Startseite Dehydroepiandrosterone and/or its metabolites: possible androgen receptor antagonistic effects on digitized mammographic breast density in normal breast tissue of postmenopausal women
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Dehydroepiandrosterone and/or its metabolites: possible androgen receptor antagonistic effects on digitized mammographic breast density in normal breast tissue of postmenopausal women

  • Eva Lundström , Kjell Carlström , Sabine Naessen und Gunnar Söderqvist EMAIL logo
Veröffentlicht/Copyright: 25. August 2018
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Abstract

Background

Androgens, notably testosterone inhibit breast cell proliferation and negative correlations between free testosterone (fT) and breast cell proliferation as well as mammographic density have been described. Dehydroepiandrosterone (DHEA) is reported to be a partial androgen antagonist in breast tumor cells in vitro. Our aim was to investigate if circulating DHEA had any effects on the association between circulating fT and mammographic density in vivo in the normal postmenopausal breast.

Methods

We measured visual and digitized mammographic density and serum DHEA, testosterone, sex-hormone-binding globulin and calculated fT in 84 healthy untreated postmenopausal women.

Results

Significant negative correlations between fT and both visual and digitized mammographic density were strengthened when the median DHEA level decreased from 10.2 to 8.6 nmol/L. Thereafter, correlations became weaker again probably due to decreasing fT levels and/or sample size. There were no correlations between mammographic density and DHEA, at any of the DHEA concentration ranges studied. Serum levels of fT and DHEA were positively correlated.

Conclusion

Our findings demonstrate that circulating DHEA and/or its metabolites counteract the inhibitory action of fT on mammographic breast density.

Acknowledgments

Skilful technical assistance was provided by Catharina Karlsson, Birgitta Byström and Berit Legerstam.

Author Statement

  1. Research funding: This study was supported by grants from the Swedish Cancer Society, the Swedish Research Council (project No. 5982), the Karolinska Institutet Research Funds and NV ORGANON, Oss, The Netherlands.

  2. Conflict of interest: All authors declare no conflict of interest.

  3. Informed consent: Informed consent has been obtained from all individuals included into the study.

  4. Ethical approval: The research results related to human use complied with all the relevant national regulations and institutional policies, was performed in accordance to the tenets of the Helsinki Declaration and has been approved by the local institutional review board.

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Received: 2018-05-29
Accepted: 2018-07-02
Published Online: 2018-08-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

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