Copper and zinc in stage I multiple myeloma: relation with ceruloplasmin, lipid peroxidation, and superoxide dismutase activity
-
Mohammad-Hassan Khadem-Ansari
, Mojtaba Asoudeh , Hosein Fallahi Kord Gheshlaghi , Samira Nozari , Mina Zarringol , Nazila Fathi Maroufi and Yousef Faridvand
Abstract
Background
The main aim of this study was to assess the serum levels of copper (Cu), zinc (Zn) with lipid peroxidation, Cu/Zn superoxide dismutase (Cu/Zn SOD) activity, and ceruloplasmin (Cp) in multiple myeloma (MM) patients.
Materials and methods
The study was conducted in 34 MM patients at stage I. Serum Cu and Zn levels were measured by atomic absorption spectrometry. Also, spectrophotometric assays of malondialdehyde (MDA) levels in addition to Cp and Cu/Zn SOD were quantitated.
Results
The results showed a significant decrease in the serum Zn levels in patients with MM (p < 0.0001). Also, serum Cu levels were significantly higher (p < 0.0001). However, the serum Cu/Zn ratio was significantly higher in the cancer patients (p < 0.0001). A significant difference was observed in the patients group compared with the control group according to the Cu/Zn SOD activity (p < 0.0001). Moreover, serum levels of Cp and MDA were significantly increased in patients (p < 0.0001, both).
Conclusions
The elevated levels of serum Cu and MDA with a decrease in Zn and Cu/Zn SOD might explain the increased oxidative stress in MM disease. As the high Cu level was observed in MM patients, therefore, Cu levels should be concentrated in the pathogenesis and progression of MM disease.
Acknowledgments
We thank the Urmia University of Medical Sciences (Department of Medicine) for kindly providing and supporting of this project. We also wish to thank Mr. Masoud Isa Khajelou the English editor of “Depiction of Health” journal for his English editing assistance.
Author Statement
Research funding: The authors state no funding involved.
Conflict of interest: The authors have no conflicts of interest in regard to this research.
Informed consent: It was taken.
Ethical approval: The study protocol was approved by the Local Ethical Committee.
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- Correlates of resistin and retinol-binding protein 4 in metabolic syndrome patients with and without prediabetes
- Correlates of zinc finger BED domain-containing protein 3 and ghrelin in metabolic syndrome patients with and without prediabetes
- Copper and zinc in stage I multiple myeloma: relation with ceruloplasmin, lipid peroxidation, and superoxide dismutase activity
- Short Communication
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Articles in the same Issue
- Original Articles
- The effects of estradiol and testosterone on renal tissues oxidative after central injection of angiotensin II in female doca – salt treated rats
- Correlates of resistin and retinol-binding protein 4 in metabolic syndrome patients with and without prediabetes
- Correlates of zinc finger BED domain-containing protein 3 and ghrelin in metabolic syndrome patients with and without prediabetes
- Copper and zinc in stage I multiple myeloma: relation with ceruloplasmin, lipid peroxidation, and superoxide dismutase activity
- Short Communication
- Ovarian reserve in adolescent girls born prematurely