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Correlates of zinc finger BED domain-containing protein 3 and ghrelin in metabolic syndrome patients with and without prediabetes

  • Rawan AbuZayed , Nailya Bulatova , Violet Kasabri ORCID logo EMAIL logo , Maysa Suyagh , Lana Halaseh and Sundus AlAlawi
Published/Copyright: January 22, 2019
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Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 37 Issue 3

Abstract

Background

Ghrelin and zinc finger BED domain-containing protein 3 (ZBED3) are distinctively cross linked with prediabetes (preDM) and metabolic syndrome (MetS).

Materials and methods

In a cross-sectional design with 29 normoglycemic MetS and 30 newly diagnosed drug naïve preDM/MetS patients vs. 29 lean and normoglycemic controls; ghrelin and ZBED3 were evaluated using colorimetric enzymatic assays.

Results

While ZBED3 mean circulating levels (ng/mL) in both MetS groups (normoglycemic and preDM) invariably lacked discrepancy vs. controls; Appreciably ghrelin levels (ng/mL) in preDM/MetS (but not normoglycemic MetS) participants were markedly higher vs. controls. Except for fasting plasma glucose (FPG) and glycosylated-hemoglobin (HbA1C); no further intergroup discrepancy could be identified between the MetS arms. Remarkably adiposity indices (body mass index (BMI), body adiposity index (BAI), and lipid accumulation product (LAP), but not conicity index (CI) or visceral adiposity index (VAI)); atherogenicity index of plasma (but not non-high-density lipoprotein-cholesterol (non-HDL-C/HDL-C) ratio, or total cholesterol (TC)/HDL-C ratio) or any of hematological indices (red cell distribution width (RDW-CV%), monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR) and platelet (PLT) to lymphocyte ratio (PLR)) were substantially higher in both MetS (non- and preDM) groups vs. those of controls. Exceptionally low-density lipoprotein -cholesterol (LDL-C)/HDL-C ratio, and waist circumference (WC)/hip circumference (HC) ratio were much more pronounced in MetS-preDM vs. normoglycemic MetS recruits. In the MetS pool (both normoglycemic and preDM, n = 58), neither biomarker could relate to each other, or any of clinical parameters, adiposity or atherogenecity indices. Exceptionally ghrelin correlated significantly and inversely with age. ZBED3 correlated significantly and directly with RDW-CV% in the same pool of MetS recruits (n = 59).

Conclusions

Both biomarkers can not be ruled out as putative predictive/surrogate prognostic tools for metabolic anomalies prevention and pharmacotherapy.

Keywords: adiposity; atherogenicity and hematological indices; ghrelin; metabolic syndrome; prediabetes; zinc finger BED domain-containing protein 3

Acknowledgment

Authors are thankful for The Deanship of Academic Research and Quality Assurance/The University of Jordan for supporting this research.

Author Statement

  1. Research funding: Authors state no funding was involved.

  2. Conflict of interest: The authors declare none.

  3. Informed consent: Informed consent has been obtained from the participants.

  4. Ethical approval: The study was approved by the (IRB) committee of the University of Jordan Hospital and from the Scientific Research Committee at the School of Pharmacy.

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Supplementary Material

The online version of this article offers supplementary material (DOI: https://doi.org/10.1515/hmbci-2018-0052).

Received: 2018-07-15
Accepted: 2018-12-02
Published Online: 2019-01-22

©2019 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/hmbci-2018-0052
Keywords for this article
adiposity; atherogenicity and hematological indices; ghrelin; metabolic syndrome; prediabetes; zinc finger BED domain-containing protein 3

Articles in the same Issue

  1. Original Articles
  2. The effects of estradiol and testosterone on renal tissues oxidative after central injection of angiotensin II in female doca – salt treated rats
  3. Correlates of resistin and retinol-binding protein 4 in metabolic syndrome patients with and without prediabetes
  4. Correlates of zinc finger BED domain-containing protein 3 and ghrelin in metabolic syndrome patients with and without prediabetes
  5. Copper and zinc in stage I multiple myeloma: relation with ceruloplasmin, lipid peroxidation, and superoxide dismutase activity
  6. Short Communication
  7. Ovarian reserve in adolescent girls born prematurely
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