analyses. J Minim Invasive Gynecol 2019;2:299–311.10.1016/j.jmig.2018.08.029Suche in Google Scholar PubMed

39. Tsoumpou, I, Kyrgiou, M, Gelbaya, TA, Nardo, LG. The effect of surgical treatment for endometrioma on in vitro fertilization outcomes: a systematic review and meta-analysis. Fertil Steril 2009;1:75–87.10.1016/j.fertnstert.2008.05.049Suche in Google Scholar PubMed

40. Georgiou, EX, Melo, P, Baker, PE, Sallam, H, Arici, A, Garcia-Velasco, A, et al.. Long-term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis. Cochrane Database Syst Rev 2019;2019:CD013240. https://doi.org/10.1002/14651858.cd013240.pub2.Suche in Google Scholar PubMed PubMed Central

41. Somigliana, E, Vigano, P, Filippi, F, Papaleo, E, Benaglia, L, Candiani, M, et al.. Fertility preservation in women with endometriosis: for all, for some, for none? Hum Reprod 2015;6:1280–6.10.1093/humrep/dev078Suche in Google Scholar PubMed

42. Loren, AW, Mangu, PB, Beck, LN, Brennan, L, Partridge, A, Quinn, G, et al.. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 2013;19:2500–10.10.1200/JCO.2013.49.2678Suche in Google Scholar PubMed PubMed Central

43. Lantsberg, D, Fernando, S, Cohen, Y, Rombauts, L. The role of fertility preservation in women with endometriosis: a systematic review. J Minim Invasive Gynecol 2020;2:362–72.10.1016/j.jmig.2019.09.780Suche in Google Scholar PubMed

44. Cobo, A, Giles, J, Paolelli, S, Pellicer, A, Remohí, J, García-Velasco, JA. Oocyte vitrification for fertility preservation in women with endometriosis: an observational study. Fertil Steril 2020;4:836–44.10.1016/j.fertnstert.2019.11.017Suche in Google Scholar PubMed

45. Entwistle, V, Firnigl, D, Ryan, M, Francis, J, Kinghorn, P. Which experiences of health care delivery matter to service users and why? A critical interpretive synthesis and conceptual map. J Health Serv Res Pol 2012;2:70–8.10.1258/jhsrp.2011.011029Suche in Google Scholar PubMed PubMed Central

Received: 2020-11-22
Accepted: 2021-02-18
Published Online: 2021-03-10

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Special Issue 1: Adenomyosis and Endometriosis: An Update; Edited by René Druckmann and Adolf E. Schindler
  3. Review Articles
  4. The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation
  5. A narrative review of functional outcomes following nerve-sparing surgery for deeply infiltrating endometriosis
  6. Appropriate surgical management of ovarian endometrioma: excision or drainage?
  7. Diaphragmatic endometriosis and thoracic endometriosis syndrome: a review on diagnosis and treatment
  8. Rates of anastomotic leak and fistula following surgical management of bowel endometriosis: a comparison of shaving, discoid excision, and segmental resection
  9. Endometriosis at all ages: diagnostic ultrasound
  10. Special Issue 2: Fertility Preservation in Cancer Patients and Survivors; Edited by René Druckmann and Adolf E. Schindler
  11. Opinion Paper
  12. Quality of life and sexual dysfunction in gynaecological cancer patients: a psychosomatic approach
  13. Review Articles
  14. Fertility preservation in women with early ovarian cancer
  15. Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues
  16. Fertility preservation in borderline ovarian tumor patients and survivors
  17. Regular Issue
  18. Original Articles
  19. Effects of iron-related compounds and bilirubin on redox homeostasis in endometriosis and its malignant transformations
  20. miR-515-3p, miR-623, miR-1272 and Notch3 protein as new biomarkers of Hepatocellular carcinoma
  21. Combination therapy of calcitriol inhibits the proliferation of breast cancer cells: new concept of nonclassical function of calcitriol
  22. The change pattern in serum G protein-coupled estrogen receptor-1 (GPER1) levels during pregnancy with and without gestational diabetes mellitus
  23. Effects of Helichrysum Psudoplicatum supplementation on pruritus intensity, fatigue, quality of life and anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial
  24. The anticancer and free radical scavenging potential of the Unani medicine Agaricus albus L.
  25. Review Articles
  26. What is the optimal luteal support in assisted reproductive technology?
  27. The relation between obesity, kisspeptin, leptin, and male fertility
https://doi.org/10.1515/hmbci-2020-0082
Schlagwörter für diesen Artikel
assisted reproductive techniques; endometrioma; endometriosis; fertility preservation; in vitro fertilization; surgery

Artikel in diesem Heft

  1. Frontmatter
  2. Special Issue 1: Adenomyosis and Endometriosis: An Update; Edited by René Druckmann and Adolf E. Schindler
  3. Review Articles
  4. The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation
  5. A narrative review of functional outcomes following nerve-sparing surgery for deeply infiltrating endometriosis
  6. Appropriate surgical management of ovarian endometrioma: excision or drainage?
  7. Diaphragmatic endometriosis and thoracic endometriosis syndrome: a review on diagnosis and treatment
  8. Rates of anastomotic leak and fistula following surgical management of bowel endometriosis: a comparison of shaving, discoid excision, and segmental resection
  9. Endometriosis at all ages: diagnostic ultrasound
  10. Special Issue 2: Fertility Preservation in Cancer Patients and Survivors; Edited by René Druckmann and Adolf E. Schindler
  11. Opinion Paper
  12. Quality of life and sexual dysfunction in gynaecological cancer patients: a psychosomatic approach
  13. Review Articles
  14. Fertility preservation in women with early ovarian cancer
  15. Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues
  16. Fertility preservation in borderline ovarian tumor patients and survivors
  17. Regular Issue
  18. Original Articles
  19. Effects of iron-related compounds and bilirubin on redox homeostasis in endometriosis and its malignant transformations
  20. miR-515-3p, miR-623, miR-1272 and Notch3 protein as new biomarkers of Hepatocellular carcinoma
  21. Combination therapy of calcitriol inhibits the proliferation of breast cancer cells: new concept of nonclassical function of calcitriol
  22. The change pattern in serum G protein-coupled estrogen receptor-1 (GPER1) levels during pregnancy with and without gestational diabetes mellitus
  23. Effects of Helichrysum Psudoplicatum supplementation on pruritus intensity, fatigue, quality of life and anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial
  24. The anticancer and free radical scavenging potential of the Unani medicine Agaricus albus L.
  25. Review Articles
  26. What is the optimal luteal support in assisted reproductive technology?
  27. The relation between obesity, kisspeptin, leptin, and male fertility
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